US5709654A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus for cooling living tissue
Assignee: Organ Recovery Systems Inc
•
Filing: 1995-06-07
•
Granted: 1998-01-20
•
Expires: 2015-06-07
Abstract
Abstract The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines.
Inventors
- 👤 Ronald M. Klatz
- 👤 Robert M. Goldman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:22
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A01N1/14; A01N1/142; A01N1/143; A61; A61B; A61B16/00; A61H; A61H31/00; A61M; A61M16/00; A61M16/0054; A61M16/021; A61M16/022; A61M5/00; A61M5/14; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/20; A61M60/247; A61M60/253; A61M60/268; A61M60/30; A61M60/31; A61M60/36; A61M60/38; A61M60/40; A61M60/424; A61M60/427; A61M60/50; A61M60/508; A61M60/538; A61M60/546; A61B17/00; A61B2017/00969; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2210/00; A61M2210/06; A61M2210/0693; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
100 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing an intravenously biocompatible solution within said at least one reservoir and said at least one reservoir having a solution outlet and an oxygen inlet separate from said solution outlet for delivery of oxygen to said at least one reservoir; a chiller in heat exchange communication with said at least one reservoir; a fluid flow system in communication with said solution outlet, and means in communication with said fluid flow system for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body.
Claim 2
Independent Claim
100 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing an intravenously biocompatible solution within said at least one reservoir and said at least one reservoir having a solution outlet and an oxygen inlet separate from said solution outlet for delivery of oxygen to said at least one reservoir; a chiller in heat exchange communication with said at least one reservoir; a fluid flow system in communication with said solution outlet, and means in communication with said fluid flow system for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body.
Claim 3
Dependent Claim
51 words
The apparatus of claim 1, wherein said fluid flow system comprises at least one conduit in communication with said at least one reservoir, and at least one pump in communication with said at least one conduit, said at least one pump being able to regulate pressure and flow of said solution.
Claim 4
Dependent Claim
47 words
The apparatus of claim 1, wherein said fluid flow system comprises at least one conduit in communication with said at least one reservoir and at least one pump in communication with said at least one conduit, said at least one conduit being removably attachable to said apparatus.
Claim 5
Dependent Claim
17 words
The apparatus of claim 1, further comprising a source of pressurized oxygen attached to said oxygen inlet.
Claim 6
Dependent Claim
30 words
The apparatus of claim 1, wherein said means for delivering comprises at least on needle for delivering said intravenously biocompatible solution to said tissues and/or organs in said mammalian body.
Claim 7
Dependent Claim
18 words
The apparatus of claim 1, further including means for retrieving said intravenously biocompatible solution from said mammalian body.
Claim 8
Dependent Claim
19 words
The apparatus of claim 1 wherein: said at least one reservoir includes a canister having at least one compartment.
Claim 9
Dependent Claim
12 words
The apparatus of claim 7 wherein said canister is replaceable or refillable.
Claim 10
Independent Claim
83 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing a preoxygenated intravenously biocompatible solution within said at least one reservoir, said at least one reservoir having a solution outlet; a chiller in heat exchange communication with said at least one reservoir; and a fluid flow system in communication with said solution outlet, and means in communication with said fluid flow system for delivering said preoxygenated intravenously biocompatible solution to tissues and/or organs in said mammalian body.
Claim 11
Independent Claim
83 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing a preoxygenated intravenously biocompatible solution within said at least one reservoir, said at least one reservoir having a solution outlet; a chiller in heat exchange communication with said at least one reservoir; and a fluid flow system in communication with said solution outlet, and means in communication with said fluid flow system for delivering said preoxygenated intravenously biocompatible solution to tissues and/or organs in said mammalian body.
Claim 12
Dependent Claim
12 words
The apparatus of claim 9, wherein said chiller includes a heat exchanger.
Claim 13
Dependent Claim
12 words
The apparatus of claim 9, wherein said chiller includes a temperature controller.
Claim 14
Dependent Claim
18 words
The apparatus of claim 9, further including means for retrieving said intravenously biocompatible solution from said mammalian body.
Claim 15
Dependent Claim
19 words
The apparatus of claim 9 wherein: said at least one reservoir includes a canister having at least one compartment.
Claim 16
Dependent Claim
12 words
The apparatus of claim 13 wherein said canister is replaceable or refillable.
Claim 17
Dependent Claim
21 words
The apparatus of claim 9, wherein said at least one reservoir further includes an oxygen inlet separate from said solution outlet.
Claim 18
Dependent Claim
15 words
The apparatus of claim 15, further including an oxygen source connected to said oxygen inlet.
Claim 19
Dependent Claim
14 words
The apparatus of claim 16, wherein said oxygen source includes a pressurized oxygen tank.
Claim 20
Dependent Claim
36 words
The apparatus of claim 9, wherein said fluid flow system comprises at least one conduit in communication with said at least one reservoir, and at least one pump in communication with said at least one conduit.
Claim 21
Dependent Claim
14 words
The apparatus of claim 18, wherein said conduit includes a one-way balloon tip catheter.
Claim 22
Dependent Claim
27 words
The apparatus of claim 18, wherein said at least one conduit is directly connectable to the circulatory system of said mammalian body via said means for delivering.
Claim 23
Independent Claim
102 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing an intravenously biocompatible solution within said at least one reservoir, said at least one reservoir having a solution outlet and an oxygen inlet separate from said solution outlet; an oxygenator connected to said oxygen inlet; a chiller in heat exchange communication with said at least one reservoir; a fluid flow system in communication with said solution outlet of said at least one reservoir, and means in communication with said fluid flow system for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body.
Claim 24
Independent Claim
102 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing an intravenously biocompatible solution within said at least one reservoir, said at least one reservoir having a solution outlet and an oxygen inlet separate from said solution outlet; an oxygenator connected to said oxygen inlet; a chiller in heat exchange communication with said at least one reservoir; a fluid flow system in communication with said solution outlet of said at least one reservoir, and means in communication with said fluid flow system for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body.
Claim 25
Dependent Claim
12 words
The apparatus of claim 21, wherein said chiller includes a temperature controller.
Claim 26
Dependent Claim
12 words
The apparatus of claim 21, wherein said chiller includes a heat exchanger.
Claim 27
Dependent Claim
18 words
The apparatus of claim 21, further including means for retrieving said intravenously biocompatible solution from said mammalian body.
Claim 28
Dependent Claim
14 words
The apparatus of claim 21, wherein the oxygenator is connected to an oxygen source.
Claim 29
Dependent Claim
14 words
The apparatus of claim 25, wherein said oxygen source includes a pressurized oxygen tank.
Claim 30
Dependent Claim
12 words
The apparatus of claim 26, wherein said pressurized oxygen tank is adjustable.
Claim 31
Dependent Claim
47 words
The apparatus of claim 21, wherein said fluid flow system comprises at least one conduit in communication with said at least one reservoir, and at least one pump in communication with said at least one conduit, said at least one conduit being removably attachable to said apparatus.
Claim 32
Dependent Claim
24 words
The apparatus of claim 28, wherein said conduit is directly connectable to the circulatory system of said mammalian body via said means for delivering.
Claim 33
Dependent Claim
14 words
The apparatus of claim 29, wherein said conduit includes a one-way balloon tip catheter.
Claim 34
Dependent Claim
30 words
The apparatus of claim 29, wherein said means for delivering comprises at least on needle for delivering said intravenously biocompatible solution to said tissues and/or organs in said mammalian body.
Claim 35
Dependent Claim
16 words
The apparatus of claim 21, further including an oxygen source in communication with said oxygen inlet.
Claim 36
Dependent Claim
15 words
The apparatus of claim 32, wherein said oxygen source is pressurized to approximately 17 psig.
Claim 37
Dependent Claim
14 words
The apparatus of claim 32, wherein said oxygen source includes a pressurized oxygen tank.
Claim 38
Dependent Claim
12 words
The apparatus of claim 34, wherein said pressurized oxygen tank is adjustable.
Claim 39
Independent Claim
91 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing an intravenously biocompatible solution within said at least one reservoir and said at least one reservoir having a solution outlet, an oxygen inlet separate from said solution outlet for delivery of oxygen to said at least one reservoir and means in communication with said at least one reservoir for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body; and a chiller in heat exchange communication with said at least one reservoir.
Claim 40
Independent Claim
91 words
An apparatus for cooling living tissue in a mammalian body, comprising at least one reservoir containing an intravenously biocompatible solution within said at least one reservoir and said at least one reservoir having a solution outlet, an oxygen inlet separate from said solution outlet for delivery of oxygen to said at least one reservoir and means in communication with said at least one reservoir for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body; and a chiller in heat exchange communication with said at least one reservoir.
Claim 41
Dependent Claim
30 words
The apparatus of claim 36, wherein said means for delivering comprises at least on needle for delivering said intravenously biocompatible solution to said tissues and/or organs in said mammalian body.
Claim 42
Dependent Claim
18 words
The apparatus of claim 36, further including means for retrieving said intravenously biocompatible solution from said mammalian body.
Claim 43
Dependent Claim
17 words
The apparatus of claim 36, further comprising a source of pressurized oxygen attached to said oxygen inlet.
Claim 44
Dependent Claim
45 words
The apparatus of claim 39, further comprising at least one conduit in communication with said solution outlet and said means for delivering said intravenously biocompatible solution to tissues and/or organs in said mammalian body, said at least one conduit being removably attachable to said apparatus.
Claim 45
Dependent Claim
32 words
The apparatus of claim 40, further comprising a fluid flow system intermediate said solution outlet and said conduit, said fluid flow system being in communication with said solution outlet and said conduit.
Claim 46
Dependent Claim
32 words
The apparatus of claim 41, wherein said fluid flow system includes a pump, said pump being able to regulate pressure and flow of solution to tissues and/or organs in said mammalian body.
References Cited (Backward Citations)
DE221361C
Cited
US1682344A
Cited
US1916658A
Cited
US3091242A
Cited
US3406531A
Cited
US3460538A
Cited
US3632473A
Cited
SU760972A1
Cited
US4065264A
Cited
US4795423A
Cited
US4378797A
Cited
US4393863A
Cited
US5085630A
Cited
US4445500A
Cited
US4451251A
Cited
US4657532A
Cited
EP0256653A2
Cited
EP0265082A1
Cited
EP0297723A2
Cited
SU1632428A1
Cited
US5032111A
Cited
JPH01213276A
Cited
US5069661A
Cited
US5200176A
Cited
US5145771A
Cited
US5149321A
Cited
US5234405A
Cited
US5395314A
Cited
US5217860A
Cited
US5385821A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-19 | 2001-07-21 | 2002-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-19 | 2005-07-21 | 2006-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-19 | 2009-07-21 | 2010-01-20 | $7700.00 | Window Closed / Lapsed |