Patent EP0707824A2 successfully refreshed from Google Patents.
Patent US6238870B1 successfully refreshed from Google Patents.
US6238870B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nucleic acid mediated electron transfer
Assignee: California Institute of Technology
•
Filing: 1999-12-08
•
Granted: 2001-05-29
•
Expires: 2019-12-08
Abstract
Abstract The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
Inventors
- 👤 Thomas J. Meade
- 👤 Jon Faiz Kayyem
- 👤 Scott E. Fraser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:02
CPC Classifications
C; C07; C07H; C07H21/00; C07H23/00; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/6818; C12Q1/6825; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
29 words
A composition comprising a single stranded nucleic acid attached to an electrode via a three dimensional polymer matrix, wherein said nucleic acid comprises a covalently attached electron transfer moiety.
Claim 2
Dependent Claim
29 words
A composition comprising a single stranded nucleic acid attached to an electrode via a three dimensional polymer matrix, wherein said nucleic acid comprises a covalently attached electron transfer moiety.
Claim 3
Dependent Claim
12 words
A composition according to claim 1 further comprising an electron transport mediator.
Claim 4
Dependent Claim
18 words
A composition according to claim 1 or 2 wherein said electron transfer moiety is a transition metal complex.
Claim 5
Dependent Claim
23 words
A composition according to claim 3 wherein said transition metal is selected from the group consisting of ruthenium, rhenium, osmium, platinum and iron.
Claim 6
Dependent Claim
19 words
A composition according to claim 1 or 2 wherein said electron transfer moiety is an organic electron transfer moiety.
Claim 7
Dependent Claim
15 words
A composition according to claim 1 or 2 wherein said electrode is a gold electrode.
Claim 8
Dependent Claim
13 words
A composition according to claim 1 or 2 wherein said mediator is ferrocene.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-05-28 | 2004-11-27 | 2005-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-05-28 | 2008-11-27 | 2009-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-05-28 | 2012-11-27 | 2013-05-29 | $7700.00 | Window Closed / Lapsed |