US6238870B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nucleic acid mediated electron transfer
Assignee: California Institute of Technology
•
Filing: 1999-12-08
•
Granted: 2001-05-29
•
Expires: 2019-12-08
Abstract
Abstract The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
Inventors
- 👤 Thomas J. Meade
- 👤 Jon Faiz Kayyem
- 👤 Scott E. Fraser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:31
CPC Classifications
C; C07; C07H; C07H21/00; C07H23/00; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/6818; C12Q1/6825; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
29 words
A composition comprising a single stranded nucleic acid attached to an electrode via a three dimensional polymer matrix, wherein said nucleic acid comprises a covalently attached electron transfer moiety.
Claim 2
Dependent Claim
29 words
A composition comprising a single stranded nucleic acid attached to an electrode via a three dimensional polymer matrix, wherein said nucleic acid comprises a covalently attached electron transfer moiety.
Claim 3
Dependent Claim
12 words
A composition according to claim 1 further comprising an electron transport mediator.
Claim 4
Dependent Claim
18 words
A composition according to claim 1 or 2 wherein said electron transfer moiety is a transition metal complex.
Claim 5
Dependent Claim
23 words
A composition according to claim 3 wherein said transition metal is selected from the group consisting of ruthenium, rhenium, osmium, platinum and iron.
Claim 6
Dependent Claim
19 words
A composition according to claim 1 or 2 wherein said electron transfer moiety is an organic electron transfer moiety.
Claim 7
Dependent Claim
15 words
A composition according to claim 1 or 2 wherein said electrode is a gold electrode.
Claim 8
Dependent Claim
13 words
A composition according to claim 1 or 2 wherein said mediator is ferrocene.
References Cited (Backward Citations)
US5476928A
Cited
EP0063879A2
Cited
US5328824A
Cited
US4711955A
Cited
US5449767A
Cited
US5241060A
Cited
US4994373A
Cited
US4849513A
Cited
US5013831A
Cited
US4707440A
Cited
US5175269A
Cited
US4943523A
Cited
US4952685A
Cited
US4707352A
Cited
US5002885A
Cited
US4894325A
Cited
US4755458A
Cited
US5595908A
Cited
EP0229943B1
Cited
US4868103A
Cited
EP0234938A2
Cited
US5082830A
Cited
WO1989011649A1
Cited
WO1990005732A1
Cited
US5278043A
Cited
EP0515615A1
Cited
WO1992010757A1
Cited
US5552270A
Cited
WO1993010267A1
Cited
US5565552A
Cited
CA2090904A1
Cited
US5573906A
Cited
WO1993023425A1
Cited
JPH0641183A
Cited
US5312527A
Cited
US5472881A
Cited
EP0599337A2
Cited
US5741700A
Cited
US5770721A
Cited
US5756050A
Cited
US5780234A
Cited
WO1995015971A2
Cited
US5705348A
Cited
US5952172A
Cited
US5591578A
Cited
US5770369A
Cited
US5824473A
Cited
US5601982A
Cited
WO1997001646A2
Cited
WO1997027329A1
Cited
US5851772A
Cited
US5741400A
Cited
US6071699A
Cited
WO1998027229A1
Cited
WO1998028444A2
Cited
WO1998035232A2
Cited
US6089100A
Cited
JP2000238166A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-05-28 | 2004-11-27 | 2005-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-05-28 | 2008-11-27 | 2009-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-05-28 | 2012-11-27 | 2013-05-29 | $7700.00 | Window Closed / Lapsed |