US6165489A
Expired / Lapsed
US
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Crosslinked collagen compositions for in situ administration
Assignee: Angiodevice International GmbH
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Filing: 1999-04-28
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Granted: 2000-12-26
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Expires: 2019-04-28
Abstract
Abstract The present invention discloses a novel, injectable crosslinked collagen composition which is able to continue crosslinking after injection to a soft or hard tissue site in order to anchor the collagen implant to the host tissue. The composition comprises particulate crosslinked collagen, noncrosslinked collagen (which may be fibrillar or nonfibrillar collagen), and a chemical crosslinking agent, such as synthetic hydrophilic polymer. Methods of augmenting soft or hard tissue using these injectable collagen compositions are also disclosed.
Inventors
- 👤 Richard A. Berg
- 👤 Joel S. Rosenblatt
- 👤 Woonza M. Rhee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:33
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61L; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L27/00; A61L27/14; A61L27/18; A61L27/22; A61L27/24; A61L31/00; A61L31/04; A61L31/043; A61L31/044; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
46 words
An injectable collagen composition comprising particulate crosslinked collagen, noncrosslinked collagen, and a multifunctionally activated synthetic hydrophilic polymer having two or more functional groups capable of reacting with primary amino groups on collagen molecules to form a crosslinked matrix between the crosslinked collagen and the noncrosslinked collagen.
Claim 2
Dependent Claim
46 words
An injectable collagen composition comprising particulate crosslinked collagen, noncrosslinked collagen, and a multifunctionally activated synthetic hydrophilic polymer having two or more functional groups capable of reacting with primary amino groups on collagen molecules to form a crosslinked matrix between the crosslinked collagen and the noncrosslinked collagen.
Claim 3
Dependent Claim
27 words
The composition of claim 1, wherein the particulate crosslinked collagen is crosslinked using a method selected from the group consisting of: heat, irradiation, and chemical crosslinking agents.
Claim 4
Dependent Claim
35 words
The composition of claim 2, wherein the particulate crosslinked collagen is crosslinked using a chemical crosslinking agent selected from the group consisting of: aldheydes, divinyl sulfone, epoxides, carbodiimides, imidazole, synthetic hydrophilic polymers, and mixtures thereof.
Claim 5
Dependent Claim
13 words
The composition of claim 3, wherein the particulate crosslinked collagen is glutaraldehyde-crosslinked collagen.
Claim 6
Dependent Claim
21 words
The composition of claim 1, wherein the particulate crosslinked collagen comprises between about 25% and 95% by weight of the composition.
Claim 7
Dependent Claim
21 words
The composition of claim 1, wherein the particulate crosslinked collagen comprises between 60% to about 80% by weight of the composition.
Claim 8
Dependent Claim
12 words
The composition of claim 1, wherein the noncrosslinked collagen is atelopeptide collagen.
Claim 9
Dependent Claim
12 words
The composition of claim 1, wherein the noncrosslinked collagen is fibrillar collagen.
Claim 10
Dependent Claim
21 words
The composition of claim 8, wherein the noncrosslinked collagen comprises between about 5% to about 75% by weight of the composition.
Claim 11
Dependent Claim
21 words
The composition of claim 9, wherein the noncrosslinked collagen comprises between about 20% to about 40% by weight of the composition.
Claim 12
Dependent Claim
37 words
The composition of claim 1, wherein the multifunctionally activated synthetic hydrophilic polymer is selected from the group consisting of multifunctionally activated derivatives of: polyethylene glycol, polyoxyethylene, polymethylene glycol, polytrimethylene glycols, polyvinylpyrrolidones, and polyoxyethylene-polyoxypropylene block polymers and copolymers.
Claim 13
Dependent Claim
20 words
The composition of claim 11, wherein the multifunctionally activated synthetic hydrophilic polymer is a multifunctionally activated derivative of polyethylene glycol.
Claim 14
Dependent Claim
29 words
The composition of claim 12, wherein the multifunctionally activated polyethylene glycol derivative is selected from the group consisting of; polyethylene glycol succinimidyl glutarate, succinimidyl, succinimidyl succinamide, and succinimidyl carbonate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-26 | 2004-06-26 | 2004-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-26 | 2008-06-26 | 2008-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-26 | 2012-06-26 | 2012-12-26 | $7700.00 | Window Closed / Lapsed |