Patent US6135976A successfully refreshed from Google Patents.
US6135976A
Expired / Lapsed
US
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Method, device and kit for performing gene therapy
Assignee: Ekos LLC
•
Filing: 1998-09-25
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Granted: 2000-10-24
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Expires: 2018-09-25
Abstract
Abstract A catheter is provided for performing gene therapy on a selected section of a body lumen. The catheter comprises a distal catheter body including one or more expandable members for occluding sections of the body lumen proximal and/or distal to the selected section of the body lumen; a gene therapy composition delivery lumen connected to one or more gene therapy composition delivery ports at the distal catheter body for delivering a gene therapy composition to the selected section of the body lumen, the gene therapy composition delivery lumen housing a gene therapy agent; a washing lumen connected to one or more washing ports for delivering fluid to wash the selected section of the body lumen; and an ultrasound transducer for delivering ultrasound energy to the selected section of the body lumen.
Inventors
- 👤 Cozier Tachibana
- 👤 Douglas R. Hansmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:13
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0092; A61K; A61K41/00; A61K41/0028; A61K47/00; A61K47/50; A61K47/69; A61K47/6957; A61M25/00; A61M25/0043; A61M2025/0057; A61M25/10; A61M2025/1043; A61M2025/105; A61M2025/1086; A61M25/1011
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
113 words
A method for performing gene therapy on a selected section of a body lumen comprising: placing within a selected section of the body lumen a catheter including one or more expandable members for occluding sections of the body lumen proximal and/or distal to the selected section; occluding sections of the body lumen proximal and/or distal to the selected section of the body lumen; delivering a gene therapy composition into the selected section of the body lumen; and delivering ultrasound to the selected section of the body lumen for a period of time in the presence of the gene therapy composition under conditions where the ultrasound causes cavitation of cells in the selected section.
Claim 2
Independent Claim
113 words
A method for performing gene therapy on a selected section of a body lumen comprising: placing within a selected section of the body lumen a catheter including one or more expandable members for occluding sections of the body lumen proximal and/or distal to the selected section; occluding sections of the body lumen proximal and/or distal to the selected section of the body lumen; delivering a gene therapy composition into the selected section of the body lumen; and delivering ultrasound to the selected section of the body lumen for a period of time in the presence of the gene therapy composition under conditions where the ultrasound causes cavitation of cells in the selected section.
Claim 3
Dependent Claim
49 words
The method according to claim 1 wherein the catheter includes an expandable member for occluding a section of the body lumen proximal to the selected section of the body lumen, the method including occluding a section of the body lumen proximal to the selected section of the body lumen.
Claim 4
Dependent Claim
49 words
The catheter according to claim 1 wherein the catheter includes an expandable member for occluding a section of the body lumen distal to the selected section of the body lumen, the method including occluding a section of the body lumen distal to the selected section of the body lumen.
Claim 5
Dependent Claim
71 words
The method according to claim 1 wherein the catheter includes an expandable member for occluding a section of the body lumen proximal to the selected section of the body lumen and an expandable member for occluding a section of the body lumen distal to the selected section of the body lumen, the method including occluding sections of the body lumen proximal and distal to the selected section of the body lumen.
Claim 6
Dependent Claim
36 words
The method according to claim 1 wherein the method further includes the step of washing the selected section of the body lumen before delivering the gene therapy composition into the selected section of the body lumen.
Claim 7
Dependent Claim
20 words
The method according to claim 5 wherein the method further includes the step of delivering ultrasound during the washing step.
Claim 8
Dependent Claim
48 words
The method according to claim 1 wherein the method further includes the step of washing the selected section of the body lumen after delivering the gene therapy composition into the selected section of the body lumen in order to remove the gene therapy composition from the body lumen.
Claim 9
Dependent Claim
20 words
The method according to claim 7 wherein the method further includes the step of delivering ultrasound during the washing step.
Claim 10
Dependent Claim
25 words
The method according to claim 1 wherein the gene therapy agent is selected from the group consisting of DNA and RNA viral vectors and plasmids.
Claim 11
Dependent Claim
16 words
The method according to claim 1 wherein the gene therapy composition further includes a microbubble booster.
Claim 12
Dependent Claim
17 words
The method according to claim 1 wherein the gene therapy composition further includes a gene therapy carrier.
Claim 13
Dependent Claim
24 words
The method according to claim 1 wherein the step of delivering ultrasound is performed intermittantly with the step of delivering the gene therapy composition.
Claim 14
Dependent Claim
28 words
The method according to claim 12 wherein the step of delivering ultrasound intermittantly includes ceasing delivery of ultrasound for periods of time at least 0.1 second in duration.
Claim 15
Dependent Claim
56 words
The method according to claim 12 wherein the step of delivering ultrasound intermittantly includes ceasing delivery of ultrasound for periods of time sufficient for a bolus of the gene therapy composition to be delivered from a location in the catheter where the composition is not affected by the prior delivery of ultrasound to the selected section.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-24 | 2004-04-24 | 2004-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-24 | 2008-04-24 | 2008-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-24 | 2012-04-24 | 2012-10-24 | $7700.00 | Window Closed / Lapsed |