US5267985A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery by multiple frequency phonophoresis
Assignee: Trancell Inc
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Filing: 1993-02-11
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Granted: 1993-12-07
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Expires: 2013-02-11
Abstract
Abstract The present invention provides a method and apparatus for enhancing the diffusion of a substance to a local area of material or tissue by providing ultrasonic energy to the substance and material in two or more distinct frequencies simultaneously. Each of the distinct frequencies of ultrasonic energy is chosen to enhance permeation of the substance through one or more diffusion rate-limiting sections of the material.
Inventors
- 👤 Jin Shimada
- 👤 James E. Shapland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:57
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0092
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
89 words
A method of enhancing diffusion of a substance through material comprising the steps of: a) providing said substance proximate said material; b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency; c) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency, said second frequency differing from said first frequency, whereby diffusion of said substance through said material is enhanced.
Claim 2
Independent Claim
89 words
A method of enhancing diffusion of a substance through material comprising the steps of: a) providing said substance proximate said material; b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency; c) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency, said second frequency differing from said first frequency, whereby diffusion of said substance through said material is enhanced.
Claim 3
Dependent Claim
27 words
The method of claim 1, further comprising the step of selecting said first frequency to enhance diffusion of said substance through a first portion of said material.
Claim 4
Dependent Claim
18 words
The method of claim 2, wherein said first portion of said material is a diffusion rate limiting membrane.
Claim 5
Dependent Claim
27 words
The method of claim 2, wherein said material is living tissue and further wherein said first portion of said material is a stratum corneum layer of skin.
Claim 6
Dependent Claim
19 words
The method of claim 4, wherein said first frequency lies in the range of 10 kHz to 100 MHz.
Claim 7
Dependent Claim
27 words
The method of claim 1, further comprising the step of selecting said second frequency to enhance diffusion of said substance through a second portion of said material.
Claim 8
Dependent Claim
16 words
The method of claim 6, wherein said material is living tissue below a layer of skin.
Claim 9
Dependent Claim
17 words
The method of claim 7, wherein said second frequency lies in the range of 100 Hz-20 MHz.
Claim 10
Dependent Claim
20 words
The method of claim 1, wherein said first and second components of ultrasonic energy are provided by a single transducer.
Claim 11
Dependent Claim
22 words
The method of claim 1, wherein said first and second components of ultrasonic energy are provided, respectively, by first and second transducers.
Claim 12
Independent Claim
123 words
A method of enhancing diffusion of a substance through material comprising the steps of: a) providing said substance proximate said material; b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency; c) selecting said first frequency to enhance diffusion of said substance through a first portion of said material; d) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency; e) selecting said second frequency to enhance diffusion of said substance through a second portion of said material, whereby diffusion of said substance throughout said first and second portions of said material is enhanced.
Claim 13
Independent Claim
123 words
A method of enhancing diffusion of a substance through material comprising the steps of: a) providing said substance proximate said material; b) providing a first component of ultrasonic energy to said substance, said first component of ultrasonic energy having a first frequency; c) selecting said first frequency to enhance diffusion of said substance through a first portion of said material; d) providing a second component of ultrasonic energy to said substance simultaneous with said first component of ultrasonic energy, said second component of ultrasonic energy having a second frequency; e) selecting said second frequency to enhance diffusion of said substance through a second portion of said material, whereby diffusion of said substance throughout said first and second portions of said material is enhanced.
Claim 14
Dependent Claim
20 words
The method of claim 11, wherein said first and second components of ultrasonic energy are provided by a single transducer.
Claim 15
Dependent Claim
22 words
The method of claim 11, wherein said first and second components of ultrasonic energy are provided, respectively, by first and second transducers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-12-06 | 1997-06-07 | 1997-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-12-06 | 2001-06-07 | 2001-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-12-06 | 2005-06-07 | 2005-12-07 | $7700.00 | Window Closed / Lapsed |