US5767152A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and methods for stimulating hair growth
Assignee: Sn Biotech Inc
•
Filing: 1995-05-04
•
Granted: 1998-06-16
•
Expires: 2015-05-04
Abstract
Abstract A method for regulation of hair growth in an adult mammal, in which a trichogenic composition is applied to the skin. Also disclosed are methods for inducing skin differentiation and stimulating hair growth, wherein a formulation of a trichogenic composition is applied to the skin.
Inventors
- 👤 Thor Bagger Nielsen
- 👤 Liying Sun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 10:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/275; A61K31/277
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
174 words
A method for treating a mammal to induce or promote hair growth, hair follicle differentiation and development, melanogenesis, hair shaft elongation, skin cell differentiation or proliferation, or a shift in hair growth cycle from telogen to anagen comprising applying to a layer of viable skin of said mammal an effective amount of a pharmaceutically acceptable composition comprising a cyanocarboxylic acid derivative having the formula: ##STR5## wherein R 1 is alkyl containing 1 to 20 carbons, cycloalkyl containing up to 20 carbons, alkenyl containing up to 20 carbons, alkynyl containing up to 20 carbons, aryl containing up to 20 carbons, alkaryl containing up to 20 carbons, aralkyl containing up to 20 carbons, or mono- or poly-alkoxyalkyl containing up to 20 carbons; and R 2 is alkyl containing 1 to 10 carbons, cycloalkyl containing up to 10 carbons, alkenyl containing up to 10 carbons, alkoxyalkenyl containing up to 10 carbons, alkynyl containing up to 10 carbons, aryl containing up to 10 carbons, alkaryl containing up to 10 carbons, aralkyl containing up to 10 carbons, or H.
Claim 2
Independent Claim
174 words
A method for treating a mammal to induce or promote hair growth, hair follicle differentiation and development, melanogenesis, hair shaft elongation, skin cell differentiation or proliferation, or a shift in hair growth cycle from telogen to anagen comprising applying to a layer of viable skin of said mammal an effective amount of a pharmaceutically acceptable composition comprising a cyanocarboxylic acid derivative having the formula: ##STR5## wherein R 1 is alkyl containing 1 to 20 carbons, cycloalkyl containing up to 20 carbons, alkenyl containing up to 20 carbons, alkynyl containing up to 20 carbons, aryl containing up to 20 carbons, alkaryl containing up to 20 carbons, aralkyl containing up to 20 carbons, or mono- or poly-alkoxyalkyl containing up to 20 carbons; and R 2 is alkyl containing 1 to 10 carbons, cycloalkyl containing up to 10 carbons, alkenyl containing up to 10 carbons, alkoxyalkenyl containing up to 10 carbons, alkynyl containing up to 10 carbons, aryl containing up to 10 carbons, alkaryl containing up to 10 carbons, aralkyl containing up to 10 carbons, or H.
Claim 3
Dependent Claim
15 words
The method according to claim 1, wherein the cyanocarboxylic acid derivative has the formula: ##STR6##
Claim 4
Dependent Claim
15 words
The method according to claim 1, wherein the cyanocarboxylic acid derivative has the formula: ##STR7##
Claim 5
Dependent Claim
35 words
The method of claim 1, wherein an effective amount of the pharmaceutically acceptable composition is applied topically, intradermally, subcutaneously, or via dermal patch or slow-release mechanism to the layer of viable skin of the mammal.
Claim 6
Dependent Claim
11 words
The method of claim 4, wherein the mammal is a human.
Claim 7
Dependent Claim
11 words
The method of claim 4, wherein the mammal is a sheep.
Claim 8
Dependent Claim
23 words
The method of claim 4, wherein the pharmaceutically acceptable composition is applied in vitro to a layer of viable skin of the mammal.
Claim 9
Dependent Claim
29 words
The method according to claim 1, wherein the cyanocarboxylic acid derivative comprises from 0.0001 to 99% by weight of the pharmaceutically acceptable composition, and a pharmaceutically acceptable vehicle therefor.
Claim 10
Dependent Claim
21 words
The method of claim 8, wherein the cyanocarboxylic acid derivative comprises at least 25% by weight of the pharmaceutically acceptable composition.
Claim 11
Dependent Claim
21 words
The method of claim 8, wherein the cyanocarboxylic acid derivative comprises at least 50% by weight of the pharmaceutically acceptable composition.
Claim 12
Dependent Claim
27 words
A method according to claim 4, wherein the composition is applied to the skin by topical spray, shampoo, cream, ointment, salve, powder, sprayed powder, or the like.
Claim 13
Dependent Claim
21 words
The method of claim 1, wherein the composition is applied in vitro to a layer of viable skin of the mammal.
Claim 14
Dependent Claim
30 words
The method of claim 1, wherein the pharmaceutically acceptable composition is applied in vitro to a layer of viable skin of a mammal from which fur is to be obtained.
Claim 15
Independent Claim
185 words
A method for treating a mammal to induce or promote hair growth, hair follicle differentiation and development, melanogenesis, hair shaft elongation, skin cell differentiation or proliferation, or a shift in hair growth cycle from telogen to anagen comprising applying to a layer of viable skin of said mammal an effective amount of a pharmaceutically acceptable composition comprising a cyanocarboxylic acid derivative having the formula: ##STR8## wherein R 1 forms an alkyl amide containing 1 to 20 carbons, an dialkyl amide containing up to 20 carbons, an alkoxyalkylamide containing up to 20 carbons, an anhydride containing up to 20 carbons, or an acyl halide containing up to 20 carbons, or R 1 is NH 2 , and R 2 is alkyl containing 1 to 10 carbons, cycloalkyl containing up to 10 carbons, alkenyl containing up to 10 carbons, alkoxyalkenyl containing up to 10 carbons, alkynyl containing up to 10 carbons, aryl containing up to 10 carbons, alkaryl containing up to 10 carbons, aralkyl containing up to 10 carbons, or H, with the proviso that when R 1 is NH 2 , R 2 is not aryl.
Claim 16
Independent Claim
185 words
A method for treating a mammal to induce or promote hair growth, hair follicle differentiation and development, melanogenesis, hair shaft elongation, skin cell differentiation or proliferation, or a shift in hair growth cycle from telogen to anagen comprising applying to a layer of viable skin of said mammal an effective amount of a pharmaceutically acceptable composition comprising a cyanocarboxylic acid derivative having the formula: ##STR8## wherein R 1 forms an alkyl amide containing 1 to 20 carbons, an dialkyl amide containing up to 20 carbons, an alkoxyalkylamide containing up to 20 carbons, an anhydride containing up to 20 carbons, or an acyl halide containing up to 20 carbons, or R 1 is NH 2 , and R 2 is alkyl containing 1 to 10 carbons, cycloalkyl containing up to 10 carbons, alkenyl containing up to 10 carbons, alkoxyalkenyl containing up to 10 carbons, alkynyl containing up to 10 carbons, aryl containing up to 10 carbons, alkaryl containing up to 10 carbons, aralkyl containing up to 10 carbons, or H, with the proviso that when R 1 is NH 2 , R 2 is not aryl.
Claim 17
Dependent Claim
35 words
The method of claim 14, wherein an effective amount of the pharmaceutically acceptable composition is applied topically, intradermally, subcutaneously, or via dermal patch or slow-release mechanism to the layer of viable skin of the mammal.
Claim 18
Dependent Claim
11 words
The method of claim 15, wherein the mammal is a human.
Claim 19
Dependent Claim
11 words
The method of claim 15, wherein the mammal is a sheep.
Claim 20
Dependent Claim
23 words
The method of claim 15, wherein the pharmaceutically acceptable composition is applied in vitro to a layer of viable skin of the mammal.
Claim 21
Dependent Claim
29 words
The method according to claim 14, wherein the cyanocarboxylic acid derivative comprises from 0.0001 to 99% by weight of the pharmaceutically acceptable composition, and a pharmaceutically acceptable vehicle therefor.
Claim 22
Dependent Claim
21 words
The method of claim 19, wherein the cyanocarboxylic acid derivative comprises at least 25% by weight of the pharmaceutically acceptable composition.
Claim 23
Dependent Claim
21 words
The method of claim 19, wherein the cyanocarboxylic acid derivative comprises at least 50% by weight of the pharmaceutically acceptable composition.
Claim 24
Dependent Claim
27 words
A method according to claim 15, wherein the composition is applied to the skin by topical spray, shampoo, cream, ointment, salve, powder, sprayed powder, or the like.
Claim 25
Dependent Claim
21 words
The method of claim 14, wherein the composition is applied in vitro to a layer of viable skin of the mammal.
Claim 26
Dependent Claim
30 words
The method of claim 14, wherein the pharmaceutically acceptable composition is applied in vitro to a layer of viable skin of a mammal from which fur is to be obtained.
Claim 27
Independent Claim
222 words
A method for treating a mammal to induce or promote hair growth, hair follicle differentiation and development, melanogenesis, hair shaft elongation, skin cell differentiation or proliferation, or a shift in hair growth cycle from telogen to anagen comprising applying to a layer of viable skin of said mammal an effective amount of a pharmaceutically acceptable composition comprising a cyanocarboxylic acid derivative selected from the group consisting of: ethoxyethyl 2-cyanoacrylate, butoxyethyl 2-cyanoacrylate, n-butyl 2-cyanoacrylate, isobutyl 2-cyanoacrylate, n-propyl 2-cyanoacrylate, isopropyl 2-cyanoacrylate, n-hexyl 2-cyanoacrylate, isohexyl 2-cyanoacrylate, cyclohexyl 2-cyanoacrylate, benzyl 2-cyanoacrylate, glycerol 2-cyanoacrylate, ethoxybutyl 2-cyanoacrylate, n-pentyl 2-cyanoacrylate, isopentyl 2-cyanoacrylate, n-heptyl 2-cyanoacrylate, isoheptyl 2-cyanoacrylate, n-octyl 2-cyanoacrylate, isooctyl 2-cyanoacrylate, n-nonyl 2-cyanoacrylate, isononyl 2-cyanoacrylate, n-decyl 2-cyanoacrylate, isodecyl 2-cyanoacrylate, n-butyl 2-cyano-3-methoxyacrylate, isobutyl 2-cyano-3-methoxyacrylate, n-butyl 2-cyano-3-phenylacrylate, isobutyl 2-cyano-3-phenylacrylate, n-butyl 2-cyano-2-butenoate, isobutyl 2-cyano-2-butenoate, n-butyl 2-cyano-2-pentenoate, isobutyl 2-cyano-2-pentenoate, n-butyl 2-cyano-2-hexenoate, isobutyl 2-cyano-2-hexenoate, n-butyl 2-cyano-2-heptenoate, isobutyl 2-cyano-2-heptenoate, n-butyl 2-cyano-2-octenoate, isobutyl 2-cyano-2-octenoate, n-butyl 2-cyano-2-nonenoate, isobutyl 2-cyano-2-nonenoate, n-butyl 2-cyano-2-decenoate, isobutyl 2-cyano-2-decenoate, N-propyl 2-cyanoacrylamide, N-butyl 2-cyanoacrylamide, N-pentyl 2-cyanoacrylamide, N-hexyl 2-cyanoacrylamide, N-heptyl 2-cyanoacrylamide, N-octyl 2-cyanoacrylamide, N-nonyl 2-cyanoacrylamide, N-decyl 2-cyanoacrylamide, N-benzyl 2-cyanoacrylamide, N-cyclohexyl 2-cyanoacrylamide, N-ethoxyethyl 2-cyanoacrylamide, N-ethoxypropyl 2-cyanoacrylamide, N-ethoxybutyl 2-cyanoacrylamide, N-ethoxypentyl 2-cyanoacrylamide, N-ethoxyhexyl 2-cyanoacrylamide, N-ethoxyheptyl 2-cyanoacrylamide, N-ethoxyoctyl 2-cyanoacrylamide, N-ethoxynonyl 2-cyanoacrylamide, N-ethoxydecyl 2-cyanoacrylamide, N-propoxyethyl 2-cyanoacrylamide, N-propoxypropyl 2-cyanoacrylamide, N-propoxybutyl 2-cyanoacrylamide, N-propoxypentyl 2-cyanoacrylamide, N-propoxyhexyl 2-cyanoacrylamide, N-propoxyheptyl 2-cyanoacrylamide, N-propoxyoctyl 2-cyanoacrylamide, N-propoxynonyl 2-cyanoacrylamide, N-propoxydecyl 2-cyanoacrylamide, N-butoxyethyl 2-cyanoacrylamide, N-butoxypropyl 2-cyanoacrylamide, N-butoxybutyl 2-cyanoacrylamide, N-butoxypentyl 2-cyanoacrylamide, N-butoxyhexyl 2-cyanoacrylamide, N-butoxyheptyl 2-cyanoacrylamide, N-butoxyoctyl 2-cyanoacrylamide, N-butoxynonyl 2-cyanoacrylamide, and N-butoxydecyl 2-cyanoacrylamide.
Claim 28
Independent Claim
222 words
A method for treating a mammal to induce or promote hair growth, hair follicle differentiation and development, melanogenesis, hair shaft elongation, skin cell differentiation or proliferation, or a shift in hair growth cycle from telogen to anagen comprising applying to a layer of viable skin of said mammal an effective amount of a pharmaceutically acceptable composition comprising a cyanocarboxylic acid derivative selected from the group consisting of: ethoxyethyl 2-cyanoacrylate, butoxyethyl 2-cyanoacrylate, n-butyl 2-cyanoacrylate, isobutyl 2-cyanoacrylate, n-propyl 2-cyanoacrylate, isopropyl 2-cyanoacrylate, n-hexyl 2-cyanoacrylate, isohexyl 2-cyanoacrylate, cyclohexyl 2-cyanoacrylate, benzyl 2-cyanoacrylate, glycerol 2-cyanoacrylate, ethoxybutyl 2-cyanoacrylate, n-pentyl 2-cyanoacrylate, isopentyl 2-cyanoacrylate, n-heptyl 2-cyanoacrylate, isoheptyl 2-cyanoacrylate, n-octyl 2-cyanoacrylate, isooctyl 2-cyanoacrylate, n-nonyl 2-cyanoacrylate, isononyl 2-cyanoacrylate, n-decyl 2-cyanoacrylate, isodecyl 2-cyanoacrylate, n-butyl 2-cyano-3-methoxyacrylate, isobutyl 2-cyano-3-methoxyacrylate, n-butyl 2-cyano-3-phenylacrylate, isobutyl 2-cyano-3-phenylacrylate, n-butyl 2-cyano-2-butenoate, isobutyl 2-cyano-2-butenoate, n-butyl 2-cyano-2-pentenoate, isobutyl 2-cyano-2-pentenoate, n-butyl 2-cyano-2-hexenoate, isobutyl 2-cyano-2-hexenoate, n-butyl 2-cyano-2-heptenoate, isobutyl 2-cyano-2-heptenoate, n-butyl 2-cyano-2-octenoate, isobutyl 2-cyano-2-octenoate, n-butyl 2-cyano-2-nonenoate, isobutyl 2-cyano-2-nonenoate, n-butyl 2-cyano-2-decenoate, isobutyl 2-cyano-2-decenoate, N-propyl 2-cyanoacrylamide, N-butyl 2-cyanoacrylamide, N-pentyl 2-cyanoacrylamide, N-hexyl 2-cyanoacrylamide, N-heptyl 2-cyanoacrylamide, N-octyl 2-cyanoacrylamide, N-nonyl 2-cyanoacrylamide, N-decyl 2-cyanoacrylamide, N-benzyl 2-cyanoacrylamide, N-cyclohexyl 2-cyanoacrylamide, N-ethoxyethyl 2-cyanoacrylamide, N-ethoxypropyl 2-cyanoacrylamide, N-ethoxybutyl 2-cyanoacrylamide, N-ethoxypentyl 2-cyanoacrylamide, N-ethoxyhexyl 2-cyanoacrylamide, N-ethoxyheptyl 2-cyanoacrylamide, N-ethoxyoctyl 2-cyanoacrylamide, N-ethoxynonyl 2-cyanoacrylamide, N-ethoxydecyl 2-cyanoacrylamide, N-propoxyethyl 2-cyanoacrylamide, N-propoxypropyl 2-cyanoacrylamide, N-propoxybutyl 2-cyanoacrylamide, N-propoxypentyl 2-cyanoacrylamide, N-propoxyhexyl 2-cyanoacrylamide, N-propoxyheptyl 2-cyanoacrylamide, N-propoxyoctyl 2-cyanoacrylamide, N-propoxynonyl 2-cyanoacrylamide, N-propoxydecyl 2-cyanoacrylamide, N-butoxyethyl 2-cyanoacrylamide, N-butoxypropyl 2-cyanoacrylamide, N-butoxybutyl 2-cyanoacrylamide, N-butoxypentyl 2-cyanoacrylamide, N-butoxyhexyl 2-cyanoacrylamide, N-butoxyheptyl 2-cyanoacrylamide, N-butoxyoctyl 2-cyanoacrylamide, N-butoxynonyl 2-cyanoacrylamide, and N-butoxydecyl 2-cyanoacrylamide.
References Cited (Backward Citations)
US4596812A
Cited
US4874791A
Cited
US4978681A
Cited
US5096697A
Cited
US4866038A
Cited
US4918055A
Cited
US5157036A
Cited
US4937232A
Cited
US5026691A
Cited
US4814351A
Cited
US5053410A
Cited
US5049547A
Cited
US5185325A
Cited
US5055456A
Cited
US5158955A
Cited
US5124354A
Cited
US5229271A
Cited
US5326690A
Cited
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