US5124354A
Expired / Lapsed
US
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Cosmetic composition containing an aryl-substituted ethylene
Assignee: Chesebrough Ponds USA Inc
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Filing: 1990-06-11
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Granted: 1992-06-23
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Expires: 2010-06-11
Abstract
Abstract A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a special protein tyrosine kinase inhibitor; and (ii) a cosmetically acceptable vehicle for the inhibitor.
Inventors
- 👤 Martin R. Green
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:43
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/42; A61K8/33; A61K8/36; A61K8/365; A61K8/46; A61Q; A61Q7/00; A61K2800/00; A61K2800/74; A61K2800/78; A61K2800/782
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
134 words
A method of inhibiting phase transition from anagen to catagen in mammalian hair growth, comprising applying to hair or skin in a region of the scalp a composition which comprises: (i) as a protein tyrosine kinase inhibitor from 0.0001 to 99% by weight of an aryl-substituted ethylene having the structure (1) ##STR45## where R 1 , R 2 , R 3 and R 4 are the same or different, and are selected from a group consisting of ##STR46## where R 5 and R 6 are the same or different, and are selected from a group consisting of ##STR47## where R 7 is chosen from --H and --OH; and where n is an integer of from 1 to 8; and (ii) from 1 to 99.999% by weight of a cosmetically acceptable vehicle for the inhibitor.
Claim 2
Independent Claim
134 words
A method of inhibiting phase transition from anagen to catagen in mammalian hair growth, comprising applying to hair or skin in a region of the scalp a composition which comprises: (i) as a protein tyrosine kinase inhibitor from 0.0001 to 99% by weight of an aryl-substituted ethylene having the structure (1) ##STR45## where R 1 , R 2 , R 3 and R 4 are the same or different, and are selected from a group consisting of ##STR46## where R 5 and R 6 are the same or different, and are selected from a group consisting of ##STR47## where R 7 is chosen from --H and --OH; and where n is an integer of from 1 to 8; and (ii) from 1 to 99.999% by weight of a cosmetically acceptable vehicle for the inhibitor.
Claim 3
Dependent Claim
28 words
A method according to claim 1, in which the inhibitor is chosen from those in structure (1) where R is a C 1 to C 20 alkyl group.
Claim 4
Dependent Claim
39 words
A method according to claim 1 in which the inhibitor is chosen from: 1-carboxy-2-(4-hydroxyphenyl)ethylene 1,1-dicarboxy-2-(4-hydroxyphenyl)ethylene 1,1-dicyano-2-(4-hydroxyphenyl)ethylene 1-carboxy-2-(3,4-dihydroxyphenyl)ethylene 1,1-dicyano-2-(3-hydroxyphenyl)ethylene 1-cyano-1-carboxy-2-(2,5-dihydroxyphenyl)ethylene 1-carboxy-1-cyano-2-(3,4-dihydroxphenyl)ethylene 1,1-dicyano-2-(3,4-dihydroxyphenyl)ethylene 1,1-dicyano-2-(3-methoxy-4,5-dihydroxyphenyl)ethylene 1,1-dicyano-2-(3,4,5-trihydroxyphenyl)ethylene 1-amido-1-cyano-2-(3,4-dihydroxyphenyl)ethylene 1-thioamido-1-cyano-2-(3,4-dihydroxyphenyl)ethylene 1-cyano-2-(4-hydroxyphenyl)ethylene 1,1-dicyano-2-(3-hydroxy-4-nitrophenyl)ethylene 1,1-dicyano-2-hydroxy-2-(4-hydroxyphenyl)ethyl<ne 1,1-dicyano-2-(3-methoxy-4-hydroxyphenyl)ethylene 1,1-dicyano-2-(3,5-dihydroxyphenyl)ethylene 1,1-dicyano-2-hydroxy-2-(3,4,5-trihydroxyphenyl)ethylene 1-carboxy-1-cyano-2-(4-methoxyphenyl)ethylene 1-carboxy-1-cyano-2-(4-fluorophenyl)ethylene 1-carboxy-1-cyano-2-(3-methoxy-4-hydroxyphenyl)ethylene 1-carboxy-1-cyano-2-(3,5-dimethoxy-4-hydroxyphenylethylene 1-carboxy-1-cyano-2-(4-hydroxyphenyl)ethylene 1-carboxy-1-cyano-2-(4-phenylcarboxyaldehyde)ethylene, and 1-cyano-1-carboxy-2-(2,5-dihydroxyphenyl)ethylene
Claim 5
Dependent Claim
20 words
A method according to claim 1 in which the inhibitor forms from 0.01 to 20% by weight of the composition.
Claim 6
Dependent Claim
21 words
A method according to claim 1, further comprising minoxidil present in an effective amount to function as a hair growth stimulant.
Claim 7
Dependent Claim
22 words
A method according to claim 1, further comprising a surface active agent present in an effective amount to function as a surfactant.
Claim 8
Dependent Claim
22 words
A method according to claim 1, further comprising a cationic polymer present in an effective amount to enhance activity of the inhibitor.
Claim 9
Dependent Claim
18 words
A method according to claim 1, wherein the composition has a pH value of from 2 to <7.
Claim 10
Dependent Claim
13 words
A method according to claim 1 which is a shampoo or hair conditioner.
Claim 11
Independent Claim
131 words
A method of prolonging anagen phase in growth of mammalian hair, comprising applying to hair or skin in a region of the scalp a composition which comprises: (i) as a protein tyrosine kinase inhibitor from 0.0001 to 99% by weight of an aryl-substituted ethylene having the structure (1) ##STR48## where R 1 , R 2 , R 3 and R 4 are the same or different, and are selected from a group consisting of ##STR49## where R 5 and R 6 are the same or different, and are selected from a group consisting of ##STR50## where R 7 is chosen from --H and --OH; and where n is an integer of from 1 to 8; and (ii) from 1 to 99.999% by weight of a cosmetically acceptable vehicle for the inhibitor.
Claim 12
Independent Claim
131 words
A method of prolonging anagen phase in growth of mammalian hair, comprising applying to hair or skin in a region of the scalp a composition which comprises: (i) as a protein tyrosine kinase inhibitor from 0.0001 to 99% by weight of an aryl-substituted ethylene having the structure (1) ##STR48## where R 1 , R 2 , R 3 and R 4 are the same or different, and are selected from a group consisting of ##STR49## where R 5 and R 6 are the same or different, and are selected from a group consisting of ##STR50## where R 7 is chosen from --H and --OH; and where n is an integer of from 1 to 8; and (ii) from 1 to 99.999% by weight of a cosmetically acceptable vehicle for the inhibitor.
Claim 13
Independent Claim
135 words
A method of inhibiting a transition in mammalian hair growth from terminal to vellus hair, comprising applying to hair or skin in a region of the scalp a composition which comprises: (i) as a protein tyrosine kinase inhibitor from 0.0001 to 99% by weight of an aryl-substituted ethylene having the structure (1) ##STR51## where R 1 , R 2 , R 3 and R 4 are the same or different, and are selected from a group consisting of ##STR52## where R 5 and R 6 are the same or different, and are selected from a group consisting of ##STR53## where R 7 is chosen from --H and --OH; and where n is an integer of from 1 to 8; and (ii) from 1 to 99.999% by weight of a cosmetically acceptable vehicle for the inhibitor.
Claim 14
Independent Claim
135 words
A method of inhibiting a transition in mammalian hair growth from terminal to vellus hair, comprising applying to hair or skin in a region of the scalp a composition which comprises: (i) as a protein tyrosine kinase inhibitor from 0.0001 to 99% by weight of an aryl-substituted ethylene having the structure (1) ##STR51## where R 1 , R 2 , R 3 and R 4 are the same or different, and are selected from a group consisting of ##STR52## where R 5 and R 6 are the same or different, and are selected from a group consisting of ##STR53## where R 7 is chosen from --H and --OH; and where n is an integer of from 1 to 8; and (ii) from 1 to 99.999% by weight of a cosmetically acceptable vehicle for the inhibitor.
References Cited (Backward Citations)
US4139619A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-06-23 | 1995-12-23 | 1996-06-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-23 | 1999-12-23 | 2000-06-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-23 | 2003-12-23 | 2004-06-23 | $7700.00 | Window Closed / Lapsed |