Combination of derivatives of pyrimidine and of nonsteroid antiinflammatory agents for inducing and stimulating the growth of hair and reducing its loss

Claim 1

A combination of components that is effective for use in inducing and stimulating hair growth and for decreasing hair loss or for improving the appearance of the hair, said combination comprising: (a) a first component (A), comprising a physiologically acceptable medium and an effective amount of least one nonsteroid anti-inflammatory agent selected from the group consisting of the oxicams, niflumic acid, diclofenac, diflunisal, flufenamic acid, bufexamac, fenbufen, fenoprofen and physiologically acceptable salts or esters of the oxicams, niflumic acid, diclofenac, diflunisal, flufenamic acid, bufexamac, fenbufen, or fenoprofen; and (b) a second component (B), comprising a physiologically acceptable medium and an effective amount of at least one pyrimidine derivative having the formula: ##STR4## as well as acid addition salts thereof, wherein R 1 represents a group having the formula: ##STR5## wherein R 3 and R 4 are selected from the group consisting of hydrogen, lower alkyl, alkenyl, alkylaryl and cycloalkyl, the alkyl part of which is a lower alkyl radical, or R 3 and R 4 , with the nitrogen to which they are each bound, form a heterocyclic group, which is unsubstituted or is substituted on the carbon atoms with one to three lower alkyl, hydroxy, or alkoxy, and which is selected from the group consisting of aziridinyl, azetidinyl, pyrrolidinyl, piperidino, hexahydrolazepinyl, heptamethylenimino, octamethyleneimino, morpholino and 4-(lower alkyl)piperazinyl, and wherein R 2 is selected from the group consisting of hydrogen, lower alkyl, alkenyl, alkoxyalkyl, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl and haloarylalkyl, the alkyl part of which is a lower alkyl radical, wherein said components are used as separate components that are used either successively or intermittently or are mixed immediately prior to use for use as a composition containing said components and wherein said effective amount of each component is effective, when used as a combination, to induce and stimulate hair growth and reduce its loss.