US4596812A
Expired / Lapsed
US
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Methods and solutions for treating male pattern alopecia
Assignee: Pharmacia and Upjohn Co
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Filing: 1980-08-28
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Granted: 1986-06-24
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Expires: 2000-08-28
Abstract
Abstract This invention relates to the method for treating the form of alopecia commonly known as "male pattern baldness" which comprises regular topical application to the affected areas of the human scalp of a composition containing as at least one of its active ingredients 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine. It also encompasses the aforesaid compound itself for use as a therapeutic agent to arrest and reverse male pattern alopecia.
Inventors
- 👤 Charles A. Chidsey, III
- 👤 Guinter Kahn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:56
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/494; A61K8/4953; A61Q; A61Q7/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
26 words
A method of treating humans for alopecia which comprises topically applying to the human scalp an effective amount of a solution containing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine and a solvent.
Claim 2
Independent Claim
26 words
A method of treating humans for alopecia which comprises topically applying to the human scalp an effective amount of a solution containing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine and a solvent.
Claim 3
Dependent Claim
17 words
The method as defined in claim 1 wherein the said solution comprises 1% of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine in dimethylacetamide.
Claim 4
Dependent Claim
22 words
The method as defined in claim 1 wherein said solution comprises 1% of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine in equal parts of dimethylacetamide and ethyl alcohol.
Claim 5
Dependent Claim
23 words
The method as defined in claim 1 wherein said solution comprises 1/2% of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine in equal parts of ethyl alcohol and propylene glycol.
Claim 6
Dependent Claim
23 words
The method as defined in claim 1 wherein said solution comprises 1% of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine in equal parts of ethyl alcohol and propylene glycol.
Claim 7
Dependent Claim
25 words
The method as defined in claim 1 and wherein said solution comprises 2% of said 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine in equal parts of ethyl alcohol and propylene glycol.
Claim 8
Dependent Claim
24 words
The method as defined in claim 1 and wherein said solvent is selected from the group consisting of dimethylacetamide, ethyl alcohol and propylene glycol.
Claim 9
Dependent Claim
17 words
The method as defined in claim 1 and wherein the concentration of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine is 1/2% to 5%.
Claim 10
Independent Claim
30 words
The method of arresting and reversing male pattern alopecia which comprises continued periodical topical application to the human scalp of a physiologically effective dose of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine dissolved in a solvent.
Claim 11
Independent Claim
30 words
The method of arresting and reversing male pattern alopecia which comprises continued periodical topical application to the human scalp of a physiologically effective dose of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine dissolved in a solvent.
Claim 12
Dependent Claim
23 words
The method as defined in claim 9 wherein said solvent is selected from the group consisting of ethyl alcohol, propylene glycol and dimethylacetamide.
Claim 13
Dependent Claim
20 words
The method of claim 9 wherein the 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine is present in the solution in an amount of 0.5% to 2.0%.
Claim 14
Dependent Claim
38 words
The invention of any one of claims 1-11 and wherein the method further comprises occlusion of the effective amount of the solution after application to the human scalp for a period of time sufficient to effect hair growth.
Claim 15
Dependent Claim
47 words
In a pharmaceutical composition containing minoxidil in solution, the improvement characterized by: a vehicle which adapts said composition for topical application to the human scalp for the treatment of alopecia, said minoxidil being dissolved in said composition in a concentration of from about 0.5% to about 5.0%.
Claim 16
Dependent Claim
47 words
In a pharmaceutical composition containing minoxidil in solution, the improvement characterized by: a vehicle which adapts said composition for topical application to the human scalp for the treatment of alopecia, said minoxidil being dissolved in said composition in a concentration of from about 0.5% to about 5.0%.
Claim 17
Dependent Claim
38 words
A topical pharmaceutical solution for the treatment of alopecia consisting essentially of: (a) from about 0.5% to about 5.0% minoxidil of said solution, and (b) a vehicle which adapts said solution for topical application to the human scalp.
Claim 18
Dependent Claim
38 words
A topical pharmaceutical solution for the treatment of alopecia consisting essentially of: (a) from about 0.5% to about 5.0% minoxidil of said solution, and (b) a vehicle which adapts said solution for topical application to the human scalp.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |