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US5730714A
Expired / Lapsed
US
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Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose
Assignee: University of California
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Filing: 1994-09-26
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Granted: 1998-03-24
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Expires: 2014-09-26
Abstract
Abstract The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
Inventors
- 👤 Richard Guy
- 👤 Girish Rao
- 👤 Peretz Glikfeld
- 👤 Christopher Cullander
- 👤 Robert S. Hinz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:24
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/41; A61B5/411; A61B5/145; A61B5/14532; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61M; A61M37/00; A61M2037/0007
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
142 words
An iontophoretic method for the substantially continuously in vivo monitoring of blood glucose in a mammal, the method comprising the steps of: (a) placing a device comprised of a first electrically conducting means, a second electrically conducting means, and at least one collection reservoir on the skin or mucous membrane of the mammal to be monitored, wherein said second electrically conducting means is physically and electrically separated from said first electrically conducting means, (b) connecting said device to an electrical source to create an electrical circuit, (c) continuously applying a constant current in said electrical circuit to cause said blood glucose to migrate into said collection reservoir, and (d) collecting and monitoring the glucose in said collection reservoir, with the proviso that the contact of the device on the skin or mucous membrane and the collection occurs at physiologically acceptable pH conditions.
Claim 2
Dependent Claim
142 words
An iontophoretic method for the substantially continuously in vivo monitoring of blood glucose in a mammal, the method comprising the steps of: (a) placing a device comprised of a first electrically conducting means, a second electrically conducting means, and at least one collection reservoir on the skin or mucous membrane of the mammal to be monitored, wherein said second electrically conducting means is physically and electrically separated from said first electrically conducting means, (b) connecting said device to an electrical source to create an electrical circuit, (c) continuously applying a constant current in said electrical circuit to cause said blood glucose to migrate into said collection reservoir, and (d) collecting and monitoring the glucose in said collection reservoir, with the proviso that the contact of the device on the skin or mucous membrane and the collection occurs at physiologically acceptable pH conditions.
Claim 3
Dependent Claim
19 words
The method of claim 1 additionally comprising the step of correlating the collected glucose to a glucose blood concentration.
Claim 4
Dependent Claim
54 words
The method of claim 1 wherein step (d) is accomplished using at least one analyzing device selected from the group consisting of a glucose or glucose metabolite biosensor, a glucose or glucose metabolite selective electrode, and a glucose or glucose metabolite specific colorimetric reagent, wherein said analyzing device is located in said collection reservoir.
Claim 5
Dependent Claim
33 words
The method of claim 3 wherein said analyzing device is linked to a glucose delivery device and the method further includes step (e) delivery of glucose to the mammal in need of glucose.
Claim 6
Dependent Claim
26 words
The method of claim 3 wherein said analyzing device is linked to an alarm system to alert an operator that the monitored mammal requires additional glucose.
Claim 7
Independent Claim
68 words
A method of monitoring glucose transferred from a source within mammalian tissue, the method comprising the following steps: placing a glucose collector against the mammalian tissue surface; substantially continuously transferring glucose from the source into the glucose collector; and monitoring the glucose within the glucose collector, with the proviso that contact of the glucose collector with the tissue surface and the collection occur under physiologically acceptable pH conditions.
Claim 8
Independent Claim
68 words
A method of monitoring glucose transferred from a source within mammalian tissue, the method comprising the following steps: placing a glucose collector against the mammalian tissue surface; substantially continuously transferring glucose from the source into the glucose collector; and monitoring the glucose within the glucose collector, with the proviso that contact of the glucose collector with the tissue surface and the collection occur under physiologically acceptable pH conditions.
Claim 9
Dependent Claim
12 words
The method of claim 6 wherein the glucose collector uses a reservoir.
Claim 10
Dependent Claim
12 words
The method of claim 6 wherein the mammalian tissue is human skin.
Claim 11
Dependent Claim
12 words
The method of claim 8 wherein the method is performed in vivo.
Claim 12
Dependent Claim
11 words
The method of claim 6 wherein the transferring step uses iontophoresis.
Claim 13
Dependent Claim
19 words
The method of claim 10 further comprising the step of first placing an electrode against the mammalian tissue surface.
Claim 14
Dependent Claim
12 words
The method of claim 10 wherein the mammalian tissue is human skin.
Claim 15
Dependent Claim
12 words
The method of claim 12 wherein the method is performed in vivo.
Claim 16
Dependent Claim
19 words
The method of claim 6 wherein the monitoring step comprises measuring the concentration of glucose within the glucose collector.
Claim 17
Independent Claim
74 words
A method of monitoring glucose metabolite transferred from a source across mammalian tissue, the method comprising the following steps: placing a glucose metabolite collector against a tissue surface; substantially continuously transferring glucose metabolite from the source into the glucose metabolite collector; and monitoring the glucose metabolite within the glucose metabolite collector, with the proviso that contact of the glucose metabolite collector with the tissue surface and the collection occur under physiologically acceptable pH conditions.
Claim 18
Independent Claim
74 words
A method of monitoring glucose metabolite transferred from a source across mammalian tissue, the method comprising the following steps: placing a glucose metabolite collector against a tissue surface; substantially continuously transferring glucose metabolite from the source into the glucose metabolite collector; and monitoring the glucose metabolite within the glucose metabolite collector, with the proviso that contact of the glucose metabolite collector with the tissue surface and the collection occur under physiologically acceptable pH conditions.
Claim 19
Dependent Claim
13 words
The method of claim 15 wherein the glucose metabolite collector comprises a reservoir.
Claim 20
Dependent Claim
12 words
The method of claim 15 wherein the mammalian tissue is human skin.
Claim 21
Dependent Claim
12 words
The method of claim 17 wherein the method is performed in vivo.
Claim 22
Dependent Claim
11 words
The method of claim 15 wherein the transferring step uses iontophoresis.
Claim 23
Dependent Claim
19 words
The method of claim 19 further comprising the step of first placing an electrode against the mammalian tissue surface.
Claim 24
Dependent Claim
12 words
The method of claim 19 wherein the mammalian tissue is human skin.
Claim 25
Dependent Claim
12 words
The method of claim 21 wherein the method is performed in vivo.
Claim 26
Dependent Claim
21 words
The method of claim 15 wherein the monitoring step includes measuring the concentration of glucose metabolite within the glucose metabolite collector.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-03-23 | 2001-09-22 | 2002-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-23 | 2005-09-22 | 2006-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-23 | 2009-09-22 | 2010-03-24 | $7700.00 | Window Closed / Lapsed |