US4767401A
Expired / Lapsed
US
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Iontophoretic administration of ionizable or polar medicaments to a mammalian body
Assignee: Individual
•
Filing: 1982-08-26
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Granted: 1988-08-30
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Expires: 2002-08-26
Abstract
Abstract A method for the iontophoretic administration of topical or systemic ionizable or polar medicaments to a mammalian body, and articles adapted therefor, are disclosed.
Inventors
- 👤 Maurice Seiderman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:26
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61F; A61F13/00; A61F13/00051; A61F13/00063; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61F2013/00089; A61F2013/00157; A61F2013/00217; A61F2013/00221; A61F2013/00361; A61F2013/00365; A61F2013/00519; A61F2013/00902; A61F2013/00927; A61F2013/00936; A61N1/0432; A61N1/0436
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
111 words
A bandage for iontophoretically administering a topical or systemic ionizable or polar medicament to a mammalian body having a wound, lesion, or the like thereon, comprising: (a) a substrate (b) an ionizable or polar medicament borne on said substrate, which medicament is responsive, in terms of migration to an electric field; and (c) a single electrode of an electrochemically-active material in electrically cooperative relationship with said medicament, for generating an iontophoretically effective, localized electric current between said medicament and the mammalian body to which the bandage is applied, to thereby cause the medicament to migrate deeply within said wound, lesion, or the like upon activation of the bandage by electrolytic fluids.
Claim 2
Dependent Claim
111 words
A bandage for iontophoretically administering a topical or systemic ionizable or polar medicament to a mammalian body having a wound, lesion, or the like thereon, comprising: (a) a substrate (b) an ionizable or polar medicament borne on said substrate, which medicament is responsive, in terms of migration to an electric field; and (c) a single electrode of an electrochemically-active material in electrically cooperative relationship with said medicament, for generating an iontophoretically effective, localized electric current between said medicament and the mammalian body to which the bandage is applied, to thereby cause the medicament to migrate deeply within said wound, lesion, or the like upon activation of the bandage by electrolytic fluids.
Claim 3
Dependent Claim
76 words
The bandage of claim 1, wherein said substrate defines a medial portion bounded by terminal portions, said electrode borne upon said substrate within said medial portion and supporting a discrete quantity of said medicament within its peripheral dimensions, said electrode presenting sufficient surface area for contact with said body to establish an iontophoretically-effective electric current between said medicament and said body to cause migration of said medicament deeply within said wound, lesion, or the like thereon.
Claim 4
Dependent Claim
50 words
The bandage of claim 1, wherein said substrate defines a medial portion bounded by terminal portions, said medicament borne upon said substrate within said medial portion, said electrode being confined to at least one of said terminal portions and partially overlapping said medial portion in electrically-cooperative relationship with said medicament.
Claim 5
Dependent Claim
33 words
The bandage of claim 1, wherein said medicament is absorbed within a carrier selected from the group consisting of sterile paper, sterile cloth, and hydrogel polymers, said carrier being adhered to said bandage.
Claim 6
Dependent Claim
12 words
The bandage of claim 1, wherein said medicament is a proteinaceous medicament.
Claim 7
Dependent Claim
15 words
The bandage of claim 5, wherein said proteinaceous medicament is comprised of an undenatured protein.
Claim 8
Dependent Claim
15 words
The bandage of claim 5, wherein said proteinaceous medicament is comprised of a denatured protein.
Claim 9
Dependent Claim
15 words
The bandage of claim 7, wherein said proteinaceous medicament further comprises a bio-compatible metallic medicament.
Claim 10
Dependent Claim
10 words
The bandage of claim 8, wherein the metal is silver.
Claim 11
Dependent Claim
11 words
The bandage of claim 5, wherein said medicament is silver protein.
Claim 12
Dependent Claim
11 words
The bandage of claim 10, wherein said electrode is aluminum metal.
Claim 13
Dependent Claim
18 words
The bandage of claim 11, wherein said aluminum is applied as either a foil or as a paint.
Claim 14
Independent Claim
107 words
A method for iontophoretically administering a topical or systemic ionizable or polar medicament to a mammalian body having a wound, lesion, or the like thereon, whereby said medicament is responsive, in terms of migration, to an electric field, comprising the step of generating an electric field by voltaic interaction between a single electrode of electrochemically-active material borne upon a bandage substrate and in electrically-cooperative relationship with said medicament, and said body when said bandage substrate is placed over said wound, lesion, or the like, upon activation of the bandage by electrolytic fluids, whereby the medicament is caused to migrate deeply within said wound, lesion, or the like.
Claim 15
Independent Claim
107 words
A method for iontophoretically administering a topical or systemic ionizable or polar medicament to a mammalian body having a wound, lesion, or the like thereon, whereby said medicament is responsive, in terms of migration, to an electric field, comprising the step of generating an electric field by voltaic interaction between a single electrode of electrochemically-active material borne upon a bandage substrate and in electrically-cooperative relationship with said medicament, and said body when said bandage substrate is placed over said wound, lesion, or the like, upon activation of the bandage by electrolytic fluids, whereby the medicament is caused to migrate deeply within said wound, lesion, or the like.
Claim 16
Dependent Claim
12 words
The method of claim 13, wherein said medicament is a proteinaceous medicament.
Claim 17
Dependent Claim
15 words
The method of claim 14, wherein said proteinaceous medicament is comprised of an undenatured protein.
Claim 18
Dependent Claim
15 words
The method of claim 14, wherein said proteinaceous medicament is comprised of a denatured protein.
Claim 19
Dependent Claim
15 words
The method of claim 16, wherein said proteinaceous medicament further comprises a bio-compatible metallic medicament.
Claim 20
Dependent Claim
10 words
The method of claim 17, wherein the metal is silver.
Claim 21
Dependent Claim
31 words
The method of claim 14, wherein said medicament is silver protein and said electrode is a metal foil capable of establishing a net positive electric charge with respect to said body.
Claim 22
Dependent Claim
37 words
The method of iontophoretically adminstering an ionizable or polar medicament as defined by claim 13, wherein said medicament is in a dry state, said method further comprising the step of hydrating said medicament with an electrolyte fluid.
Claim 23
Dependent Claim
24 words
The method of claim 20, wherein said electrolyte fluid is either the fluid within the wound, lesion, or the like or is isotonic saline.
Claim 24
Dependent Claim
11 words
The method of claim 20, wherein said electrode is aluminum foil.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-30 | 1992-02-29 | 1992-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-30 | 1996-02-29 | 1996-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-30 | 2000-02-29 | 2000-08-30 | $7700.00 | Window Closed / Lapsed |