Patent US5686287A successfully refreshed from Google Patents.
US5686287A
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Marek's disease virus vaccine
Assignee: Akzo Nobel NV
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Filing: 1995-07-14
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Granted: 1997-11-11
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Expires: 2015-07-14
Abstract
Abstract The present invention is concerned with a new strain of Mareks Disease Virus and to a vaccine for the protection of poultry against Mareks Disease containing the novel strain. The invention also relates to bivalent or polyvalent vaccines comprising in addition other viruses of the Mareks Disease virus group, i.e. HVT.
Inventors
- 👤 William Baxendale
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:13
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K39/00; A61K39/12; A61K39/245; A61K39/255; A61P; A61P31/00; A61P31/12; A61K2039/70; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16311; C12N2710/16334; Y; Y10; Y10S; Y10S530/00; Y10S530/82; Y10S530/826
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
34 words
An attenuated strain of Marek's Disease Virus serotype I which, when liberated from infected cells by sonication, results in at most a 100-fold decrease in cell-free virus titre compared with the cell-associated virus titre.
Claim 2
Dependent Claim
34 words
An attenuated strain of Marek's Disease Virus serotype I which, when liberated from infected cells by sonication, results in at most a 100-fold decrease in cell-free virus titre compared with the cell-associated virus titre.
Claim 3
Dependent Claim
19 words
An attenuated strain according to claim 1 which results in at most a 50-fold decrease in cell-free virus titre.
Claim 4
Dependent Claim
19 words
An attenuated strain according to claim 1 which results in at most a 10-fold decrease in cell-free virus titre.
Claim 5
Dependent Claim
10 words
An attenuated strain according to claim 1 in cell-associated form.
Claim 6
Dependent Claim
33 words
An attenuated strain according to claim 4, which is the strain of Marek's Disease Virus serotype I deposited at the European Collection of Animal Cell Cultures, Porton Down, UK under accession No. V94062211.
Claim 7
Dependent Claim
10 words
An attenuated strain according to claim 1 in cell-free form.
Claim 8
Dependent Claim
28 words
An attenuated cell-free strain of Marek's Disease Virus serotype I which is deposited at the European Collection of Animal Cell Cultures, Porton Down, UK under accession No. V94062211.
Claim 9
Dependent Claim
28 words
An attenuated cell-free strain of Marek's Disease Virus serotype I which is deposited at the European Collection of Animal Cell Cultures, Porton Down, UK under accession No. V94062211.
Claim 10
Dependent Claim
29 words
A vaccine for use in the protection of poultry against Marek's Disease comprising the attenuated Marek's Disease Virus serotype I according to claim 1 and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
10 words
A vaccine according to claim 8, further comprising cell-free HVT.
Claim 12
Dependent Claim
12 words
A vaccine according to claim 8, further comprising cell-free MDV serotype II.
Claim 13
Dependent Claim
14 words
A vaccine according to claim 8, further comprising antigens derived from other poultry pathogens.
Claim 14
Dependent Claim
11 words
A vaccine according to claim 8, wherein the vaccine is lyophilized.
Claim 15
Independent Claim
94 words
A method for the preparation of a vaccine that protects poultry against Marek's Disease which comprises: (a) growing a serotype I Marek's Disease virus in cell culture from which sufficient quantities of cell-free virus necessary to prepare an effective immunizing dosage can be obtained, (b) disrupting the cells, (c) subsequently collecting the cell-free viruses, and (d) subjecting the material obtained from step (c) to at least one of the following treatments: i clarifying by centrifugation and/or filtration; ii adding buffer; iii adding a stabilizing agent; iv putting the material in a vial; v freeze-drying.
Claim 16
Independent Claim
94 words
A method for the preparation of a vaccine that protects poultry against Marek's Disease which comprises: (a) growing a serotype I Marek's Disease virus in cell culture from which sufficient quantities of cell-free virus necessary to prepare an effective immunizing dosage can be obtained, (b) disrupting the cells, (c) subsequently collecting the cell-free viruses, and (d) subjecting the material obtained from step (c) to at least one of the following treatments: i clarifying by centrifugation and/or filtration; ii adding buffer; iii adding a stabilizing agent; iv putting the material in a vial; v freeze-drying.
Claim 17
Dependent Claim
19 words
A method of controlling Marek's Disease in poultry comprising administering to the poultry the vaccine according to claim 8.
Claim 18
Dependent Claim
12 words
A vaccine according to claim 9, further comprising cell-free MDV serotype II.
Claim 19
Dependent Claim
14 words
A vaccine according to claim 9, further comprising antigens derived from other poultry pathogens.
Claim 20
Dependent Claim
14 words
A vaccine according to claim 10, further comprising antigens derived from other poultry pathogens.
Claim 21
Dependent Claim
14 words
A vaccine according to claim 15, further comprising antigens derived from other poultry pathogens.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-11-10 | 2001-05-12 | 2001-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-11-10 | 2005-05-12 | 2005-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-11-10 | 2009-05-12 | 2009-11-11 | $7700.00 | Window Closed / Lapsed |