EP0496135A2
Expired / Lapsed
EP
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Cell free marek's disease virus vaccine
Assignee: Intervet International BV
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Filing: 1991-12-20
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Granted: —
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Expires: 2011-12-20
Abstract
Abstract The present invention is concerned with a vaccine for the protection of poultry against Marek's Disease. The cell free vaccine of the invention facilitates the handling of the vaccine and reduces the chance of physical abuse. The invention also relates to bivalent or polyvalent vaccines comprising in addition other viruses of the Marek's Disease virus group, i.e. HVT.
Inventors
- 👤 William Baxendale
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 11:13
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K39/00; A61K39/12; A61K39/245; A61K39/255; A61P; A61P31/00; A61P31/12; A61P31/20; A61P31/22; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16311; C12N2710/16334; C12N2710/16361; C12N2710/16364
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
26 words
A vaccine for the protection of poultry against Marek's Disease, characterized in that it comprises cell-free Marek's Disease serotype 2 viruses, and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
14 words
A vaccine according to claim 1, characterized in that it comprises cell-free SB-1 viruses.
Claim 3
Dependent Claim
14 words
A vaccine according to claim 1, characterized in that it comprises cell-free B-24 viruses.
Claim 4
Dependent Claim
24 words
A vaccine according to claim 1, characterized in that the dosage of the cell-free Marek's Disease serotype 2 virus is at least 2,2 pfu/chick.
Claim 5
Dependent Claim
16 words
A vaccine according to claim 4, characterized in that said dosage is at least 2,7 pfu/chick.
Claim 6
Dependent Claim
16 words
A vaccine according to claim 5, characterized in that said dosage is at least 3,2 pfu/chick.
Claim 7
Dependent Claim
14 words
A vaccine according to claim 1-6, characterized in that it also comprises cell-free HVT.
Claim 8
Dependent Claim
12 words
A vaccine according to claims 1-7, characterized in that it is lyophilized.
Claim 9
Independent Claim
94 words
A method for the preparation of a vaccine that protects poultry against Marek's Disease which comprises: a growing a serotype 2 Marek's Disease virus in a cell culture from which sufficient quantities cell-free virus necessary to prepare an effective immunizing dosage can be obtained, b disrupting the cells, c subsequently collecting the cell-free viruses, and d subjecting the material obtained from step c. to at least one of the following treatments: i clarifying by centrifugation and/or filtration; ii adding buffer; iii adding a stabilizing agent; iv putting the material in a vial; v freeze-drying.
Claim 10
Dependent Claim
23 words
A method according to claim 9, characterized in that the titre of cell-free virus after step b is at least 4 logs pfu/ml.
Claim 11
Independent Claim
19 words
A method of controlling Marek's Disease in poultry comprising administering the vaccine according to claims 1-7 to the birds.
References Cited (Backward Citations)
No citation records indexed.
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