Patent US5656016A successfully refreshed from Google Patents.
US5656016A
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Sonophoretic drug delivery system
Assignee: Hospira Inc
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Filing: 1996-03-18
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Granted: 1997-08-12
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Expires: 2016-03-18
Abstract
Abstract The present invention relates to devices and methods for enhancing the rate and efficacy of permeation of a drug into and through skin and into the circulatory system utilizing ultrasound.
Inventors
- 👤 John E. Ogden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:10
CPC Classifications
A; A61; A61M; A61M37/00; A61M37/0092
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
130 words
A sonophoretic drug delivery system for delivering an agent or a drug to an animal comprising: a generator constructed to generate an electrical signal at a predetermined frequency, a cable having a first end portion connected to said generator and having a second end portion, a transducer connected to said second end portion of said cable, said transducer constructed to convert said electrical signal into mechanical energy, said transducer being a wide-band transducer, a transmission line having a proximal end portion and a distal end portion, said proximal end portion connected to said transducer, said transmission line constructed to transmit mechanical energy therethrough, said distal end portion of said transmission line constructed to deliver mechanical energy to a drug delivery site, and a control system for adjusting said electrical signal.
Claim 2
Dependent Claim
130 words
A sonophoretic drug delivery system for delivering an agent or a drug to an animal comprising: a generator constructed to generate an electrical signal at a predetermined frequency, a cable having a first end portion connected to said generator and having a second end portion, a transducer connected to said second end portion of said cable, said transducer constructed to convert said electrical signal into mechanical energy, said transducer being a wide-band transducer, a transmission line having a proximal end portion and a distal end portion, said proximal end portion connected to said transducer, said transmission line constructed to transmit mechanical energy therethrough, said distal end portion of said transmission line constructed to deliver mechanical energy to a drug delivery site, and a control system for adjusting said electrical signal.
Claim 3
Dependent Claim
21 words
A sonophoretic drug delivery system of claim 1 wherein said frequency is from about 20 KiloHertz to about 300 MegaHertz range.
Claim 4
Dependent Claim
21 words
A sonophoretic drug delivery system of claim 1 wherein said frequency is from about 1 MegaHertz to about 300 MegaHertz range.
Claim 5
Dependent Claim
21 words
A sonophoretic drug delivery system of claim 1 wherein said frequency is from about 10 MegaHertz to about 300 MegaHertz range.
Claim 6
Dependent Claim
24 words
A sonophoretic drug delivery system of claim 1 further comprising an amplifier constructed to boost said frequency of said electrical signal from said generator.
Claim 7
Independent Claim
181 words
A method for delivering an agent transdermally comprising the steps of: providing a drug delivery system, said system comprising a generator constructed to generate an electrical signal at a predetermined frequency, a cable having a first end portion connected to said generator and having a second end portion, a transducer connected to said second end portion of said cable, said transducer constructed to convert said electrical signal into mechanical energy, a transmission line having a proximal end portion and a distal end portion, said proximal end portion connected to said transducer, said transmission line constructed to transmit mechanical energy therethrough, said distal end portion of said transmission line constructed to deliver mechanical energy to a drug delivery site spaced from said transducer, and a control system for adjusting said electrical signal; providing an agent for transdermal delivery; placing said agent in contact with a drug delivery site on an animal; placing said distal end portion of said transmission line in contact with said agent; and activating said drug delivery system, whereby said agent is transdermally delivered at said drug delivery site.
Claim 8
Independent Claim
181 words
A method for delivering an agent transdermally comprising the steps of: providing a drug delivery system, said system comprising a generator constructed to generate an electrical signal at a predetermined frequency, a cable having a first end portion connected to said generator and having a second end portion, a transducer connected to said second end portion of said cable, said transducer constructed to convert said electrical signal into mechanical energy, a transmission line having a proximal end portion and a distal end portion, said proximal end portion connected to said transducer, said transmission line constructed to transmit mechanical energy therethrough, said distal end portion of said transmission line constructed to deliver mechanical energy to a drug delivery site spaced from said transducer, and a control system for adjusting said electrical signal; providing an agent for transdermal delivery; placing said agent in contact with a drug delivery site on an animal; placing said distal end portion of said transmission line in contact with said agent; and activating said drug delivery system, whereby said agent is transdermally delivered at said drug delivery site.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-11 | 2001-02-10 | 2001-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-11 | 2005-02-10 | 2005-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-11 | 2009-02-10 | 2009-08-12 | $7700.00 | Window Closed / Lapsed |