Patent US2115788A successfully refreshed from Google Patents.
US5474531A
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Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis
Assignee: Coraje Inc
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Filing: 1994-11-01
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Granted: 1995-12-12
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Expires: 2014-11-01
Abstract
Abstract Ultrasonic apparatus and method for coupling ultrasonic energy into intravascular walls to enhance phonophoresis and for dissolution of intravascular blockages. The apparatus includes a radiator for coupling ultrasonic waves and a piezoelectric crystal, connected with said radiator, for the intravascular generation of ultrasonic waves; said ultrasonic waves being propagated along a longitudinal axis of said piezoelectric crystal. The radiator is sized for intravascular insertion. A transmission cable may be provided for transmitting ultrasonic waves from an ultrasonic transducer to the radiator. A seed liquid is introduced proximate the radiator for promoting cavitation of intravascular fluid. In addition, enhancement of dissolution of intravascular blockages and inhibition of restenosis by chemical agents is significantly increased when combined with ultrasonic energy.
Inventors
- 👤 Robert E. Carter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:42
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/22; A61B17/22004; A61B17/22012; A61B17/2202; A61M; A61M37/00; A61M37/0092; A61B2017/22001; A61B2017/22002; A61B2017/22005; A61B2017/22007; A61B2017/22008; A61B2017/22021; A61B2017/22082
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
100 words
Ultrasonic apparatus for coupling ultrasound into intravascular walls and fluid comprising: ultrasonic transducer means for generating ultrasonic waves; a catheter, comprising a distal end sized for intravascular insertion and a proximal end connected with the ultrasonic transducer; radiator means, disposed within said distal end of the catheter, for directing the ultrasonic waves into intravascular walls and fluid; transmission means, extending longitudinally through the catheter, for coupling said ultrasonic transducer to said radiator means; separate means for both promoting cavitation of the intravascular fluid proximate the radiator means and for introducing a physiologically active agent into the intravascular walls and fluid.
Claim 2
Dependent Claim
100 words
Ultrasonic apparatus for coupling ultrasound into intravascular walls and fluid comprising: ultrasonic transducer means for generating ultrasonic waves; a catheter, comprising a distal end sized for intravascular insertion and a proximal end connected with the ultrasonic transducer; radiator means, disposed within said distal end of the catheter, for directing the ultrasonic waves into intravascular walls and fluid; transmission means, extending longitudinally through the catheter, for coupling said ultrasonic transducer to said radiator means; separate means for both promoting cavitation of the intravascular fluid proximate the radiator means and for introducing a physiologically active agent into the intravascular walls and fluid.
Claim 3
Dependent Claim
35 words
The apparatus according to claim 1 wherein the means for both promoting cavitation and introducing a physiologically active agent comprises lumen means for introducing a seed fluid into the intravascular fluid proximate the radiator means.
Claim 4
Dependent Claim
29 words
The apparatus according to claim 2 wherein the lumen means comprises a tip, including at least one outlet aperture therein, for directing said seed fluid toward the intravascular walls.
Claim 5
Dependent Claim
25 words
The apparatus according to claim 3 wherein the tip includes a plurality of outlet apertures therein, for directing said seed fluid toward the intravascular walls.
Claim 6
Dependent Claim
26 words
The apparatus according to claim 1 wherein the physiologically active agent comprises a composition having clot dissolution activity and a composition having activity for inhibiting restenosis.
Claim 7
Dependent Claim
121 words
Ultrasonic apparatus for coupling ultrasound into intravascular walls and fluid comprising: a catheter, comprising a distal end and a proximal end; radiator means, disposed within the distal end of the catheter and sized for intravascular insertion, for directing ultrasonic waves into intravascular walls and fluid; means, connected with said radiator means, for generation of the ultrasonic waves; and separate means for both promoting cavitation of the intravascular fluid proximate the radiator means, and for introducing a physiologically active agent proximate the radiator means, said separate means comprising: lumen means for introducing a seed fluid into the intravascular fluid, wherein said lumen means comprises a tip, including at least one outlet aperture therein for directing the seed fluid toward the intravascular walls.
Claim 8
Dependent Claim
121 words
Ultrasonic apparatus for coupling ultrasound into intravascular walls and fluid comprising: a catheter, comprising a distal end and a proximal end; radiator means, disposed within the distal end of the catheter and sized for intravascular insertion, for directing ultrasonic waves into intravascular walls and fluid; means, connected with said radiator means, for generation of the ultrasonic waves; and separate means for both promoting cavitation of the intravascular fluid proximate the radiator means, and for introducing a physiologically active agent proximate the radiator means, said separate means comprising: lumen means for introducing a seed fluid into the intravascular fluid, wherein said lumen means comprises a tip, including at least one outlet aperture therein for directing the seed fluid toward the intravascular walls.
Claim 9
Dependent Claim
25 words
The apparatus according to claim 6 wherein the tip includes a plurality of outlet apertures therein for directing the seed fluid toward the intravascular walls.
Claim 10
Dependent Claim
23 words
The apparatus according to claim 6 wherein the seed fluid comprises an aqueous saline solution containing carbon dioxide and a physiologically active agent.
Claim 11
Dependent Claim
19 words
The apparatus according to claim 6 wherein the physiologically active agent comprises a composition having activity for inhibiting restenosis.
Claim 12
Dependent Claim
151 words
Ultrasonic apparatus for coupling ultrasound into intravascular walls and fluid comprising: a catheter, comprising a distal end and a proximal end; radiator means, disposed within the distal end of the catheter and sized for intravascular insertion, for directing ultrasonic waves into intravascular walls and fluid; ultrasonic transducer means, disposed exterior to the catheter and connected to the proximal end of the catheter for generating ultrasonic waves; transmission means, extending longitudinally through the catheter, for coupling the ultrasonic waves from the exterior ultrasonic transducer to the radiator means; and separate means for both promoting cavitation of the intravascular fluid proximate the radiator means, and for introducing a physiologically active agent proximate the radiator means, said separate means comprising: lumen means for introducing a seed fluid into the intravascular fluid, wherein said lumen means comprises a tip, including at least one outlet aperture therein for directing the seed fluid toward the intravascular walls.
Claim 13
Dependent Claim
151 words
Ultrasonic apparatus for coupling ultrasound into intravascular walls and fluid comprising: a catheter, comprising a distal end and a proximal end; radiator means, disposed within the distal end of the catheter and sized for intravascular insertion, for directing ultrasonic waves into intravascular walls and fluid; ultrasonic transducer means, disposed exterior to the catheter and connected to the proximal end of the catheter for generating ultrasonic waves; transmission means, extending longitudinally through the catheter, for coupling the ultrasonic waves from the exterior ultrasonic transducer to the radiator means; and separate means for both promoting cavitation of the intravascular fluid proximate the radiator means, and for introducing a physiologically active agent proximate the radiator means, said separate means comprising: lumen means for introducing a seed fluid into the intravascular fluid, wherein said lumen means comprises a tip, including at least one outlet aperture therein for directing the seed fluid toward the intravascular walls.
Claim 14
Independent Claim
104 words
A method for coupling ultrasound into intravascular walls and fluid, said method comprising the steps of: inserting a distal end of a catheter into a vessel having intravascular walls; generating ultrasonic waves from an ultrasonic transducer disposed exterior to said vessel; providing means for transmitting the ultrasonic waves to the distal end of the catheter; providing means for radiating the ultrasonic waves from the distal end of the catheter into a selected intravascular wall; providing means for promoting cavitation of the intravascular fluid proximate said selected intravascular wall; and introducing, into the intravascular fluid proximate said selected intravascular wall, a composition having physiological activity.
Claim 15
Independent Claim
104 words
A method for coupling ultrasound into intravascular walls and fluid, said method comprising the steps of: inserting a distal end of a catheter into a vessel having intravascular walls; generating ultrasonic waves from an ultrasonic transducer disposed exterior to said vessel; providing means for transmitting the ultrasonic waves to the distal end of the catheter; providing means for radiating the ultrasonic waves from the distal end of the catheter into a selected intravascular wall; providing means for promoting cavitation of the intravascular fluid proximate said selected intravascular wall; and introducing, into the intravascular fluid proximate said selected intravascular wall, a composition having physiological activity.
Claim 16
Dependent Claim
35 words
The method of claim 11 wherein the step of providing means for promoting cavitation, comprises providing a lumen tip, including at least one outlet aperture therein, for directing the composition toward said selected intravascular wall.
Claim 17
Independent Claim
24 words
The method according to claim 11wherein the step of promoting cavitation comprises introducing into the intravascular fluid proximate the intravascular wall, a seed fluid.
Claim 18
Dependent Claim
28 words
The method according to claim 11 wherein the step of promoting cavitation comprises introducing into the intravascular wall a fluid comprising an aqueous saline solution, containing carbon dioxide.
Claim 19
Dependent Claim
20 words
The method according to claim 11 wherein the step of introducing a composition comprises introducing an agent for inhibiting restenosis.
Claim 20
Dependent Claim
20 words
The method according to claim 11 wherein the step of introducing a composition comprises introducing an agent for clot dissolution.
Claim 21
Independent Claim
112 words
A method for coupling ultrasound into intravascular walls and fluid, said method comprising the steps of: inserting a distal end of a catheter into a vessel; providing an ultrasonic transducer for generating ultrasonic waves; providing means for coupling the ultrasonic waves to a proximal end of the catheter; providing means for radiating ultrasonic waves from the distal end of the catheter into fluid and intravascular walls; providing means for promoting cavitation of the fluid proximate the intravascular walls; introducing into the intravascular fluid a composition, having physiological activity, proximate the intravascular walls; and providing a lumen tip, including at least one outlet aperture therein for directing the composition toward the intravascular walls.
Claim 22
Independent Claim
112 words
A method for coupling ultrasound into intravascular walls and fluid, said method comprising the steps of: inserting a distal end of a catheter into a vessel; providing an ultrasonic transducer for generating ultrasonic waves; providing means for coupling the ultrasonic waves to a proximal end of the catheter; providing means for radiating ultrasonic waves from the distal end of the catheter into fluid and intravascular walls; providing means for promoting cavitation of the fluid proximate the intravascular walls; introducing into the intravascular fluid a composition, having physiological activity, proximate the intravascular walls; and providing a lumen tip, including at least one outlet aperture therein for directing the composition toward the intravascular walls.
Claim 23
Dependent Claim
16 words
The method of claim 17 wherein the lumen tip includes a plurality of outlet apertures therein.
Claim 24
Dependent Claim
28 words
The method according to claim 17 wherein the step of providing means for promoting cavitation comprises introducing a seed fluid into the intravascular fluid proximate the intravascular walls.
Claim 25
Dependent Claim
22 words
The method of claim 19 wherein the step of introducing a seed fluid comprises introducing an aqueous saline solution containing carbon dioxide.
Claim 26
Dependent Claim
19 words
The method of claim 17 wherein the step of introducing a composition comprises introducing an agent for inhibiting restenosis.
Claim 27
Dependent Claim
19 words
The method of claim 17 wherein the step of introducing a composition comprises introducing an agent for clot dissolution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-12-11 | 1999-06-12 | 1999-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-11 | 2003-06-12 | 2003-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-11 | 2007-06-12 | 2007-12-12 | $7700.00 | Window Closed / Lapsed |