Patent US5632776A successfully refreshed from Google Patents.
US5632776A
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US
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Implantation materials
Assignee: Toray Industries Inc
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Filing: 1994-08-15
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Granted: 1997-05-27
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Expires: 2014-08-15
Abstract
Abstract The present invention is implantation materials comprising an anti-thrombogenic material contained in the surface in contact with blood, of a porous substrate with its voids filled with denatured albumin or a biodegradable polyester. Since they are excellent in anti-thrombogenic property and allow the positive introduction of cells into the implantation materials, they can prevent thrombogenesis for long periods of time. Especially even if they are used as artificial small diameter blood vessels of less than 6 mm in inner diameter, they show excellent patency.
Inventors
- 👤 Hajimu Kurumatani
- 👤 Hiroshi Kataoka
- 👤 Kyoko Yamada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:19
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L27/00; A61L27/14; A61L27/18; A61L27/22; A61L27/227; A61L27/50; A61L27/507; A61L27/56; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/06; A61L31/14; A61L31/146
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
83 words
An anti-thrombogenic implantation material consisting essentially of a layer of a porous substrate made of individual fibers having voids filled with a biodegradable polymer and a layer of an anti-thrombogenic agent formed onto a surface portion formed by said substrate and said biodegradable polymer, wherein said porous substrate has a coefficient of water permeability of 500 to 5,000 ml/cm 2 /min. 120 mmHg and said biodegradable polymer has a degradation period that is shorter than that of said anti-thrombogenic agent of said layer.
Claim 2
Dependent Claim
83 words
An anti-thrombogenic implantation material consisting essentially of a layer of a porous substrate made of individual fibers having voids filled with a biodegradable polymer and a layer of an anti-thrombogenic agent formed onto a surface portion formed by said substrate and said biodegradable polymer, wherein said porous substrate has a coefficient of water permeability of 500 to 5,000 ml/cm 2 /min. 120 mmHg and said biodegradable polymer has a degradation period that is shorter than that of said anti-thrombogenic agent of said layer.
Claim 3
Dependent Claim
16 words
An anti-thrombogenic implantation material according to claim 1, wherein said biodegradable polymer is a biodegradable polyester.
Claim 4
Dependent Claim
34 words
An anti-thrombogenic implantation material according to claim 2, wherein the biodegradable polyester is selected from the group consisting of polylactic acid, polyglycolic acid, polyhydroxylactic acid, polycaprolactone, polyethylene adipate, polydioxanone and copolymers of the foregoing.
Claim 5
Dependent Claim
15 words
An anti-thrombogenic implantation material according to claim 1, wherein said biodegradable polymer is denatured albumin.
Claim 6
Dependent Claim
39 words
An anti-thrombogenic implantation material according to claim 4, wherein said denatured albumin is crosslinked by a treatment selected from the group consisting of heat treatment, chemical crosslinking agent and a combination of heat treatment and a chemical crosslinking agent.
Claim 7
Dependent Claim
37 words
An anti-thrombogenic implantation material according to claim 1, wherein an additive selected from the group consisting of a basic protein, a polypeptide and both of a basic protein and a polypeptide is added to the biodegradable polymer.
Claim 8
Dependent Claim
38 words
An anti-thrombogenic implantation material according to claim 1, wherein an additive selected from the group consisting of a basic protein, a polypeptide and both of a basic protein and a polypeptide is added to the anti-thrombogenic agent layer.
Claim 9
Dependent Claim
38 words
An anti-thrombogenic implanation material according to claim 1, wherein the degradation period of the biogradable polymer is 3 to 400 days when said material is a sheet 10 mm square×2 mm thick and implanted subcutaneously in a rat.
Claim 10
Dependent Claim
23 words
An anti-thrombogenic implantation material according to claim 1, wherein the porous substrate contains at least 40 wt % of 0.5 denier or less.
Claim 11
Dependent Claim
35 words
An anti-thrombogenic implantation material according to claim 1, wherein the anti-thrombogenic agent is selected from the group consisting of a water soluble high polymer, both of a water soluble high polymer and a blood coagulant.
Claim 12
Dependent Claim
15 words
An anti-thrombogenic implantation material according to claim 1, wherein the anti-thrombogenic agent is a glycosaminoglycan.
Claim 13
Dependent Claim
22 words
An anti-thrombogenic implantation material according to claim 1, comprising a structure selected from the group consisting of artificial blood vessels and patches.
Claim 14
Dependent Claim
48 words
The anti-thromogenic implantation material defined in claim 1 wherein said voids are filled to such an extent that said substrate does not allow permeation of blood and achieves a coefficient of water permeability after filling with said biodegradable polymer of 50 ml/cm 2 /min. 120 mmHg or less.
Claim 15
Dependent Claim
26 words
An anti-thrombogenic implanation material according to claim 1 wherein the porous substrate is formed by a method selected from the group consisting of weaving and knitting.
Claim 16
Dependent Claim
21 words
An anti-thrombogenic implantation material according to claim 1 wherein the porous substrate is formed into a non-woven fabric by processing filaments.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-05-26 | 2000-11-25 | 2001-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-05-26 | 2004-11-25 | 2005-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-05-26 | 2008-11-25 | 2009-05-27 | $7700.00 | Window Closed / Lapsed |