US5578079A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible, surface modified materials
Assignee: BIOTECHNOLOGY LLC
•
Filing: 1993-04-14
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Granted: 1996-11-26
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Expires: 2013-04-14
Abstract
Abstract A method of permanently modifying the surface of a substrate material so as to develop a microscopically smooth, biocompatible surface thereon comprises covalently grafting a biocompatible polymeric material to the surface of the substrate material by radio frequency plasma-induced grafting. The biocompatible polymeric material is preferably the same as the substrate material. In addition, a method of permanently modifying the surface of a substrate material comprises subjecting the substrate surface to radio frequency plasma sufficient to raise the temperature at the substrate material to just above the glass transition temperature (T g ) of the substrate material for a time sufficient to produce a microscopically smooth, biocompatible surface on the substrate material. Further, a prosthesis used in mammals, including an intraocular lens, comprises a polymeric material core and a biocompatible polymeric material covalently grafted to the polymer core by radio frequency plasma induction.
Inventors
- 👤 Ihab Kamel
- 👤 David B. Soll
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 02:22
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0076; A61L27/00; A61L27/14; A61L27/16; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16; A61F2/1613; A61L27/28; A61L27/34; A61L33/0088; A61L33/06; A61L33/08; B; B05; B05D; B05D1/00; B05D1/62; B05D3/00; B05D3/14; B05D3/141; B05D3/142; B05D3/144; B29; B29C; B29C59/00; B29C59/14; C; C08; C08J; C08J7/00; C08J7/12; C08J7/16; C08J7/18; C23; C23C; C23C8/00; C23C8/06; C23C8/36; A61F2/0077; A61F2002/009; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
84 words
A prosthesis for use in mammals comprising a polymeric substrate material having a permanently modified microscopically smooth, biocompatible surface thereon, produced by covalently grafting a polymeric biocompatible material to the surface of the substrate material by radio frequency plasma induction, the biocompatible polymeric material comprising substantially the same material as the polymeric substrate and being physically grafted by covalent bonds to the substrate material, and the modified microscopically smooth, biocompatible surface being substantially free of surface irregularities at a magnification of at least 3,000×.
Claim 2
Dependent Claim
84 words
A prosthesis for use in mammals comprising a polymeric substrate material having a permanently modified microscopically smooth, biocompatible surface thereon, produced by covalently grafting a polymeric biocompatible material to the surface of the substrate material by radio frequency plasma induction, the biocompatible polymeric material comprising substantially the same material as the polymeric substrate and being physically grafted by covalent bonds to the substrate material, and the modified microscopically smooth, biocompatible surface being substantially free of surface irregularities at a magnification of at least 3,000×.
Claim 3
Dependent Claim
36 words
The prosthesis according to claim 1, wherein the biocompatible polymeric material is selected from the group consisting of polyacrylic acid, silicone, polypropylene, polyester, polytetrafluoroethylene, polyethylene terephthalate, polyurethane, polymethylmethacrylate and polymers of ethylenediamine, diethylenetriamine, allylamine or hydroxyethylmethacrylate.
Claim 4
Dependent Claim
52 words
A prosthesis used in mammals having a permanently modified, microscopically smooth, biocompatible surface comprising: (a) a polymeric material core; and (b) a biocompatible polymeric material covalently grafted to the surface of the polymeric material core by radio frequency plasma induction, the biocompatible polymeric material comprising substantially the same material as the core.
Claim 5
Dependent Claim
52 words
A prosthesis used in mammals having a permanently modified, microscopically smooth, biocompatible surface comprising: (a) a polymeric material core; and (b) a biocompatible polymeric material covalently grafted to the surface of the polymeric material core by radio frequency plasma induction, the biocompatible polymeric material comprising substantially the same material as the core.
Claim 6
Dependent Claim
35 words
The prosthesis according to claim 3, wherein the polymeric material is selected from the group consisting of polyacrylic acid, silicone, polypropylene, polyester, polytetrafluoroethylene, polyethylene terephthalate, polyurethane, polymethylmethacrylate, and polymers of ethylenediamine, diethylenetriamine, allylamine or hydroxyethylmethacrylate.
Claim 7
Dependent Claim
49 words
An intraocular lens having a permanently modified, smooth, biocompatible surface, comprising a polymeric material lens body, and a biocompatible polymeric material, said biocompatible polymeric material being covalently grafted to the surface of the lens body by radio frequency plasma induction and comprising substantially the same material as the body.
Claim 8
Dependent Claim
49 words
An intraocular lens having a permanently modified, smooth, biocompatible surface, comprising a polymeric material lens body, and a biocompatible polymeric material, said biocompatible polymeric material being covalently grafted to the surface of the lens body by radio frequency plasma induction and comprising substantially the same material as the body.
Claim 9
Dependent Claim
37 words
The intraocular lens according to claim 5, wherein the biocompatible polymeric material is selected from the group consisting of polyacrylic acid, silicone, polypropylene, polyester, polytetrafluoroethylene, polyethylene terephthalate, polyurethane, polymethylmethacrylate and polymers of ethylenediamine, diethylenetriamine, allylamine or hydroxyethylmethacrylate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-11-26 | 2000-05-27 | 2000-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-26 | 2004-05-27 | 2004-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-26 | 2008-05-27 | 2008-11-26 | $7700.00 | Window Closed / Lapsed |