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US5489678A Expired / Lapsed US ⏱️ 0.0 years remaining

Photolabile nucleoside and peptide protecting groups

Assignee: Affymetrix Inc
•
Filing: 1995-02-16
•
Granted: 1996-02-06
•
Expires: 2015-02-16
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Abstract

Abstract A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Inventors

  • 👤 Stephen P. A. Fodor
  • 👤 Lubert Stryer
  • 👤 James L. Winkler
  • 👤 Christopher P. Holmes
  • 👤 Dennis W. Solas

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 16:36
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/645; G01N21/6452; B; B01; B01J; B01J19/00; B01J19/0046; B82; B82Y; B82Y10/00; B82Y30/00; C; C07; C07C; C07C229/00; C07C229/02; C07C229/04; C07C229/06; C07C229/10; C07C229/14; C07C229/16; C07D; C07D263/00; C07D263/02; C07D263/30; C07D263/34; C07D263/44; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/62; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/073; C07H19/16; C07H19/173; C07H21/00; C07H21/04; C07K; C07K1/00; C07K1/04; C07K1/042; C07K1/045; C07K1/047; C07K1/06; C07K1/061; C07K1/062; C07K17/00; C07K17/02; C07K17/06; C07K17/14; C07K7/00; C07K7/04; C07K7/06; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6809; C12Q1/6813; C12Q1/6816; C12Q1/6834; C12Q1/6837; C12Q1/6869; C12Q1/6874; C40; C40B; C40B80/00; G01N21/17; G01N21/25; G01N21/251; G01N21/253; G01N21/6428; G03; G03F; G03F7/00; G03F7/004; G03F7/0045; G03F7/26; G03F7/265; G03F7/38; G11; G11C; G11C13/00; G11C13/0002; G11C13/0009; G11C13/0014; G11C13/0019; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00279; B01J2219/00306; B01J2219/00313; B01J2219/00315; B01J2219/00351; B01J2219/00427; B01J2219/00432; B01J2219/00434; B01J2219/00436; B01J2219/00457; B01J2219/00459; B01J2219/00468; B01J2219/00475; B01J2219/00497; B01J2219/005; B01J2219/00527; B01J2219/00529; B01J2219/00531; B01J2219/00583; B01J2219/00585; B01J2219/0059; B01J2219/00596; B01J2219/00603; B01J2219/00605; B01J2219/00608; B01J2219/00612; B01J2219/00614; B01J2219/00617; B01J2219/00623; B01J2219/00626; B01J2219/00632; B01J2219/00637; B01J2219/00646; B01J2219/00648; B01J2219/00659; B01J2219/0068; B01J2219/00686; B01J2219/00689; B01J2219/00695; B01J2219/00709; B01J2219/00711; B01J2219/00718; B01J2219/0072; B01J2219/00722; B01J2219/00725; C07B; C07B2200/00; C07B2200/11; C40B40/00; C40B40/04; C40B40/06; C40B40/10; C40B60/00; C40B60/14; G01N15/00; G01N15/10; G01N15/14; G01N15/1429; G01N15/1433; G01N21/6456; G01N21/6458; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S435/00; Y10S435/969; Y10S435/973; Y10S436/00; Y10S436/807; Y10S436/809

Claims Analysis

Total Claims: 36
Claim 1
Independent Claim 23 words
A compound comprising the following structure: ##STR25## wherein Y is the C-5' oxygen group of a deoxyribonucleic acid; and R 3 is alkyl.
Claim 2
Dependent Claim 23 words
A compound comprising the following structure: ##STR25## wherein Y is the C-5' oxygen group of a deoxyribonucleic acid; and R 3 is alkyl.
Claim 3
Dependent Claim 10 words
The compound of claim 1, wherein R 3 is methyl.
Claim 4
Dependent Claim 47 words
The compound of claim 1 having the formula: ##STR26## wherein B is selected from the group consisting of adenyl, guanyl, cytidyl, thymidyl, and uridyl; and X is hydrogen, a solid support, an oligonucleotide or an activated phosphorous group selected from the group consisting of phosphotriester and phosphoramidite.
Claim 5
Dependent Claim 11 words
The compound of claim 3, wherein X is a solid support.
Claim 6
Dependent Claim 9 words
The compound of claim 4, wherein B is adenyl.
Claim 7
Dependent Claim 9 words
The compound of claim 4, wherein B is guanyl.
Claim 8
Dependent Claim 9 words
The compound of claim 4, wherein B is cytidyl.
Claim 9
Dependent Claim 9 words
The compound of claim 4, wherein B is thymidyl.
Claim 10
Dependent Claim 9 words
The compound of claim 4, wherein B is uridyl.
Claim 11
Dependent Claim 10 words
The compound of claim 4, wherein R 3 is methyl.
Claim 12
Dependent Claim 9 words
The compound of claim 10, wherein B is adenyl.
Claim 13
Dependent Claim 9 words
The compound of claim 10, wherein B is guanyl.
Claim 14
Dependent Claim 9 words
The compound of claim 10, wherein B is cytidyl.
Claim 15
Dependent Claim 9 words
The compound of claim 10, wherein B is thymidyl.
Claim 16
Dependent Claim 9 words
The compound of claim 10, wherein B is uridyl.
Claim 17
Dependent Claim 10 words
The compound of claim 3, wherein X is an oligonucleotide.
Claim 18
Dependent Claim 10 words
The compound of claim 16, wherein R 3 is methyl.
Claim 19
Dependent Claim 9 words
The compound of claim 17, wherein B is adenyl.
Claim 20
Dependent Claim 9 words
The compound of claim 17, wherein B is guanyl.
Claim 21
Dependent Claim 9 words
The compound of claim 17, wherein B is cytidyl.
Claim 22
Dependent Claim 9 words
The compound of claim 17, wherein B is thymidyl.
Claim 23
Dependent Claim 9 words
The compound of claim 17, wherean B is uridyl.
Claim 24
Dependent Claim 14 words
The compound of claim 16, wherean said oligonucleotide is attached to a synthesis substrate.
Claim 25
Dependent Claim 10 words
The compound of claim 23, wherein R 3 is methyl.
Claim 26
Dependent Claim 9 words
The compound of claim 23, wherein B is adenyl.
Claim 27
Dependent Claim 9 words
The compound of claim 23, wherein B is guanyl.
Claim 28
Dependent Claim 9 words
The compound of claim 23, wherean B is cytidyl.
Claim 29
Dependent Claim 9 words
The compound of claim 23, wherein B is thymidyl.
Claim 30
Dependent Claim 9 words
The compound of claim 23, wherean B is uridyl.
Claim 31
Dependent Claim 17 words
The compound of claim 3, wherein X is selected from the group consisting of phosphatetriester and phosphoramidite.
Claim 32
Dependent Claim 9 words
The compound of claim 30, wherein B is adenyl.
Claim 33
Dependent Claim 9 words
The compound of claim 30, wherein B is guanyl.
Claim 34
Dependent Claim 9 words
The compound of claim 30, wherein B is thymidyl.
Claim 35
Dependent Claim 9 words
The compound of claim 30, wherein B is cytidyl.
Claim 36
Dependent Claim 9 words
The compound of claim 30, wherein B is uridyl.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1999-02-05 1999-08-07 2000-02-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2003-02-05 2003-08-07 2004-02-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2007-02-05 2007-08-07 2008-02-06 $7700.00 Window Closed / Lapsed

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