Hydrogel compositions and structures made from same

Claim 2

A corneal implant comprising a lens body which is optically clear and structured and adapted to be surgically attached in or on the cornea of a mammalian eye, and is made of a hydrogel composition comprising water and a copolymer formed by reacting about 85% to about 99% by weight of at least one member selected from the group consisting of N,N-dimethylacrylamide, N,N-diethylacrylamide, N-methyl, N-ethylacrylamide and mixtures thereof; about 1% to about 15% by weight of at least one compound selected from the group consisting of, alkyl methacrylates and mixtures thereof, wherein the alkyl group contains 1 to 4 carbon atoms; and a minor, effective amount of at least one cross-linking agent, said lens body having sufficient glucose diffusivity so as to allow the cornea to which said lens body is to be surgically attached to have effective access to nutrients for corneal cell growth and maintenance, and having enhanced glucose diffusivity relative to a reference hydrogel composition of water and a copolymer derived from reacting a combination of monomers containing 70% by weight of said at least one member and 30% by weight of said at least one compound and an identical amount of said at least one cross-linking agent.

Claim 3

The corneal implant of claim 1 wherein water is present in said hydrogel composition in an amount of at least about 80% by weight, based on the total weight of said hydrogel composition.

Claim 4

The corneal implant of claim 1 wherein water is present in said hydrogel composition in an amount of at least about 90% by weight, based on the total weight of said hydrogel composition.

Claim 5

The corneal implant of claim 1 wherein said copolymer is formed by reacting about 90% to about 98% by weight of said at least one member and about 2% to about 10% by weight of said at least one compound.

Claim 6

The corneal implant of claim 1 wherein said hydrogel composition further comprises at least one cytophilic component in an amount effective to enhance the cytophilicity of said hydrogel composition.

Claim 7

A corneal implant comprising a lens body which is optically clear and is surgically attached in or on the cornea of a mammalian eye, and is made of a hydrogel composition comprising water and a copolymer formed by reacting a major amount by weight of at least one member selected from the group consisting of N,N-dimethylacrylamide, N,N-diethylacrylamide, N-methyl, N-ethylacrylamide and mixtures thereof; a minor amount by weight of at least one compound selected from the group consisting of alkyl acrylates, alkyl methacrylates and mixtures thereof, wherein the alkyl group contains 1 to 4 carbon atoms; and a minor, effective amount of at least one cross-linking agent, wherein the amount of water present is equal to at least 80%, based on the total weight of said hydrogel composition, said lens body having sufficient glucose diffusivity so as to allow the cornea to which said lens body is to be surgically attached to have effective access to nutrients for corneal cell growth and maintenance, and having enhanced glucose diffusivity relative to a reference hydrogel composition of water and a copolymer derived from reacting a combination of monomers containing 70% by weight of said at least one member and 30% by weight of said at least one compound and an identical amount of said at least one cross-linking agent.

Claim 8

A corneal implant comprising a lens body which is optically clear and is surgically attached in or on the cornea of a mammalian eye, and is made of a hydrogel composition comprising water and a copolymer formed by reacting a major amount by weight of at least one member selected from the group consisting of N,N-dimethylacrylamide, N,N-diethylacrylamide, N-methyl, N-ethylacrylamide and mixtures thereof; a minor amount by weight of at least one compound selected from the group consisting of alkyl acrylates, alkyl methacrylates and mixtures thereof, wherein the alkyl group contains 1 to 4 carbon atoms; and a minor, effective amount of at least one cross-linking agent, wherein the amount of water present is equal to at least 80%, based on the total weight of said hydrogel composition, said lens body having sufficient glucose diffusivity so as to allow the cornea to which said lens body is to be surgically attached to have effective access to nutrients for corneal cell growth and maintenance, and having enhanced glucose diffusivity relative to a reference hydrogel composition of water and a copolymer derived from reacting a combination of monomers containing 70% by weight of said at least one member and 30% by weight of said at least one compound and an identical amount of said at least one cross-linking agent.

Claim 9

The corneal implant of claim 6 wherein water is present in said hydrogel composition in an amount of at least about 90% by weight, based on the total weight of said hydrogel composition.

Claim 10

The corneal implant of claim 6 wherein said hydrogel composition further comprises at least one cytophilic component in an amount effective to enhance the cytophilicity of said hydrogel composition.

Claim 11

The corneal implant of claim 1 wherein said lens body has a glucose diffusivity of about 5.17×10 -6 cm 2 /sec or greater.

Claim 12

The corneal implant of claim 6 wherein said lens body has a glucose diffusivity of about 5.17×10 -6 cm 2 /sec or greater.