US4740498A
Expired / Lapsed
US
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Fibronectin preparations
Assignee: Tanabe Pharma Corp
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Filing: 1985-10-23
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Granted: 1988-04-26
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Expires: 2005-10-23
Abstract
Abstract A fibronectin preparation in the form of an aqueous solution at least upon use is disclosed. The preparation contains at least one member selected from the group consisting of disaccharides, albumin and nonionic surface active agents as a stabilizer. The preparation has improved water-solubility when in use and high stability in an aqueous solution.
Inventors
- 👤 Yutaka Hirao
- 👤 Takao Ohmura
- 👤 Kazuo Takechi
- 👤 Tsunetaka Nakajima
- 👤 Masayuki Nishida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:55
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/42; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61K47/06; A61K47/08; A61K47/10; A61K47/26; A61K9/00; A61K9/0012; A61K9/0048
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
54 words
A fibronectin preparation in the form of an aqueous isotonic eyedrop solution having a pH of 6 to 7, which contains 250 to 1,000 μg/ml of substantially pure fibronectin as an active ingredient and 20 to 500 μg/ml of polyoxyethylene-polyoxypropylene copolymer nonionic surface active agent as a stabilizer, said preparation not containing a carbohydrate.
Claim 2
Dependent Claim
54 words
A fibronectin preparation in the form of an aqueous isotonic eyedrop solution having a pH of 6 to 7, which contains 250 to 1,000 μg/ml of substantially pure fibronectin as an active ingredient and 20 to 500 μg/ml of polyoxyethylene-polyoxypropylene copolymer nonionic surface active agent as a stabilizer, said preparation not containing a carbohydrate.
Claim 3
Dependent Claim
24 words
The fibronectin preparation as claimed in claim 1, wherin the nonionic surface active agent has an average molecular weight of from 2,000 to 20,000.
Claim 4
Dependent Claim
27 words
The fibronectin preparation as claimed in claim 1, wherein the amount of said nonionic surface active agent in an aqueous solution is from 20 to 100 μg/ml.
Claim 5
Dependent Claim
73 words
A process for preparing a stable isotonic eyedrop solution of fibronectin having a pH of 6 to 7 which comprises admixing in aqueous solution 250 to 1,000 μg/ml of substantially pure fibronectin as an active ingredient and 20 to 500 μg/ml of polyoxyethyelene-polyoxypropylene copolymer nonionic surface active agent as a stabilizer, said process not including use of a carbohydrate and regulating the pH of said solution to be within pH 6 to 7.
Claim 6
Dependent Claim
73 words
A process for preparing a stable isotonic eyedrop solution of fibronectin having a pH of 6 to 7 which comprises admixing in aqueous solution 250 to 1,000 μg/ml of substantially pure fibronectin as an active ingredient and 20 to 500 μg/ml of polyoxyethyelene-polyoxypropylene copolymer nonionic surface active agent as a stabilizer, said process not including use of a carbohydrate and regulating the pH of said solution to be within pH 6 to 7.
Claim 7
Dependent Claim
24 words
The process of claim 4, wherein the amount of said nonionic surface active agent in an aqueous solution is from 20 to 100 μg/ml.
Claim 8
Dependent Claim
21 words
The process of claim 4, wherein the nonionic surface active agent has an average molecular weight of from 2,000 to 20,000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-26 | 1991-10-26 | 1992-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-26 | 1995-10-26 | 1996-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-26 | 1999-10-26 | 2000-04-26 | $7700.00 | Window Closed / Lapsed |