US4424206A
Expired / Lapsed
US
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Process for heat treatment of aqueous solution containing cold insoluble globulin to inactivate hepatitis virus
Assignee: Tanabe Pharma Corp
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Filing: 1982-02-22
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Granted: 1984-01-03
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Expires: 2002-02-22
Abstract
Abstract Cold insoluble globulin which may have hepatitis virus activity can be virus-inactivated with keeping at a minimum the damage of the cold insoluble globulin by heating its aqueous solution at 50 DEG to 80 DEG C. for 5 to 20 hours in the presence of 10% (W/V) or more of at least one principal stabilizer of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols with or without 10% (W/V) or more of at least one auxiliary stabilizer of salts of hydrocarbon carboxylic acids or hydroxyhydrocarbon carboxylic acids both having 3 to 10 carbon atoms.
Inventors
- 👤 Takao Ohmura
- 👤 Yutaka Hirao
- 👤 Satoshi Funakoshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 22:48
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K39/00; A61K39/395; A61L; A61L2/00; A61L2/02; A61L2/04; A61K38/00; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
83 words
A process for heat treatment to inactivate the hepatitis virus in a cold insoluble globuline, which comprises carrying out the heat treatment at 50° to 80° C. of an aqueous solution containing the cold insoluble globulin for a time sufficient to inactivate the hepatitis virus but to retain the activity of the cold insoluble globulin said aqueous solution also containing 10% W/V or more of at least one stabilizer selected from the group consisting of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols.
Claim 2
Dependent Claim
83 words
A process for heat treatment to inactivate the hepatitis virus in a cold insoluble globuline, which comprises carrying out the heat treatment at 50° to 80° C. of an aqueous solution containing the cold insoluble globulin for a time sufficient to inactivate the hepatitis virus but to retain the activity of the cold insoluble globulin said aqueous solution also containing 10% W/V or more of at least one stabilizer selected from the group consisting of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols.
Claim 3
Dependent Claim
50 words
The process according to claim 1, wherein the heat treatment is carried out in the additional presence of 10% W/V or more of at least one another stabilizer selected from the group consisting of salts of hydrocarbon carboxylic acids and hydroxyhydrocarbon carboxylic acids, which have 3 to 10 carbon atoms.
Claim 4
Dependent Claim
23 words
The process according to claim 1 or 2, wherein the neutral amino acid is present and is glycine, alanine, valine, leucine or isoleucine.
Claim 5
Dependent Claim
20 words
The process according to claim 1 or 2, wherein the monosaccharide is present and is glucose, mannose, galactose or fructose.
Claim 6
Dependent Claim
19 words
The process according to claim 1 or 2, wherein the disaccharide is present and is sucrose, maltose or lactose.
Claim 7
Dependent Claim
20 words
The process according to claim 1 or 2, wherein the sugar alcohol is present and is mannitol, sorbitol or xylitol.
Claim 8
Dependent Claim
19 words
The process according to claim 1 or 2, wherein the stabilizer is present in an amount of 10-50% W/V.
Claim 9
Dependent Claim
12 words
The process according to claim 7, wherein the amount is 10-30% W/V.
Claim 10
Dependent Claim
20 words
The process according to claim 1 or 2, wherein the heat treatment is carried out for 5 to 20 hours.
Claim 11
Dependent Claim
25 words
The process according to claim 1 or 2, wherein the aqueous solution contains the cold insoluble globulin in a concentration of 0.1 to 10% W/V.
Claim 12
Dependent Claim
32 words
The process according to claim 1 or 2, wherein the heat treatment is carried out at a pH of 5-10 of the aqueous solution which has been made into a buffer solution.
Claim 13
Dependent Claim
31 words
The process according to claim 2, wherein the hydrocarbon carboxylic acid is propanoic acid, butanoic acid, pentanoic acid, caprylic acid, caproic acid, malonic acid, succinic acid, glutaric acid or adipic acid.
Claim 14
Dependent Claim
17 words
The process according to claim 2, wherein the hydroxyhydrocarbon carboxylic acid is citric acid or mandelic acid.
Claim 15
Dependent Claim
15 words
The process according to claim 2, wherein the salt is a sodium or potassium salt.
Claim 16
Dependent Claim
18 words
The process according to claim 2, wherein the another stabilizer is present in an amount of 10-30% W/V.
Claim 17
Dependent Claim
23 words
The process according to claim 1 or 2 wherein the heat treatment is carried out for about 10 hours at about 50°-70° C.
Claim 18
Dependent Claim
23 words
The process according to claim 1 or 2 wherein the heat treatment is carried out for about 10 hours at about 60° C.
References Cited (Backward Citations)
US4327086A
Cited
US4305871A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-02 | 1987-07-04 | 1988-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-02 | 1991-07-04 | 1992-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-02 | 1995-07-04 | 1996-01-03 | $7700.00 | Window Closed / Lapsed |