EP0106608A2
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EP
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Method of lyophilizing cold insoluble globulin
Assignee: Tanabe Pharma Corp
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Filing: 1983-09-30
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Granted: —
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Expires: 2003-09-30
Abstract
Abstract A lyophilized cold insoluble globulin preparation can be prepared in a stable condition and in a short time by lyophilizing an aqueous solution of a cold insoluble globulin in the presence of albumin and a neutral amino acid, a monosaccharide, a disaccharide or a sugar alcohol. The preparation dissolves in water without occurrence of turbidity and is usable for injection.
Inventors
- 👤 Takao Ohmura
- 👤 Yutaka Hirao
- 👤 Takuji Hanamura
- 👤 Akimasa Ohmizu
- 👤 Satoshi Funakoshi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 22:11
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
65 words
A method of lyophilizing an acueous solution of a cold insoluble globulin comprising lyophilizing the solution in the presence of albumin and at least one stabilizer selected from the group consisting of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols, the amounts of albumin and the stabilizer being sufficient for preventing the occurrence of turbidity when the lyophilized cold insoluble globulin is dissolved in water.
Claim 2
Independent Claim
65 words
A method of lyophilizing an acueous solution of a cold insoluble globulin comprising lyophilizing the solution in the presence of albumin and at least one stabilizer selected from the group consisting of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols, the amounts of albumin and the stabilizer being sufficient for preventing the occurrence of turbidity when the lyophilized cold insoluble globulin is dissolved in water.
Claim 3
Dependent Claim
21 words
The method according to Claim 1, wherein the neutral amino acid is present and is glycine, alanine, valine, leucine or isoleucine.
Claim 4
Dependent Claim
19 words
The method according to Claim 1, wherein the monosaccharide is present and is glucose, mannose, galactose or fructose. -
Claim 5
Dependent Claim
17 words
The method according to Claim 1, wherein the disaccharide is present and is sucrose, maltose or lactose.
Claim 6
Dependent Claim
18 words
The method according to Claim 1, wherein the sugar alcohol is present and is mannitol, sorbitol or xylitol.
Claim 7
Independent Claim
41 words
The method according to anyone of Claims 1 to 5, wherein the amount of the stabilizer is selected from the range of 1 - 10 W/V, and the amount of albumin is selected from the range of 0.01 - 5% W/V.
Claim 8
Independent Claim
28 words
The method according to any one of Claims 1 to 6, wherein the aqueous solution contains the cold insoluble globulin in a concentration of 0.1 to 10% W/V.
Claim 9
Dependent Claim
32 words
A lyophilized cold insoluble globulin composition which contains a cold insoluble globulin, albumin and at least one member selected from the group consisting of neutral amino acids, monosaccharides, disaccharides and sugar alcohols.
Claim 10
Dependent Claim
32 words
A lyophilized cold insoluble globulin composition which contains a cold insoluble globulin, albumin and at least one member selected from the group consisting of neutral amino acids, monosaccharides, disaccharides and sugar alcohols.
References Cited (Backward Citations)
No citation records indexed.
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