US5401415A — Adsorption material for the selective removal of …

Claim 1

Independent Claim 159 words

Adsorption material for the selective removal of Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, said material consisting of: a) porous glass beads as a solid carrier material, and b) two or more different organic functional groups as ligands which are covalently bound via silanol groups present on their surface; i) wherein a first ligand corresponds to formula I ##STR2## in which x and y denote integers from 1 to 5, and ii) wherein a second or third ligand is selected from the group consisting of: ligands corresponding to formula II, --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CH.sub.2 --OH (II) in which x and y denote integers from 1 to 5, and ligands corresponding to formula III, --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CR.sub.1 R.sub.2 R.sub.3 (III) in which R 1 denotes a methoxy residue, R 2 and R 3 denote H or a methoxy residue, and x and y denote integers from 1 to 5, and wherein the material has no free silanol groups.

Claim 2

Dependent Claim 159 words

Adsorption material for the selective removal of Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, said material consisting of: a) porous glass beads as a solid carrier material, and b) two or more different organic functional groups as ligands which are covalently bound via silanol groups present on their surface; i) wherein a first ligand corresponds to formula I ##STR2## in which x and y denote integers from 1 to 5, and ii) wherein a second or third ligand is selected from the group consisting of: ligands corresponding to formula II, --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CH.sub.2 --OH (II) in which x and y denote integers from 1 to 5, and ligands corresponding to formula III, --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CR.sub.1 R.sub.2 R.sub.3 (III) in which R 1 denotes a methoxy residue, R 2 and R 3 denote H or a methoxy residue, and x and y denote integers from 1 to 5, and wherein the material has no free silanol groups.

Claim 3

Dependent Claim 21 words

The adsorption material as claimed in claim 1, wherein one of the organic functional groups has 1-aminoethyl-3-oxypropyl residues as the ligands.

Claim 4

Dependent Claim 36 words

The adsorption material as claimed in claim 1, wherein ligands having the formulae I, II and III are present and bound to the carrier material via silanol groups in a quantity ratio of 1.3: 1: 0.8.

Claim 5

Dependent Claim 44 words

The adsorption material as claimed in claim 1, wherein the ligands having the formulae I and II are present bound to the carrier material via silanol groups in a quantity ratio of 1:1, 1:2, 1:3 and 1:4 as well as 2:1, 3:1 and 4:1.

Claim 6

Dependent Claim 20 words

The adsorption material as claimed in claim 1, wherein the material has a surface of to 300 m 2 /g.

Claim 7

Dependent Claim 26 words

The adsorption material as claimed in claim 1, wherein the degree of covering of the carrier material with ligands is 2 to 20 μmol/m 2 .

Claim 8

Dependent Claim 30 words

The adsorption material as claimed in claim 1, wherein the glass beads have a particle diameter of 60 to 500 μm and a pore diameter of 50 to 350 nm.

Claim 9

Dependent Claim 29 words

A process for the removal of LDL cholesterol and/or vLDL cholesterol and/or Lp(a) lipoprotein from aqueous liquids, wherein the liquid is passed over the adsorption material of claim 1.

Claim 10

Dependent Claim 20 words

The method of claim 8 wherein the aqueous liquid is selected from the group consisting of blood, plasma and serum.

Claim 11

Dependent Claim 64 words

A method for the determination of the concentration of LDL cholesterol and/or VLDL cholesterol and/or Lp(a) lipoprotein in aqueous liquids, wherein a) LDL cholesterol and vLDL cholesterol and Lp(a) lipoprotein are separated chromatographically with the aid of the adsorption material of claim 1; and b) after elution from the adsorption material, the concentrations of LDL cholesterol and VLDL cholesterol and Lp(a) lipoprotein are determined.

Claim 12

Dependent Claim 23 words

The method of claim 10, wherein the elution is carried out with high molecular saline solution, a glycerol-water mixture or a urea solution.

Claim 13

Dependent Claim 54 words

A device for the extracorporeal removal of LDL cholesterol and/or vLDL cholesterol and/or Lp(a) lipoprotein from aqueous liquids, wherein the device consists of a cylindrical housing which is filled with the adsorption material of claim 1 and which is provided with covers at both ends which each have a central inflow or outflow pipe.

Claim 14

Dependent Claim 24 words

The device of claim 12, wherein the housing has a diameter of 3 to 20 cm and a length of 1 to 40 cm.

Claim 15

Dependent Claim 24 words

The device of claim 13 wherein the housing has a diameter of 5 to 10 centimeters and a length of 10 to 20 centimeters.

Claim 16

Dependent Claim 14 words

The device of claim 12 wherein the housing is made of glass or plastic.

Claim 17

Dependent Claim 27 words

The device of claim 12, wherein the cover of the housing at the inflow side has a sieve with a pore size of 10 to 300 μm.

Claim 18

Dependent Claim 27 words

The device of claim 16 wherein the cover of the housing at the inflow side has a sieve with a pore size of 20 to 100 μm.

Claim 19

Dependent Claim 40 words

The device of claim 12, wherein the housing is integrated into a closed circulation in which the aqueous liquid, from which the LDL cholesterol and/or vLDL cholesterol and/or Lp(a) lipoprotein are being removed, is circulated by means of a pump.

Claim 20

Dependent Claim 30 words

The device of claim 12, wherein a further cylindrical housing filled with the adsorption material and provided with covers and inflow and outflow pipes is located in the closed circulation.

Claim 21

Dependent Claim 107 words

Adsorption material for the selective removal of Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, said material consisting of: a) porous glass beads as a solid carrier material, and b) two or more different organic functional groups as ligands which are covalently bound via silanol groups present on their surface; i) wherein a first ligand corresponds to formula I ##STR3## in which x and y denote integers from 1 to 5 and ii) a second ligand corresponds to formula II --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CH.sub.2 --OH (II) in which x and y denote integers from 1 to 5, and wherein the material has no free silanol groups.

Claim 22

Dependent Claim 107 words

Adsorption material for the selective removal of Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, said material consisting of: a) porous glass beads as a solid carrier material, and b) two or more different organic functional groups as ligands which are covalently bound via silanol groups present on their surface; i) wherein a first ligand corresponds to formula I ##STR3## in which x and y denote integers from 1 to 5 and ii) a second ligand corresponds to formula II --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CH.sub.2 --OH (II) in which x and y denote integers from 1 to 5, and wherein the material has no free silanol groups.

Claim 23

Dependent Claim 23 words

The adsorption material as claimed in claim 20, wherein the material contains one or several 1-hydroxyethyl-3-oxybutyl residues as the ligands of formula II.

Claim 24

Dependent Claim 23 words

The adsorption material as claimed in claim 20, wherein the material contains one or several 1-hydroxypropyl-3-oxypropyl residues as the ligands of formula II.

Claim 25

Dependent Claim 126 words

Adsorption material for the selective removal of Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, said material consisting of: a) porous glass beads as a solid carrier material; and b) two or more different organic functional groups as ligands which are covalently bound via silanol groups present on their surface; i) wherein a first ligand corresponds to formula I ##STR4## in which x and y denote integers from 1 to 5 and ii) a third ligand corresponds to formula III --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CR.sub.1 R.sub.2 R.sub.3 (III) in which R 1 denotes a methoxy residue, R 2 and R 3 denote H or a methoxy residue, and x and y denote integers from 1 to 5, and wherein the material has no free silanol groups.

Claim 26

Dependent Claim 126 words

Adsorption material for the selective removal of Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, said material consisting of: a) porous glass beads as a solid carrier material; and b) two or more different organic functional groups as ligands which are covalently bound via silanol groups present on their surface; i) wherein a first ligand corresponds to formula I ##STR4## in which x and y denote integers from 1 to 5 and ii) a third ligand corresponds to formula III --(CH.sub.2).sub.x --O--(CH.sub.2).sub.y --CR.sub.1 R.sub.2 R.sub.3 (III) in which R 1 denotes a methoxy residue, R 2 and R 3 denote H or a methoxy residue, and x and y denote integers from 1 to 5, and wherein the material has no free silanol groups.

Claim 27

Dependent Claim 23 words

The adsorption material as claimed in claim 23, wherein the material contains one or several 1,1-dimethoxyethyl-3-oxypropyl residues as the ligands of formula III.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-03-27	1998-09-26	1999-03-28	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-03-27	2002-09-26	2003-03-28	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-03-27	2006-09-26	2007-03-28	$7700.00	Window Closed / Lapsed

Adsorption material for the selective removal of LDL and/or vLDL and method of using therefor

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