EP0244802A2
Expired / Lapsed
EP
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Substituted silica
Assignee: Yeda Research and Development Co Ltd
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Filing: 1987-05-04
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Granted: —
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Expires: 2007-05-04
Abstract
Abstract The invention relates to modified silica, substituted with a variety of substituents. There is provided a product termed primary hydroxyl silica where there are attached to the silica substituents bearing a single hydroxyl group. Furthermore there are provided a wide variety of derivatives of such hydroxy-silica, which are of value in affinity chromatography and for various other uses. The products combine the thermal and mechanical stability of the silica used as carrier with the useful properties of the substituents.
Inventors
- 👤 Meir Wilchek
- 👤 Karin Cabrera
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 03:24
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/289; B01J20/02; B01J20/10; B01J20/103; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/28054; B01J20/28078; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3259; B01J20/3261; B01J20/3263; B01J20/3268; B01J20/3272; B01J20/3274; B01J2220/00; B01J2220/50; B01J2220/54; B01J2220/58
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
82 words
A compound of the general formula wherein: Alk is lower alkyl, and where: a. the compound is a primary hydroxy silica compound, wherein R is hydroxyl or R is -(CH₂) n -O-CH₂) m -CH₂-OH, b. a derivative thereof wherein: R is -O-(CH₂) m -R¹-OR², R¹ is a group selected from: R² is selected from: where Q is a group -HN-(CH₂) n -NH₂, -HN-(CH₂) n -COOH, -HN-peptide or -HN-protein, where n, m and p are small integers, where m may also be zero.
Claim 2
Dependent Claim
82 words
A compound of the general formula wherein: Alk is lower alkyl, and where: a. the compound is a primary hydroxy silica compound, wherein R is hydroxyl or R is -(CH₂) n -O-CH₂) m -CH₂-OH, b. a derivative thereof wherein: R is -O-(CH₂) m -R¹-OR², R¹ is a group selected from: R² is selected from: where Q is a group -HN-(CH₂) n -NH₂, -HN-(CH₂) n -COOH, -HN-peptide or -HN-protein, where n, m and p are small integers, where m may also be zero.
Claim 3
Dependent Claim
24 words
A compound according to claim 1, of the formula where Alk designates lower alkyl and where n is an integer from 1 to 5.
Claim 4
Dependent Claim
23 words
A compound according to claim 1, of the formula where m and n are each a small integer of from 1 to 5.
Claim 5
Dependent Claim
33 words
A compound according to claim 2 or 3, wherein there is provided in said molecule a spacer of the type -HN-(CH₂) n -NH- or -HN-(CH₂) n -CO-, where n is a small integer.
Claim 6
Dependent Claim
33 words
Modified silica according to any of claims 1 to 4, of irregular or spherical particle form, of a pore size in the range of from 3 µm and up to about 200 mm.
Claim 7
Dependent Claim
15 words
Modified silica according to claim 5, of particle size of 3 µm to 200 µm.
Claim 8
Dependent Claim
22 words
A column for use in HPAC, LPAC, protein immobilization comprising modified activated silica as claimed in any of claims 1 to 6.
Claim 9
Dependent Claim
57 words
A process for the production of primary hydroxyl silica as claimed in claim 1, which comprises reacting the intermediate of Formula (2) with a suitable oxidizing agent to provide the intermediate (3) which is reacted with sodium borohydride (NaBH₄) to provide the desired compound of Formula (4) where m and n are as defined in claim 1.
Claim 10
Dependent Claim
36 words
A process according to claim 8, where the product of Formula (4) is activated by reaction with a chloroformate or with a 1,1ʹ-carbodiimidazole, with tresylchloride, with 1,1,1-trichloro-2-monochlorethylsuccinimide carbonate, or by a sulfonylchloride or with cyanogen bromide.
Claim 11
Dependent Claim
13 words
A process according to claim 9 where the chloroformate is of the formula
Claim 12
Dependent Claim
13 words
A process according to claim 9 where the 1,1ʹ-carbodiimidazole is of the formula
References Cited (Backward Citations)
No citation records indexed.
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