Patent US4539729A successfully refreshed from Google Patents.
Patent US5396178A successfully refreshed from Google Patents.
US5396178A
Expired / Lapsed
US
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Apparatus and method for determining that equipment is clean
Assignee: Dober Chemical Corp
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Filing: 1992-05-18
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Granted: 1995-03-07
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Expires: 2012-05-18
Abstract
Abstract Apparatus and methods for determining that a piece of equipment, for example, used in the biotechnology or pharmaceutical industries, is clean are disclosed. The invention involves measuring the electrical conductivity of an aqueous liquid medium both before and after the medium is used to contact, e.g., rinse, the piece of equipment. The equipment is determined to be clean when these two measured electrical conductivities are substantially equal.
Inventors
- 👤 Robert J. Rybarski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:13
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/02; G01N27/04; G01N27/06; G01N27/021; G01N27/08; G01N27/10
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
111 words
A method for determining that a piece of equipment is clean which comprises: (a) causing an aqueous liquid rinse medium to come into contact with said piece of equipment; (b) determining the electrical conductivity of said aqueous liquid medium prior to said aqueous liquid rinse medium being used in step (a); (c) determining the electrical conductivity of said aqueous liquid rinse medium after said aqueous liquid rinse medium is used in step (a); and (d) comparing the electrical conductivities determined in steps (b) and (c), said piece of equipment being determined to be clean when said electrical conductivity determined in step (c) substantially equals said electrical conductivity determined in step (b).
Claim 2
Independent Claim
111 words
A method for determining that a piece of equipment is clean which comprises: (a) causing an aqueous liquid rinse medium to come into contact with said piece of equipment; (b) determining the electrical conductivity of said aqueous liquid medium prior to said aqueous liquid rinse medium being used in step (a); (c) determining the electrical conductivity of said aqueous liquid rinse medium after said aqueous liquid rinse medium is used in step (a); and (d) comparing the electrical conductivities determined in steps (b) and (c), said piece of equipment being determined to be clean when said electrical conductivity determined in step (c) substantially equals said electrical conductivity determined in step (b).
Claim 3
Dependent Claim
31 words
The method of claim 1 wherein said aqueous liquid rinse medium prior to being used in step (a) has an electrical conductivity of less than about 5 microsiemens per square cm.
Claim 4
Dependent Claim
21 words
The method of claim 1 wherein steps (b), (c) and (d) are performed substantially continuously while step (a) is being performed.
Claim 5
Dependent Claim
38 words
The method of claim 3 wherein said piece of equipment is determined to be clean when said electrical conductivity determined in step (c) substantially equals said electrical conductivity determined in step (b) for a predetermined period of time.
Claim 6
Dependent Claim
41 words
The method of claim 3 wherein said piece of equipment is determined to be clean when said electrical conductivity determined in step (c) is within at least about 0.1 microsiemen per square cm of said electrical conductivity determined in step (b).
Claim 7
Dependent Claim
38 words
The method of claim 1 wherein said piece of equipment is determined to be clean when said electrical conductivity determined in step (c) substantially equals said electrical conductivity determined in step (b) for a predetermined period of time.
Claim 8
Dependent Claim
41 words
The method of claim 1 wherein said piece of equipment is determined to be clean when said electrical conductivity determined in step (c) is within at least about 0.1 microsiemen per square cm of said electrical conductivity determined in step (b).
Claim 9
Dependent Claim
28 words
The method of claim 1 which further comprises treating said piece of equipment prior to performing step (a) to remove debris or contaminants from said piece of equipment.
Claim 10
Dependent Claim
21 words
The method of claim 1 which further comprises providing a signal when said piece of equipment is determined to be clean.
Claim 11
Dependent Claim
28 words
The method of claim 1 which further comprises employing said piece of equipment in the biotechnology industry or in the pharmaceutical industry after being determined to be clean.
Claim 12
Independent Claim
200 words
An apparatus for determining that a piece of equipment is clean which comprises: a first conductivity meter assembly located with respect to the piece of equipment to measure the electrical conductivity of an aqueous liquid rinse medium prior to the aqueous liquid rinse medium being used to contact the piece of equipment and to provide a first signal indicative of said electrical conductivity measured by said first conductivity meter assembly; a second conductivity meter assembly located with respect to the piece of equipment to measure the electrical conductivity of the aqueous liquid rinse medium after the aqueous liquid rinse medium is used to contact the piece of equipment and to provide a second signal indicative of said electrical conductivity measured by said second conductivity meter assembly; and a signal comparing assembly located so as to receive both said first signal and said second signal, said signal comparing assembly being structured to compare said first signal and said second signal and to provide a third signal when said electrical conductivity measured by said second conductivity meter assembly substantially equals said electrical conductivity measured by said first conductivity meter assembly, said third signal being indicative that said piece of equipment is clean.
Claim 13
Independent Claim
200 words
An apparatus for determining that a piece of equipment is clean which comprises: a first conductivity meter assembly located with respect to the piece of equipment to measure the electrical conductivity of an aqueous liquid rinse medium prior to the aqueous liquid rinse medium being used to contact the piece of equipment and to provide a first signal indicative of said electrical conductivity measured by said first conductivity meter assembly; a second conductivity meter assembly located with respect to the piece of equipment to measure the electrical conductivity of the aqueous liquid rinse medium after the aqueous liquid rinse medium is used to contact the piece of equipment and to provide a second signal indicative of said electrical conductivity measured by said second conductivity meter assembly; and a signal comparing assembly located so as to receive both said first signal and said second signal, said signal comparing assembly being structured to compare said first signal and said second signal and to provide a third signal when said electrical conductivity measured by said second conductivity meter assembly substantially equals said electrical conductivity measured by said first conductivity meter assembly, said third signal being indicative that said piece of equipment is clean.
Claim 14
Dependent Claim
15 words
The apparatus of claim 11 wherein said signal comparing assembly is structured to operate automatically.
Claim 15
Dependent Claim
45 words
The apparatus of claim 11 wherein both said first conductivity meter assembly and said second conductivity meter assembly are structured to substantially continuously measure the electrical conductivity of the aqueous liquid rinse medium while the aqueous liquid rinse medium is contacting the piece of equipment.
Claim 16
Dependent Claim
46 words
The apparatus of claim 13 wherein said signal comparing assembly is structured to provide said third signal when said electrical conductivity measured by said second conductivity meter assembly substantially equals said electrical conductivity measured by said first conductivity meter assembly for a predetermined period of time.
Claim 17
Dependent Claim
46 words
The apparatus of claim 11 wherein said signal comparing assembly is structured to provide said third signal when said electrical conductivity measured by said second conductivity meter assembly substantially equals said electrical conductivity measured by said first conductivity meter assembly for a predetermined period of time.
Claim 18
Dependent Claim
49 words
The apparatus of claim 15 wherein said third signal is provided when said electrical conductivity measured by said second conductivity meter assembly is within at least about 0.1 microsiemen per square cm of said electrical conductivity measured by said first conductivity meter assembly for a predetermined period of time.
Claim 19
Dependent Claim
34 words
The apparatus of claim 11 which further comprises an indicator assembly located so as to received said third signal and structured so as to provide an indication of the receipt of said third signal.
Claim 20
Dependent Claim
25 words
The apparatus of claim 17 wherein said indication is one or more of the following: an audible indication, a visual indication or a printed indicator.
Claim 21
Dependent Claim
18 words
The apparatus of claim 11 wherein said signal comparing assembly comprises a digital computer or an analog computer.
Claim 22
Dependent Claim
43 words
The apparatus of claim 11 wherein said third signal is provided when said electrical conductivity measured by said second conductivity meter assembly is within at least about 0.1 microsiemen per square cm of said electrical conductivity measured by said first conductivity meter assembly.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-03-06 | 1998-09-05 | 1999-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-06 | 2002-09-05 | 2003-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-06 | 2006-09-05 | 2007-03-07 | $7700.00 | Window Closed / Lapsed |