Patent US5379764A successfully refreshed from Google Patents.
US5379764A
Expired / Lapsed
US
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Non-invasive determination of analyte concentration in body of mammals
Assignee: Biocontrol Technology Inc
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Filing: 1992-12-09
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Granted: 1995-01-10
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Expires: 2012-12-09
Abstract
Abstract A method of non-invasive determination of the concentration of at least one analyte in the blood of a mammal, includes the steps of projecting near-infrared radiation on a portion of the body of the mammal, the radiation including a plurality of wavelengths; sensing the resulting radiation emitted from the portion of the body; deriving from the sensed resulting radiation emitted from the portion of the body a first expression for the magnitude of the sensed radiation as a function of wavelength of the sensed radiation; pretreating the first expression to minimize the influence of offset and drift to obtain a second expression for the magnitude of the sensed radiation as a function of wavelength; and performing multivariate analysis of the second expression to obtain a value for the concentration of the analyte.
Inventors
- 👤 Russell H. Barnes
- 👤 Jimmie W. Brasch, Sr.
- 👤 David L. Purdy
- 👤 William D. Lougheed
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:56
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14532; G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/35; G01N21/359
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
132 words
A method of non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising the steps of: (a) projecting near infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths; (b) sensing the resulting radiation emitted from said portion of the body; (c) deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation; (d) pretreating said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength; and (e) performing multivariate analysis of said second expression to obtain a value for the concentration of said analyte.
Claim 2
Independent Claim
132 words
A method of non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising the steps of: (a) projecting near infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths; (b) sensing the resulting radiation emitted from said portion of the body; (c) deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation; (d) pretreating said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength; and (e) performing multivariate analysis of said second expression to obtain a value for the concentration of said analyte.
Claim 3
Dependent Claim
25 words
The method of claim 1, wherein said step of pretreating said first expression comprises the step of obtaining the nth derivative of said first expression.
Claim 4
Dependent Claim
20 words
The method of claim 1, wherein said step (e) comprises the step of using the technique of partial least squares.
Claim 5
Dependent Claim
20 words
The method of claim 1, wherein said step (e) comprises the step of using the technique of principal component analysis.
Claim 6
Independent Claim
141 words
An apparatus for non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising: (a) means for projecting near-infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths; (b) means for sensing the resulting radiation emitted from said portion of the body; (c) means for deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation; and (d) data processing means adapted to (i) pretreat said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength and (ii) perform multivariate analysis of said second expression to obtain a value for the concentration of said analyte.
Claim 7
Independent Claim
141 words
An apparatus for non-invasive determination of the concentration of at least one analyte in the blood of a mammal, comprising: (a) means for projecting near-infrared radiation on a portion of the body of the mammal, said radiation including a plurality of wavelengths; (b) means for sensing the resulting radiation emitted from said portion of the body; (c) means for deriving from the sensed resulting radiation a first expression for the magnitude of said sensed radiation as a function of wavelength of the sensed radiation; and (d) data processing means adapted to (i) pretreat said first expression to minimize the influence of instrument offset and drift to obtain a second expression for the magnitude of said sensed radiation as a function of wavelength and (ii) perform multivariate analysis of said second expression to obtain a value for the concentration of said analyte.
Claim 8
Dependent Claim
26 words
The apparatus of claim 5, wherein said data processing means is adapted to pretreat said first expression by obtaining the nth derivative of said first expression.
Claim 9
Dependent Claim
27 words
The apparatus of claim 5, wherein said data processing means is adapted to perform multivariate analysis of said second expression using the technique of partial least squares.
Claim 10
Dependent Claim
27 words
The apparatus of claim 5, wherein said data processing means is adapted to perform multivariate analysis of said second expression using the technique of principal component analysis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-09 | 1998-07-11 | 1999-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-09 | 2002-07-11 | 2003-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-09 | 2006-07-11 | 2007-01-10 | $7700.00 | Window Closed / Lapsed |