US5077476A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Instrument for non-invasive measurement of blood glucose
Assignee: Futrex Inc
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Filing: 1990-08-10
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Granted: 1991-12-31
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Expires: 2010-08-10
Abstract
Abstract Near-infrared quantitative analysis instruments non-invasively measure blood glucose by analyzing near-infrared energy following interactance with venous or arterial blood, or transmission through a blood containing body part. A replaceable cartridge stores data unique to an individual patient/user. The analysis instruments are accurate and readily lend themselves to at-home testing by diabetics.
Inventors
- 👤 Robert D. Rosenthal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:09
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/35; G01N21/359; A; A61; A61B; A61B5/00; A61B5/145; A61B5/14532; A61B5/1455; A61B2560/00; A61B2560/04; A61B2560/0475
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
142 words
A near-infrared quantitative analysis instrument for non-invasive measurement of blood present in a body part of a subject, comprising: (a) introducing means including a near infrared energy source for introducing near-infrared energy into blood present in a body part of a subject; (b) detecting means for detecting near-infrared energy emerging from the body part; (c) positioning means for positioning both the near-infrared introducing means and the detecting means closely adjacent to the body part; (d) processing means for processing a first electrical signal produced by the detector means into a second signal indicative of the quantity of glucose present in the blood of the subject; (e) a housing means for housing said introducing means, said detecting means and said processing means; and (f) a replaceable cartridge means engaging said housing means comprising a memory means for storing data comprising said second signal.
Claim 2
Dependent Claim
142 words
A near-infrared quantitative analysis instrument for non-invasive measurement of blood present in a body part of a subject, comprising: (a) introducing means including a near infrared energy source for introducing near-infrared energy into blood present in a body part of a subject; (b) detecting means for detecting near-infrared energy emerging from the body part; (c) positioning means for positioning both the near-infrared introducing means and the detecting means closely adjacent to the body part; (d) processing means for processing a first electrical signal produced by the detector means into a second signal indicative of the quantity of glucose present in the blood of the subject; (e) a housing means for housing said introducing means, said detecting means and said processing means; and (f) a replaceable cartridge means engaging said housing means comprising a memory means for storing data comprising said second signal.
Claim 3
Dependent Claim
18 words
A near-infrared quantitative analysis instrument of claim 1 wherein said near-infrared energy source comprises an infrared emitting diode.
Claim 4
Dependent Claim
31 words
An analysis instrument of claim 1 wherein said introducing means comprises a filter means for selectively transmitting near-infrared energy, said filter means being disposed between said source and said body part.
Claim 5
Dependent Claim
41 words
An analysis instrument of claim 3 comprising a first filter means for selectively transmitting near-infrared energy of between about 780 and 810 nanometers and a second filter means for selectively transmitting near infrared energy of between about 1070 and 1090 nanometers.
Claim 6
Dependent Claim
38 words
An analysis instrument of claim 1 wherein said memory means for storing data is electrically connected to said processing means which comprises a clock means for storing times at which measurement data is stored in said memory means.
Claim 7
Dependent Claim
22 words
An analysis instrument of claim 5 wherein said memory means further comprises programmable means for storing software for operating the analytical instrument.
Claim 8
Dependent Claim
17 words
An analysis instrument of claim 6 wherein said programmable means comprises an erasable programmable read only memory.
Claim 9
Dependent Claim
23 words
An analysis instrument of claim 1 wherein said cartridge means further comprises a power source means for providing power to said analysis instrument.
Claim 10
Dependent Claim
34 words
An analysis instrument of claim 1 further comprising an input/output connection means for enabling data to be input to said processing means and for outputting to an external source data from said processing means.
Claim 11
Dependent Claim
15 words
An analysis instrument of claim 9 wherein said cartridge means comprises said input/output connection means.
Claim 12
Dependent Claim
24 words
An analysis instrument of claim 1 wherein said housing means comprises a retainer means for securely positioning said body part in said housing means.
Claim 13
Dependent Claim
23 words
An analysis instrument of claim 1 wherein said housing means further comprises means for shielding the detector means from exposure to ambient light.
Claim 14
Dependent Claim
23 words
An analysis instrument of claim 12 wherein said means for shielding the detector means comprises a cover rotatably secured to said housing means.
Claim 15
Dependent Claim
16 words
An analysis instrument of claim 1 further comprising a display means for displaying blood glucose level.
Claim 16
Dependent Claim
19 words
An analysis instrument of claim 14 wherein said display means displays blood glucose levels in mg/dl and mmol/L units.
Claim 17
Dependent Claim
40 words
An analysis instrument of claim 1 wherein said housing means further comprises a first temperature sensing means electrically connected to said processor means for sensing a skin temperature of said body part and producing a first temperature signal representative thereof.
Claim 18
Dependent Claim
38 words
An analysis instrument of claim 1 wherein said housing means further comprises a second temperature sensing means electrically connected to said processor means for sensing ambient temperature inside said instrument and producing a second temperature signal representative thereof.
Claim 19
Dependent Claim
89 words
An analysis instrument of claim 1 wherein the processing means processes the first signal according to the formula C=K.sub.0 +K.sub.1 [log 1/I.sub.A -log 1/I.sub.B ]+K.sub.2 T.sub.S wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is the line slope of [log1/I.sub.A -log1/I.sub.B ] K 2 is a calibration constant, log 1/I A and log 1/I B each represent an optical density value at corresponding wavelengths A and B and T S represents the local surface temperature of said body part.
Claim 20
Dependent Claim
94 words
An analysis instrument of claim 1 wherein the signal processing means processes the first signal according to the formula C=K.sub.0 +K.sub.1 [log1/I.sub.A -2*log1/I.sub.B +log1/I.sub.c ]+K.sub.2 T.sub.1 wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of [log1/I.sub.A -2*log1I.sub.B +1/I.sub.C ] K 2 is a calibration constant, log 1/I A , log 1/I B , and log 1/I C each represent an optical density value at corresponding wavelengths A, B and C, and Ts represents the local surface temperature of said body part.
Claim 21
Dependent Claim
90 words
An analysis instrument of claim 1 wherein the signal processing means processes the signal according to the formula ##EQU2## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is the line slope of ##EQU3## K 2 is a calibration constant, log 1/I A , log 1/I B , log 1/I D and log 1/I E each represent an optical density value at corresponding wavelengths A, B, D and E and T s represents the local surface temperature of said body part.
Claim 22
Dependent Claim
102 words
An analysis instrument of claim 1 wherein the signal processing means processes the signal according to the formula ##EQU4## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is the line slope of ##EQU5## K 2 is a calibration constant, log 1/I A , log 1/I B , log 1/I C , log 1/I D , log 1/I E , and log 1/I F each represent an optical density value at corresponding wavelengths A, B, C, D, E and F, and T s represents the local surface the temperature of said body part.
Claim 23
Dependent Claim
104 words
An analysis instrument of claim 1 wherein the first signal processing means processes the signal according to the formula ##EQU6## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is the line slope of ##EQU7## K 2 and K 3 are calibration constants, log 1/I A , log 1/I B , and log 1/I D and log 1/I E each represent an optical density value at corresponding wavelengths A, B, D and E, T s represents the local surface temperature of said body part and T A represents the ambient air temperature of said instrument.
Claim 24
Dependent Claim
113 words
An analysis instrument of claim 1 wherein the first signal processing means processes the signal according to the formula ##EQU8## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is the line slope of ##EQU9## K 2 and K 3 are calibration constants, log 1/I A , log 1/I B , log 1/I C , log 1/I D , log 1/I E , and log 1/I F each represent an optical density value at corresponding wavelengths A, B, C, D, E and F, T. represents the local surface the temperature of said body part and T A represents the ambient temperature of said instrument.
Claim 25
Dependent Claim
29 words
An analytical instrument of claim 1 further comprising protection means for requiring that said cartridge which is custom calibrated for an individual be used in a specific analytical instrument.
Claim 26
Dependent Claim
36 words
An analytical instrument of claim 24 wherein said protection means comprises storing at least one calibration constant in each said specific analytical instrument and said cartridge which must be matched before the analytical instrument will operate.
Claim 27
Dependent Claim
24 words
An analytical instrument of claim 1 further comprising speech synthesizer means for providing audio operational instructions and audio output corresponding to said second signal.
Claim 28
Dependent Claim
23 words
An analytical instrument of claim 1 wherein said processor means further comprises means for automatically correcting for bias drift in said second signal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-30 | 1995-07-01 | 1995-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-30 | 1999-07-01 | 1999-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-30 | 2003-07-01 | 2003-12-31 | $7700.00 | Window Closed / Lapsed |