US5028787A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-invasive measurement of blood glucose
Assignee: Futrex Inc
•
Filing: 1989-01-19
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Granted: 1991-07-02
•
Expires: 2009-01-19
Abstract
Abstract A near-infrared quantitative analysis instrument and method non-invasively measures blood glucose by analyzing near-infrared energy following interactance with venous or arterial blood, or transmission through a blood containing body part. The instrument and method is accurate and can readily be utilized for at-home testing by diabetics.
Inventors
- 👤 Robert D. Rosenthal
- 👤 Lynn N. Paynter
- 👤 Linda H. Mackie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 07:11
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/35; G01N21/359; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/0002; A61B5/0004; A61B5/0008; A61B5/14; A61B5/14532; G01N21/314; G01N21/3577
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
142 words
A near-infrared quantitative analysis instrument for non-invasive measurement of blood glucose in blood present in a body part of a subject, comprising: (a) means for introducing near-infrared energy into blood present in a body part of a subject; (b) a near-infrared detector for detecting near-infrared energy within the range of about 600 to 1110 nanometers emerging from the body part and for providing a signal upon detection of near-infrared energy within said range emerging from the body part; (c) means for positioning both the near-infrared introducing means and the near-infrared detector closely adjacent to the body part so that near-infrared energy detected by the detector corresponds to blood glucose level in said body part; and (d) means for processing the signal produced by the detector into a second signal indicative of the quantity of glucose present in the blood of the subject.
Claim 2
Dependent Claim
142 words
A near-infrared quantitative analysis instrument for non-invasive measurement of blood glucose in blood present in a body part of a subject, comprising: (a) means for introducing near-infrared energy into blood present in a body part of a subject; (b) a near-infrared detector for detecting near-infrared energy within the range of about 600 to 1110 nanometers emerging from the body part and for providing a signal upon detection of near-infrared energy within said range emerging from the body part; (c) means for positioning both the near-infrared introducing means and the near-infrared detector closely adjacent to the body part so that near-infrared energy detected by the detector corresponds to blood glucose level in said body part; and (d) means for processing the signal produced by the detector into a second signal indicative of the quantity of glucose present in the blood of the subject.
Claim 3
Dependent Claim
23 words
An analysis instrument of claim 1 further including means for preventing near-infrared energy from the introducing means from impinging directly on the detector.
Claim 4
Dependent Claim
26 words
An analysis instrument of claim 2 wherein said introducing means includes a near-infrared energy source and transmitting means for transmitting said energy into the body part.
Claim 5
Dependent Claim
16 words
An analysis instrument of claim 3 wherein said source comprises at least one infrared emitting diode.
Claim 6
Dependent Claim
21 words
An analysis instrument of claim 3 wherein said transmitting means comprises a lens for focusing said energy onto the body part.
Claim 7
Dependent Claim
36 words
An analysis instrument of claim 2 wherein said processing means comprises amplifier means for amplifying the signal provided by said detector, and data processing means for converting the signal from the detector into said second signal.
Claim 8
Dependent Claim
34 words
An analysis instrument of claim 1 wherein said introducing means includes a near infrared source and a filter for selectively transmitting near-infrared energy which filter is disposed between said source and said body part.
Claim 9
Dependent Claim
25 words
An analysis instrument of claim 7 for blood glucose measurement wherein said filter selectively transmits near-infrared energy of between about 600 and about 1100 nanometers.
Claim 10
Dependent Claim
18 words
An analysis instrument of claim 1 wherein said introducing means provides a bandwidth centered on about 980 nanometers.
Claim 11
Dependent Claim
26 words
An analysis instrument of claim 1 wherein said positioning means includes means for marking a position for said instrument over a blood vessel of a subject.
Claim 12
Dependent Claim
62 words
An analysis instrument of claim 1 wherein said positioning means comprises means for positioning said introducing means closely adjacent to one side of the body part and for positioning said detector closely adjacent to a generally opposite side of the body part so that near-IR energy emitted by the introducing means is transmitted through said body part and detected by said detector.
Claim 13
Dependent Claim
23 words
An analysis instrument of claim 11 wherein the positioning means positions the introducing means and the detector on opposite sides of a finger.
Claim 14
Dependent Claim
30 words
An analysis instrument of claim 12 further including means for measuring the thickness of the body part and for providing a signal indicative of the thickness of the body part.
Claim 15
Dependent Claim
17 words
An analysis instrument of claim 13 wherein said means for providing a signal comprises a variable resistor.
Claim 16
Dependent Claim
17 words
An analysis instrument of claim 11 wherein said introducing means comprises at least one infrared emitting diode.
Claim 17
Dependent Claim
18 words
An analysis instrument of claim 11 wherein said introducing means provides a bandwidth centered on about 980 nanometers.
Claim 18
Dependent Claim
34 words
An analysis instrument of claim 11 wherein said introducing means includes a near infrared source and a filter for selectively transmitting near-infrared energy which filter is disposed between said source and said body part.
Claim 19
Dependent Claim
25 words
An analysis instrument of claim 17 for blood glucose measurement wherein said filter selectively transmits near-infrared energy of between about 600 and about 1100 nanometers.
Claim 20
Dependent Claim
28 words
The analysis instrument of claim 11 further including at least one filter for selectively transmitting near-infrared energy, which filter is disposed between the detector and said body part.
Claim 21
Dependent Claim
25 words
An analysis instrument of claim 19 for blood glucose measurement wherein said filter selectively transmits near-infrared energy of between about 600 and about 1100 nanometers.
Claim 22
Dependent Claim
23 words
The method of claim 21 wherein near infrared energy centered on about 980 nanometers is introduced into the blood within said body part.
Claim 23
Dependent Claim
21 words
The analysis instrument of claim 1 wherein said introducing means provides at least one wavelength pair centered on about 980 nanometers.
Claim 24
Dependent Claim
73 words
The analysis instrument of claim 1 wherein the signal processing means processes the signal according to the formula C=K.sub.0 +K.sub.1 [log 1/I.sub.G -log 1/I.sub.H ] wherein C is a concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of [log 1/I.sub.G -log 1/I.sub.H ] and log 1/I G and log 1/I H each represent an optical density value a corresponding wavelengths G and H.
Claim 25
Dependent Claim
83 words
The analysis instrument of claim 1 wherein the signal processing means processes the signal according to the formula C=K.sub.0 +K.sub.1 [log 1/I.sub.A -2*log 1/I.sub.B +log 1/I.sub.C ] wherein C is a concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of [log 1/I.sub.A -2*log 1/I.sub.B +log 1/I.sub.C ] and log 1/I A , log 1/I B , and log 1/I C each represent an optical density value at corresponding wavelengths A, B and C.
Claim 26
Dependent Claim
73 words
The analysis instrument of claim 1 wherein the signal processing means processes the signal according to the formula ##EQU2## wherein C is a concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of ##EQU3## and log 1/I G , log 1/I H , log 1/I I and log 1/I J each represent an optical density value at corresponding wavelengths G, H, I and J.
Claim 27
Dependent Claim
83 words
The analysis instrument of claim 1 wherein the signal processing means processes the signal according to the formula ##EQU4## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of ##EQU5## and log 1/I A , log 1/I B , log 1/I C , log 1/I D , log 1/I E , and log 1/I F each represent an optical density value at corresponding wavelengths A, B, C, D, E and F.
Claim 28
Dependent Claim
95 words
A non-invasive method for quantitatively analyzing blood glucose in blood of a subject, comprising: (a) introducing at least one pair of wavelengths of near-infrared energy into blood within a body part of the subject, said pair being centered on a wavelength within the range of about 600 to 1100 nanometers; (b) detecting near-infrared energy emerging from the subject with a detector which provides a signal upon detecting energy emerging from the subject, and (c) processing the signal to provide a second signal indicative of the amount of glucose present in the blood of the subject.
Claim 29
Dependent Claim
95 words
A non-invasive method for quantitatively analyzing blood glucose in blood of a subject, comprising: (a) introducing at least one pair of wavelengths of near-infrared energy into blood within a body part of the subject, said pair being centered on a wavelength within the range of about 600 to 1100 nanometers; (b) detecting near-infrared energy emerging from the subject with a detector which provides a signal upon detecting energy emerging from the subject, and (c) processing the signal to provide a second signal indicative of the amount of glucose present in the blood of the subject.
Claim 30
Dependent Claim
30 words
The method of claim 27 wherein at least one pair of wavelengths of near infra-red energy centered on about 980 nanometers is introduced into the blood within said body part.
Claim 31
Dependent Claim
69 words
The method of claim 27 wherein the signal is processed according to the formula C=K.sub.0 +K.sub.1 [log 1/I.sub.g -log 1/I.sub.H ] wherein C is a concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of [log 1/I.sub.G -log 1/I.sub.H ] and log 1/I G and log 1/I H each represent an optical density value at corresponding wavelengths G and H.
Claim 32
Dependent Claim
81 words
The method of claim 27 wherein the signal processing means processes the signal according to the formula C=K.sub.0 +K.sub.1 [log 1/I.sub.A -2*log 1/I.sub.B +log 1/I.sub.C ] wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of [log 1/I.sub.A -2*log 1/I.sub.B +log 1/I.sub.C ] and log 1/I A , log 1/I B , and log 1/I C each represent an optical density value at corresponding wavelengths A, B and C.
Claim 33
Dependent Claim
71 words
The method of claim 27 wherein the signal processing means processes the signal according to the formula ##EQU6## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of ##EQU7## and log 1/I G , log 1/I H , log 1/I I and log 1/I J each represent an optical density value at corresponding wavelengths G, H, I and J.
Claim 34
Dependent Claim
82 words
The method of claim 27 wherein the signal processing means processes the signal according to the formula ##EQU8## wherein C is concentration of glucose present in the blood, K 0 is an intercept constant, K 1 is line slope of ##EQU9## and log 1/I A , log 1/I B , log 1/I C , log 1/I D , log 1/I E , and log 1/I F each represent an optical density value at corresponding wavelengths A, B, C, D, E and F.
References Cited (Backward Citations)
GB823832A
Cited
US3344702A
Cited
US3154625A
Cited
US3396280A
Cited
US3463142A
Cited
US3638648A
Cited
US3734631A
Cited
SU401892A1
Cited
US3776642A
Cited
US4037970A
Cited
US3861788A
Cited
US3910701A
Cited
US3877818A
Cited
US3958560A
Cited
US4029420A
Cited
US4095105A
Cited
US4171909A
Cited
US4193116A
Cited
US4226540A
Cited
US4510938A
Cited
US4380240A
Cited
US4207466A
Cited
US4247773B1
Cited
US4247773A
Cited
US4439037A
Cited
US4281248A
Cited
US4286327A
Cited
US4341473A
Cited
US4310763A
Cited
US4515165A
Cited
US4436207A
Cited
US4404642A
Cited
US4466076A
Cited
US4379233A
Cited
US4447725A
Cited
US4442844A
Cited
US4484819A
Cited
US4621643A
Cited
US4480706A
Cited
US4487278A
Cited
US4608990A
Cited
US4768516A
Cited
US4570638A
Cited
US4627008A
Cited
EP0160768B1
Cited
US4633087A
Cited
US4692620A
Cited
DE3541165A1
Cited
US4761552A
Cited
US4734584A
Cited
US4801804A
Cited
US4863530A
Cited
US4798955A
Cited
US4882492A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-01 | 1994-12-31 | 1995-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-01 | 1998-12-31 | 1999-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-01 | 2002-12-31 | 2003-07-02 | $7700.00 | Window Closed / Lapsed |