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US5342785A
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Method for determining pyrogen content
Assignee: Tanabe Pharma Corp
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Filing: 1993-10-26
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Granted: 1994-08-30
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Expires: 2013-10-26
Abstract
Abstract A method for determination of a pyrogen content which comprises bringing a specimen into contact with an adsorbent composed of a nitrogen-containing heterocyclic compound bonded to a water-insoluble carrier directly or through a spacer, and after or without eluting the pyrogen adsorbed on the adsorbent, determining the content of the adsorbed pyrogen by the Limulus method.
Inventors
- 👤 Tetsuya Tosa
- 👤 Tadashi Sato
- 👤 Taizo Watanabe
- 👤 Satoshi Minobe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:09
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/579; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
69 words
A method for the detection of the presence of a pyrogen in a specimen, which comprises bringing the specimen into contact with an adsorbent composed of a nitrogen-containing heterocyclic compound said compound being histidine, or adenine, bonded to agarose through hexamethylenediamine, and, without eluting the pyrogen adsorbed ont he adsorbent, detecting whetehr there is any adsorbed pyrogen on the adsorbent by directly subjecting the adsorbent to a Limulus test.
Claim 2
Independent Claim
69 words
A method for the detection of the presence of a pyrogen in a specimen, which comprises bringing the specimen into contact with an adsorbent composed of a nitrogen-containing heterocyclic compound said compound being histidine, or adenine, bonded to agarose through hexamethylenediamine, and, without eluting the pyrogen adsorbed ont he adsorbent, detecting whetehr there is any adsorbed pyrogen on the adsorbent by directly subjecting the adsorbent to a Limulus test.
Claim 3
Dependent Claim
17 words
A method according to claim 1, wherein the specimen is a water-containing solution or an aqueous solution.
Claim 4
Dependent Claim
22 words
A method according to claim 1, wherein the adsorbent is the nitrogen-containing heterocyclic compound bonded to the agarose through hexamethylenediamine by epichlorohydrin.
Claim 5
Dependent Claim
16 words
A method according to claim 1, wherein the adsorbent is histidine bonded to agarose through hexamethylenediamine.
Claim 6
Dependent Claim
16 words
A method according to claim 1, wherein the adsorbent is adenine bonded to agarose through hexamethylenediamine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-29 | 1998-02-28 | 1998-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-29 | 2002-02-28 | 2002-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-29 | 2006-02-28 | 2006-08-30 | $7700.00 | Window Closed / Lapsed |