US4276050A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for systemic endotoxin detection
Assignee: Abbott Laboratories
•
Filing: 1980-01-10
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Granted: 1981-06-30
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Expires: 2000-01-10
Abstract
Abstract A method for detecting endotoxins in body fluids comprising: unmasking endotoxins in the body fluids; separating the unmasked endotoxins from the body fluids by affinity chromatography; and detecting the endotoxins. This method is particularly useful for early detection of life threatening systemic Gram-negative infections.
Inventors
- 👤 Joseph R. Firca
- 👤 Jon A. Rudbach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:27
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/579; Y; Y10; Y10S; Y10S436/00; Y10S436/825
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
33 words
A method for detecting endotoxins in body fluids comprising: (a) unmasking endotoxins in the body fluid; (b) separating the unmasked endotoxins from the body fluid by affinity chromatography; and (c) detecting the endotoxins.
Claim 2
Independent Claim
33 words
A method for detecting endotoxins in body fluids comprising: (a) unmasking endotoxins in the body fluid; (b) separating the unmasked endotoxins from the body fluid by affinity chromatography; and (c) detecting the endotoxins.
Claim 3
Dependent Claim
18 words
A method, according to claim 1, wherein the endotoxin is detected while bound to an affinity chromatography matrix.
Claim 4
Dependent Claim
18 words
A method, according to claim 1, wherein the endotoxin is detected after elution from an affinity chromatography matrix.
Claim 5
Dependent Claim
19 words
A method, according to claim 3, wherein the endotoxin is detected by the Limulus amoebocyte lysate test for endotoxins.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-06-29 | 1984-12-29 | 1985-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-06-29 | 1988-12-29 | 1989-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-06-29 | 1992-12-29 | 1993-06-30 | $7700.00 | Window Closed / Lapsed |