Patent US5292501A successfully refreshed from Google Patents.
US5292501A
Expired / Lapsed
US
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Use of a carboxy-substituted polymer to inhibit plaque formation without tooth staining
Assignee: Individual
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Filing: 1993-04-26
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Granted: 1994-03-08
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Expires: 2013-04-26
Abstract
Abstract The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR1## or the salts thereof, wherein R is a C 1 -C 8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition. This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface. The application does not stain the teeth on which it is made.
Inventors
- 👤 Charles R. Degenhardt
- 👤 Barbara A. Kozikowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:25
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/81; A61K8/8135; A61Q; A61Q11/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
76 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR6## or the salts thereof, wherein R is a C 2 -C 8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
76 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR6## or the salts thereof, wherein R is a C 2 -C 8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
27 words
An oral composition according to claim 1 wherein the mass average molecular weight of the carboxy-substituted active agent in (a) ranges from about 2,000 to about 500,000.
Claim 4
Dependent Claim
54 words
An oral composition according to claim 1 wherein R is a C 2 -C 4 straight-chain aliphatic group, n is in the range of from 0 to about 1,000, m is in the range of from about 25 to about 1,5000, and p is in the range of from about 2 to about 5.
Claim 5
Dependent Claim
30 words
An oral composition according to claim 2 wherein the mass average molecular weight of the active agent in (a) is in the range of from about 5,000 to about 250,000.
Claim 6
Dependent Claim
23 words
An oral composition according to claim 3 which comprises from about 0.1% to about 10.0% by weight of the carboxy-substituted active agent (a).
Claim 7
Dependent Claim
23 words
An oral composition according to claim 4 which comprises from about 1.0% to about 10.0% by weight of the carboxy-substituted active agent (a).
Claim 8
Dependent Claim
23 words
An oral composition according to claim 6 which comprises from about 1.0% to about 6.0% by weight of the carboxy-substituted active agent (a).
Claim 9
Dependent Claim
15 words
An oral composition according to claim 6 wherein the pharmaceutically acceptable carrier is a toothpaste.
Claim 10
Dependent Claim
14 words
An oral composition according to claim 8 which also contains a silica dental abrasive.
Claim 11
Dependent Claim
15 words
An oral composition according to claim 6 wherein the pharmaceutically acceptable carrier is a mouthwash.
Claim 12
Dependent Claim
17 words
An oral composition according to claim 2 wherein the pharmaceutically acceptable carrier is a topical dental gel.
Claim 13
Independent Claim
87 words
A method of inhibiting plaque formation on tooth surfaces in the oral cavity compromising applying to the oral cavity a safe and effective amount, in the unit dosage form, of a carboxy-substituted polymer active agent having the formula ##STR7## or the salts thereof, wherein R is a C 2-8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10.
Claim 14
Independent Claim
87 words
A method of inhibiting plaque formation on tooth surfaces in the oral cavity compromising applying to the oral cavity a safe and effective amount, in the unit dosage form, of a carboxy-substituted polymer active agent having the formula ##STR7## or the salts thereof, wherein R is a C 2-8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10.
Claim 15
Dependent Claim
24 words
A method according to claim 12 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a toothpaste.
Claim 16
Dependent Claim
24 words
A method according to claim 12 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a mouthwash.
Claim 17
Dependent Claim
25 words
A method according to claim 12 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a dental gel.
Claim 18
Dependent Claim
73 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR8## or the salts thereof, wherein R is CH 3 , n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is 1 or in the range of from 3 to about 10; and (b) a pharmaceutically acceptable carrier.
Claim 19
Dependent Claim
73 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR8## or the salts thereof, wherein R is CH 3 , n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is 1 or in the range of from 3 to about 10; and (b) a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-07 | 1997-09-06 | 1998-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-07 | 2001-09-06 | 2002-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-07 | 2005-09-06 | 2006-03-08 | $7700.00 | Window Closed / Lapsed |