US5093170A
Expired / Lapsed
US
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Use of a carboxy-substituted polymer to inhibit plaque formation without tooth staining
Assignee: Procter and Gamble Co
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Filing: 1990-06-25
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Granted: 1992-03-03
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Expires: 2010-06-25
Abstract
Abstract The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula <IMAGE> or the salts thereof, wherein R is a C1-C8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition. This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface. The application does not stain the teeth on which it is made.
Inventors
- 👤 Charles R. Degenhardt
- 👤 Barbara A. Kozikowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:43
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/81; A61K8/8135; A61Q; A61Q11/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
55 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR6## or the salts thereof, wherein n is in the range of from 0 to about 2,000 and m is in the range of from about 10 to about 2,000; and (b) a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
55 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR6## or the salts thereof, wherein n is in the range of from 0 to about 2,000 and m is in the range of from about 10 to about 2,000; and (b) a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
27 words
An oral composition according to claim 1 wherein the mass average molecular weight of the carboxy-substituted active agent in (a) ranges from about 2,000 to about 500,000.
Claim 4
Dependent Claim
54 words
An oral composition according to claim 2 wherein R is a C 1 -C 4 straight-chain aliphatic group, n is in the range of from 0 to about 1,000, m is in the range of from about 25 to about 1,500, and p is in the range of from about 2 to about 5.
Claim 5
Dependent Claim
30 words
An oral composition according to claim 2 wherein the mass average molecular weight of the active agent in (a) is in the range of from about 5,000 to about 250,000.
Claim 6
Dependent Claim
40 words
An oral composition according to claim 3 wherein R is a methyl group, n is in the range of from 0 to about 500, m is in the range of from about 50 to about 1,000, and p is 2.
Claim 7
Dependent Claim
23 words
An oral composition according to claim 3 which comprises from about 0.1% to about 10.0% by weight of the carboxy-substituted active agent (a).
Claim 8
Dependent Claim
23 words
An oral composition according to claim 5 which comprises from about 1.0% to about 10.0% by weight of the carboxy-substituted active agent (a).
Claim 9
Dependent Claim
23 words
An oral composition according to claim 7 which comprises from about 1.0% to about 6.0% by weight of the carboxy-substituted active agent (a).
Claim 10
Dependent Claim
20 words
An oral composition according to claim 6 which additionally contains a safe and effective amount of a fluoride ion source.
Claim 11
Dependent Claim
28 words
An oral composition according to claim 9 wherein the fluoride ion source is sodium fluoride present at a concentration ranging from about 0.005% to about 2.0% by weight.
Claim 12
Dependent Claim
15 words
An oral composition according to claim 10 wherein the pharmaceutically acceptable carrier is a toothpaste.
Claim 13
Dependent Claim
14 words
An oral composition according to claim 11 which also contains a silica dental abrasive.
Claim 14
Dependent Claim
15 words
An oral composition according to claim 10 wherein the pharmaceutically acceptable carrier is a mouthwash.
Claim 15
Dependent Claim
55 words
An oral composition comprising: (a) a safe and effective amount of a succinylated poly(vinyl alcohol) active agent having the formula ##STR7## or the salts thereof, wherein n is in the range of from 0 to about 500, and m is in the range of rom about 50 to about 1,000; and (b) a pharmaceutically-acceptable carrier.
Claim 16
Dependent Claim
55 words
An oral composition comprising: (a) a safe and effective amount of a succinylated poly(vinyl alcohol) active agent having the formula ##STR7## or the salts thereof, wherein n is in the range of from 0 to about 500, and m is in the range of rom about 50 to about 1,000; and (b) a pharmaceutically-acceptable carrier.
Claim 17
Independent Claim
66 words
A method of inhibiting plaque formation on tooth surfaces in the oral cavity comprising applying to the oral cavity a safe and effective amount, in unit dosage form , of a carboxy-substituted polymer active agent having the formula ##STR8## or the salts thereof, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000.
Claim 18
Independent Claim
66 words
A method of inhibiting plaque formation on tooth surfaces in the oral cavity comprising applying to the oral cavity a safe and effective amount, in unit dosage form , of a carboxy-substituted polymer active agent having the formula ##STR8## or the salts thereof, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000.
Claim 19
Dependent Claim
24 words
A method according to claim 15 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a toothpaste.
Claim 20
Dependent Claim
24 words
A method according to claim 15 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a mouthwash.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
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