US5292501A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of a carboxy-substituted polymer to inhibit plaque formation without tooth staining
Assignee: Individual
•
Filing: 1993-04-26
•
Granted: 1994-03-08
•
Expires: 2013-04-26
Abstract
Abstract The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR1## or the salts thereof, wherein R is a C 1 -C 8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition. This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface. The application does not stain the teeth on which it is made.
Inventors
- 👤 Charles R. Degenhardt
- 👤 Barbara A. Kozikowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:44
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/81; A61K8/8135; A61Q; A61Q11/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
76 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR6## or the salts thereof, wherein R is a C 2 -C 8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
76 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR6## or the salts thereof, wherein R is a C 2 -C 8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
27 words
An oral composition according to claim 1 wherein the mass average molecular weight of the carboxy-substituted active agent in (a) ranges from about 2,000 to about 500,000.
Claim 4
Dependent Claim
54 words
An oral composition according to claim 1 wherein R is a C 2 -C 4 straight-chain aliphatic group, n is in the range of from 0 to about 1,000, m is in the range of from about 25 to about 1,5000, and p is in the range of from about 2 to about 5.
Claim 5
Dependent Claim
30 words
An oral composition according to claim 2 wherein the mass average molecular weight of the active agent in (a) is in the range of from about 5,000 to about 250,000.
Claim 6
Dependent Claim
23 words
An oral composition according to claim 3 which comprises from about 0.1% to about 10.0% by weight of the carboxy-substituted active agent (a).
Claim 7
Dependent Claim
23 words
An oral composition according to claim 4 which comprises from about 1.0% to about 10.0% by weight of the carboxy-substituted active agent (a).
Claim 8
Dependent Claim
23 words
An oral composition according to claim 6 which comprises from about 1.0% to about 6.0% by weight of the carboxy-substituted active agent (a).
Claim 9
Dependent Claim
15 words
An oral composition according to claim 6 wherein the pharmaceutically acceptable carrier is a toothpaste.
Claim 10
Dependent Claim
14 words
An oral composition according to claim 8 which also contains a silica dental abrasive.
Claim 11
Dependent Claim
15 words
An oral composition according to claim 6 wherein the pharmaceutically acceptable carrier is a mouthwash.
Claim 12
Dependent Claim
17 words
An oral composition according to claim 2 wherein the pharmaceutically acceptable carrier is a topical dental gel.
Claim 13
Independent Claim
87 words
A method of inhibiting plaque formation on tooth surfaces in the oral cavity compromising applying to the oral cavity a safe and effective amount, in the unit dosage form, of a carboxy-substituted polymer active agent having the formula ##STR7## or the salts thereof, wherein R is a C 2-8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10.
Claim 14
Independent Claim
87 words
A method of inhibiting plaque formation on tooth surfaces in the oral cavity compromising applying to the oral cavity a safe and effective amount, in the unit dosage form, of a carboxy-substituted polymer active agent having the formula ##STR7## or the salts thereof, wherein R is a C 2-8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10.
Claim 15
Dependent Claim
24 words
A method according to claim 12 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a toothpaste.
Claim 16
Dependent Claim
24 words
A method according to claim 12 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a mouthwash.
Claim 17
Dependent Claim
25 words
A method according to claim 12 wherein the carboxy-substituted polymer active agent is applied by applying a composition in the form of a dental gel.
Claim 18
Dependent Claim
73 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR8## or the salts thereof, wherein R is CH 3 , n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is 1 or in the range of from 3 to about 10; and (b) a pharmaceutically acceptable carrier.
Claim 19
Dependent Claim
73 words
An oral composition comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR8## or the salts thereof, wherein R is CH 3 , n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is 1 or in the range of from 3 to about 10; and (b) a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
US3429963A
Cited
US3810468A
Cited
US3939261A
Cited
US4089830A
Cited
US4138477A
Cited
US4118474A
Cited
US4118473A
Cited
US4224309A
Cited
US4362713A
Cited
US4375461A
Cited
US4615881A
Cited
US4451452A
Cited
US4428930A
Cited
GB2151478A
Cited
JPS60142923A
Cited
US4816245A
Cited
US4661341A
Cited
WO1986002831A1
Cited
US4627977A
Cited
US4775525A
Cited
EP0241179A1
Cited
US4759925A
Cited
US4847070A
Cited
US4877603A
Cited
US4855128A
Cited
US5094840A
Cited
US5093170A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-07 | 1997-09-06 | 1998-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-07 | 2001-09-06 | 2002-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-07 | 2005-09-06 | 2006-03-08 | $7700.00 | Window Closed / Lapsed |