US5236704A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release formulation
Assignee: Sumitomo Pharma Co Ltd
•
Filing: 1989-01-27
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Granted: 1993-08-17
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Expires: 2009-01-27
Abstract
Abstract A controlled release formulation which comprises an organic acidic compound or an acid anhydride or ester capable of generating one of the organic acidic compounds through hydrolysis together with an active ingredient and collagen as a carrier, said formulation being capable of exhibiting a predetermined release profile of the active ingredient. A process for producing said formulation is also provided.
Inventors
- 👤 Keiji Fujioka
- 👤 Shigeji Sato
- 👤 Nobuhiko Tamura
- 👤 Yoshihiro Takada
- 👤 Yoshio Sasaki
- 👤 Miho Maeda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063; A61K47/00; A61K47/06; A61K47/08; A61K47/12; A61K47/16; A61K47/18; A61K47/183; A61K47/30; A61K47/42; A61K9/2013
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
99 words
A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen as a carrier and a bioactive protein or peptide as an active ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
Claim 2
Independent Claim
99 words
A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen as a carrier and a bioactive protein or peptide as an active ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
Claim 3
Dependent Claim
10 words
The method of claim 1, wherein said collagen is atelocollagen.
Claim 4
Dependent Claim
25 words
The method of claim 1, wherein the bioactive proteins and peptides are selected from cytokines, hormones, hormone-releasing factors, hormone release-inhibiting factors, growth factors and enzymes.
Claim 5
Dependent Claim
17 words
The method of claim 3, wherein the hormone-releasing factors are growth hormone-releasing factors and luteinizing hormone-releasing factor.
Claim 6
Dependent Claim
16 words
The method of claim 3, wherein the cytokines are selected from intereleukins, interferons, and colony-stimulating factors.
Claim 7
Dependent Claim
13 words
The method of claim 3, wherein the hormones are growth hormone and calctionin.
Claim 8
Dependent Claim
12 words
The method of claim 3, wherein the hormone release-inhibiting factor is somatostatine.
Claim 9
Dependent Claim
34 words
The method of claim 3, wherein growth factors are selected from the group consisting of somatomedin, nerve growth factor, epidermal growth factor, transforming growth factor, fibroblast growth factor, erythropoietin (EPO) and platelet-derived growth factor.
Claim 10
Dependent Claim
14 words
The method of claim 3, wherein the enzymes are tissue plasminogen activator and urokinase.
Claim 11
Dependent Claim
25 words
The method of claim 1, wherein the amino acid is a member selected from the group consisting of aspartic acid, glutamic acid, glycine, and alanine.
Claim 12
Independent Claim
92 words
A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen and a hormone releasing factor ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
Claim 13
Independent Claim
92 words
A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen and a hormone releasing factor ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
Claim 14
Dependent Claim
25 words
The method of claim 11, wherein said amino acid is a member selected from the group consisting of aspartic acid, glutamic acid, glycine, and alanine.
Claim 15
Dependent Claim
10 words
The method of claim 11, wherein said collagen is atelocollagen.
Claim 16
Dependent Claim
11 words
The method of claim 11, wherein said amino acid is glycine.
Claim 17
Dependent Claim
11 words
The method of claim 13, wherein said amino acid is glycine.
Claim 18
Dependent Claim
15 words
The method of claim 11, wherein said hormone releasing factor is growth hormone releasing factor.
Claim 19
Dependent Claim
15 words
The method of claim 12, wherein said hormone releasing factor is growth hormone releasing factor.
Claim 20
Dependent Claim
15 words
The method of claim 13, wherein said hormone releasing factor is growth hormone releasing factor.
Claim 21
Dependent Claim
15 words
The method of claim 14, wherein said hormone releasing factor is growth hormone releasing factor.
Claim 22
Dependent Claim
15 words
The method of claim 15, wherein said hormone releasing factor is growth hormone releasing factor.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-16 | 1997-02-15 | 1997-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-16 | 2001-02-15 | 2001-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-16 | 2005-02-15 | 2005-08-17 | $7700.00 | Window Closed / Lapsed |