EP0140255A2
Expired / Lapsed
EP
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Sustained-release injections
Assignee: Sumitomo Pharma Co Ltd
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Filing: 1984-10-12
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Granted: —
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Expires: 2004-10-12
Abstract
Abstract A sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, polysaccharides and synthetic high molecular compounds, preferably collagen, atelocollagen, gelatin, and a mixture thereof) in a viscous solvent for injection (e.g. vegetable oils, polyethylene glycol, propylene glycol, silicone oil, and medium-chain fatty acid triglycerides). The sustained-release injection can release the active ingredient at an effective level for a long period of time when injected.
Inventors
- 👤 Yoshiya Yamahira
- 👤 Keiji Fujioka
- 👤 Shigeji Sato
- 👤 Noboru Yoshida
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:15
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/212; A61K9/00; A61K9/10; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1658
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
26 words
A sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier in a viscous solvent for injection.
Claim 2
Dependent Claim
26 words
A sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier in a viscous solvent for injection.
Claim 3
Dependent Claim
26 words
The preparation according to claim 1, wherein the biodegradable carrier is a member selected from the group consisting of proteins, polysaccharides and synthetic high molecular compounds.
Claim 4
Dependent Claim
26 words
The preparation according to claim 1, wherein the biodegradable carrier is a member selected from the group consisting of collagen, atelocollagen, gelatin, and a mixture thereof.
Claim 5
Dependent Claim
36 words
The preparation according to claim 1 or 3, wherein the viscous solvent for injection is a member selected from the group consisting of vegetable oils, polyethylene glycol, propylene glycol, silicone oil, and medium-chain fatty acid triglycerides.
Claim 6
Dependent Claim
43 words
The preparation according to claim 1, wherein the viscous solvent for injection is a member selected from the group consisting of peanut oil, cotton seed oil, sesame oil, castor oil, olive oil, corn oil, and iodinated poppy seed oil fatty acids ethyl esters.
Claim 7
Dependent Claim
13 words
The preparation according to claim 1, wherein the viscous solvent is sesame oil.
Claim 8
Dependent Claim
56 words
The preparation according to claim 1, wherein the active ingredient is incorporated into the biodegradable carrier in the following state: (i) the active ingredient is chemically bound to the carrier matrix, (ii) The active ingredient is bound to the carrier matrix by intermolecular action, or (iii) The active ingredient is physically embraced within the carrier matrix.
Claim 9
Dependent Claim
39 words
The preparation according to claim 1, wherein active ingredient is a member selected from the group consisting of indomethacin, prostaglandins, prostacyclines, bio-hormones, tespamin, adriamycin, bleomycins, mitomycin, interferon, interleukin, tumor necrosis factor, and 4-carbamoyl-imidazolium-5-oleate or a salt or hydrate thereof.
Claim 10
Dependent Claim
25 words
The preparation according to claim 1, wherein the active ingredient is a member selected from the group consisting of interferon, interleukin and tumor necrosis factor.
Claim 11
Dependent Claim
12 words
The preparation according to claim 1, wherein the active ingredient is interferon.
Claim 12
Independent Claim
47 words
A method for the preparation of a sustained-release injection preparation, which comprises mixing an active ingredient and a pharmaceutically acceptable biodegradable carrier to incorporate the active ingredient in a carrier matrix, pulverizing the carrier matrix, and then suspending the pulverized product in a viscous solvent for injection.
Claim 13
Independent Claim
47 words
A method for the preparation of a sustained-release injection preparation, which comprises mixing an active ingredient and a pharmaceutically acceptable biodegradable carrier to incorporate the active ingredient in a carrier matrix, pulverizing the carrier matrix, and then suspending the pulverized product in a viscous solvent for injection.
Claim 14
Dependent Claim
32 words
The method according to claim 11, wherein the viscous solvent is a member selected from the group consisting of vegetable oils, polyethylene glycol, propylene glycol, silicone oil, and medium-chain fatty acid triglycerides.
Claim 15
Dependent Claim
41 words
The method according to claim 11, wherein the viscous solvent is a member selected from the group consisting of peanut oil, cotton seed oil, sesame oil, castor oil, olive oil, corn oil, and iodinated poppy seed oil fatty acids ethyl esters.
Claim 16
Dependent Claim
13 words
The method according to claim 11, wherein the viscous solvent is sesame oil.
References Cited (Backward Citations)
No citation records indexed.
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