Patent US5236456A successfully refreshed from Google Patents.
US5236456A
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Osteogenic composition and implant containing same
Assignee: Warsaw Orthopedic Inc
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Filing: 1991-01-17
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Granted: 1993-08-17
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Expires: 2011-01-17
Abstract
Abstract An osteogenic composition is obtained from demineralized bone tissue.
Inventors
- 👤 Robert K. O'Leary
- 👤 Annamarie B. Prewett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:29
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61K; A61K35/00; A61K35/12; A61K35/32; A61L24/00; A61L24/0005; A61L24/001; A61L24/0015; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61L27/50; A61L27/54; A61F2/32; A61F2/46; A61F2/4644; A61F2/28; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30059; A61F2310/00; A61F2310/00389; A61F2310/00958; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2430/00; A61L2430/02; A61L2430/40; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
97 words
An osteogenic composition resulting from the process comprising: a) demineralizing bone tissue to provide an acid insoluble demineralized bone matrix from which at least a substantial portion of original calcium content of the bone tissue has been removed, said matrix being made up of collagenous residue and non-collagenous proteinaceous matter; b) subjecting the demineralized bone matrix to acid-promoted cleavage of intra-molecular bonds in collagen molecules and inter-molecular bonds between collagen molecules to provide a cleavage product; and, c) heating the cleavage product to provide a liquid surface-adherent osteogenic composition which is acid soluble upon said heating thereof.
Claim 2
Dependent Claim
97 words
An osteogenic composition resulting from the process comprising: a) demineralizing bone tissue to provide an acid insoluble demineralized bone matrix from which at least a substantial portion of original calcium content of the bone tissue has been removed, said matrix being made up of collagenous residue and non-collagenous proteinaceous matter; b) subjecting the demineralized bone matrix to acid-promoted cleavage of intra-molecular bonds in collagen molecules and inter-molecular bonds between collagen molecules to provide a cleavage product; and, c) heating the cleavage product to provide a liquid surface-adherent osteogenic composition which is acid soluble upon said heating thereof.
Claim 3
Dependent Claim
12 words
The osteogenic composition of claim 1 which is in viscous liquid form.
Claim 4
Dependent Claim
19 words
The osteogenic composition of claim 1 wherein in step (b), the demineralized bone matrix is converted to a pulp.
Claim 5
Dependent Claim
20 words
The osteogenic composition of claim 1 wherein the demineralized bone matrix contains not greater than about 10 weight percent calcium.
Claim 6
Dependent Claim
20 words
The osteogenic composition of claim 4 wherein the demineralized bone matrix contains not greater than about 1 weight percent calcium.
Claim 7
Dependent Claim
20 words
The osteogenic composition of claim 5 wherein the demineralized bone matrix contains not greater than about 0.5 weight percent calcium.
Claim 8
Dependent Claim
24 words
The osteogenic composition of claim 1 wherein said heating step (c) is carried out at temperature of from about 30° to about 75° C.
Claim 9
Dependent Claim
25 words
The osteogenic composition of claim 7 wherein said heating step (c) is carried out at a temperature of from about 35° to about 60° C.
Claim 10
Dependent Claim
25 words
The osteogenic composition of claim 8 wherein said heating step (c) is carried out at a temperature of from about 40° to about 55° C.
Claim 11
Dependent Claim
26 words
The osteogenic composition of claim 1 wherein said heating step (c) is carried out for a period of from about 5 minutes to about 10 hours.
Claim 12
Dependent Claim
10 words
The osteogenic composition of claim 1 containing demineralized bone powder.
Claim 13
Dependent Claim
80 words
The osteogenic composition of claim 1 containing at least one ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, inorganic element, hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, polymeric drug carrier, collagen lattice, antigenic agent, cytoskeletal agent, cartilage fragment, living cell, natural extract, tissue transplant, bioadhesive biologically active component, mesenchymal agent, bone digester, antitumor agent, cellular attractant, cellular attachment agent, immunosuppressant, nucleic acid and penetration enhancer.
Claim 14
Dependent Claim
16 words
A surgical implant device having a surface with the osteogenic composition of claim 1 adhered thereto.
Claim 15
Dependent Claim
47 words
The osteogenic composition of claim 1, additionally comprising the step of: d) treating the liquid composition produced in step (c) to obtain the osteogenic composition in solid form by adding organic solvent to the liquid composition, whereby the osteogenic composition precipitates out of solution in solid form.
Claim 16
Dependent Claim
28 words
The osteogenic composition of claim 14, additionally comprising the step of: titrating the liquid composition produced in step (c), before carrying out step (d), to remove excess acid.
Claim 17
Dependent Claim
30 words
The osteogenic composition of claim 14, additionally comprising the step of: further dissolving the precipitated solid composition from step (d) in solution, whereby the osteogenic composition is in injectable form.
Claim 18
Dependent Claim
68 words
The osteogenic composition of claim 1, additionally comprising the step of: d) treating the liquid composition produced in step (c) to obtain the osteogenic composition in solid form, by first titrating the liquid composition produced in step (c) to remove excess acid, then placing the titrated composition in a dialysis bag and then carrying out dialysis, whereby the osteogenic composition remains in the dialysis bag in solid form.
Claim 19
Dependent Claim
29 words
The osteogenic composition of claim 17, additionally comprising the step of: further dissolving the osteogenic composition from step (d) in solution, whereby the osteogenic composition is in injectable form.
Claim 20
Dependent Claim
22 words
The osteogenic composition of claim 1 wherein said acid-promoted cleavage step (b) is carried out simultaneously with said bone demineralizing step (a).
Claim 21
Dependent Claim
24 words
The osteogenic composition of claim 1 wherein said acid-promoted cleavage step (b) is separately carried out after said demineralizing step (a) has been completed.
Claim 22
Dependent Claim
24 words
The osteogenic composition of claim 1 wherein said heating step (c) is carried out simultaneously with or subsequent to said acid-promoted cleavage step (b).
Claim 23
Dependent Claim
8 words
The osteogenic composition of claim 1 containing hydroxyapatite.
Claim 24
Dependent Claim
10 words
The osteogenic composition of claim 1 containing non-demineralized bone powder.
Claim 25
Dependent Claim
23 words
The osteogenic composition of claim 1 containing at least one ingredient selected from the group consisting of bone morphogenic agents and growth factors.
Claim 26
Dependent Claim
36 words
The osteogenic composition of claim 24 containing at least one ingredient selected from the group consisting of platelet derived growth factor, basic fibroblast growth factor, transforming growth factor beta, insulin-like growth factor, and epidermal growth factor.
Claim 27
Dependent Claim
13 words
A surgical implant device having the osteogenic composition of claim 1 incorporated therewithin.
Claim 28
Dependent Claim
34 words
The osteogenic composition of claim 1 wherein the demineralized bone tissue is derived from cortical autogenic, cortical allogeneic, cortical xenogeneic, cancellous autogenic, cancellous allogeneic, cancellous xenogeneic, corticocancellous autogenic, corticocancellous allogeneic or corticocancellous xenogeneic bone.
Claim 29
Dependent Claim
18 words
The osteogenic composition of claim 1 wherein concentration of acid in step (b) is at least about 2.0N.
References Cited (Backward Citations)
US2968593A
Cited
US4516276A
Cited
US4789732A
Cited
US4394370A
Cited
US4472840A
Cited
US4440750A
Cited
US4485097A
Cited
US4581030A
Cited
US4563350A
Cited
US4888366A
Cited
US5053049A
Cited
US4824939A
Cited
EP0321442A2
Cited
WO1989011880A1
Cited
EP0366029A2
Cited
US4975526A
Cited
EP0419275A1
Cited
US5073373A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1996-08-16 | 1997-02-15 | 1997-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-16 | 2001-02-15 | 2001-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-16 | 2005-02-15 | 2005-08-17 | $7700.00 | Window Closed / Lapsed |