US5229127A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives
Assignee: Individual
•
Filing: 1990-12-03
•
Granted: 1993-07-20
•
Expires: 2010-12-03
Abstract
Abstract Quick miosis with 24 hour control of intraocular pressure of patients undergoing extracapsular cataract extraction surgery is achieved by applying to the eyes of the patient during surgery acetylcholine as a first miotic agent and carbachol as a second miotic agent. Acetylcholine provides quick miosis while carbachol enhances the miotic effect while providing post-surgery control of intraocular pressure. The two miotic agents can be dissolved in a common saline carrier. The two agents can be combined in a unit dosage package by disposing acetylcholine in powder form in a first compartment and a solution of carbachol in a second compartment. The combined miotic agent of the invention is especially useful when substances which raise IOP such as viscoelastic agents are used during ocular surgery and/or with sensitive patients who enter the surgery with elevated pressure such as those suffering from glaucoma.
Inventors
- 👤 James W. McKinzie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 18:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; Y; Y10; Y10S; Y10S215/00; Y10S215/03
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
158 words
A method of inducing quick miosis while controlling intraocular pressure in a mammal during ocular surgery comprising the steps of: topically applying a viscoelastic agent to the eye of the mammal during surgery; topically applying to the eye of the mammal during said surgery a composition containing from 0.1 to 5% by weight of a first miotic agent in a pharmacologically acceptable aqueous carrier, said first agent being selected from compounds of the formula: ##STR3## where R and R 1 are lower alkyl groups containing 1 to 5 carbon atoms and X - is an anion; and topically applying to the eye of the mammal during said surgery a composition containing 0.001 to 1.0 percent by weight of a second miotic agent dissolved in pharmacologically acceptable carrier selected from compounds of the formula: ##STR4## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X - is an anion.
Claim 2
Independent Claim
158 words
A method of inducing quick miosis while controlling intraocular pressure in a mammal during ocular surgery comprising the steps of: topically applying a viscoelastic agent to the eye of the mammal during surgery; topically applying to the eye of the mammal during said surgery a composition containing from 0.1 to 5% by weight of a first miotic agent in a pharmacologically acceptable aqueous carrier, said first agent being selected from compounds of the formula: ##STR3## where R and R 1 are lower alkyl groups containing 1 to 5 carbon atoms and X - is an anion; and topically applying to the eye of the mammal during said surgery a composition containing 0.001 to 1.0 percent by weight of a second miotic agent dissolved in pharmacologically acceptable carrier selected from compounds of the formula: ##STR4## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X - is an anion.
Claim 3
Dependent Claim
25 words
A method according to claim 1 in which R and R' are methyl, R 2 is methyl, n is O and X - is chloro.
Claim 4
Dependent Claim
17 words
A method according to claim 2 in which the two agents are applied to the eye sequentially.
Claim 5
Dependent Claim
20 words
A method according to claim 3 in which the first agent is applied to the eye before the second agent.
Claim 6
Dependent Claim
17 words
A method according to claim 2 in which the two agents are applied to the eye simultaneously.
Claim 7
Dependent Claim
23 words
A method according to claim 1 in which both miotic agents are dissolved in a pharmacologically acceptable aqueous saline as a common carrier.
Claim 8
Dependent Claim
13 words
A method according to claim 1 in which the mammal is a human.
Claim 9
Dependent Claim
21 words
A Method according to claim 7 in which the human subject is undergoing extracapsular cataract extraction with intraocular lens implant surgery.
Claim 10
Dependent Claim
15 words
A method according to claim 8 in which the human subject is suffering from glaucoma.
Claim 11
Dependent Claim
14 words
A method according to claim 1 in which said both carries are aqueous carriers.
Claim 12
Dependent Claim
146 words
A unit dosage package containing a combination of a miotic agent capable of achieving quick miosis and an agent for controlling intraocular pressure, comprising: a first sterile compartment containing a unit dosage of a solution comprising 0.001 to 1.0 percent by weight of a first compound of the formula: ##STR5## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X - is an anion; a second sterile compartment containing a unit dosage in dry powder form of a second compound selected from compounds of the formula: ##STR6## where R and R 1 are lower alkyl groups containing 1-5 carbon atoms and X - is an anion; said second compound having a concentration of 0.1 to 5 percent by weight when dissolved in said solution; and means for combining the contents of the first and second compartments.
Claim 13
Dependent Claim
146 words
A unit dosage package containing a combination of a miotic agent capable of achieving quick miosis and an agent for controlling intraocular pressure, comprising: a first sterile compartment containing a unit dosage of a solution comprising 0.001 to 1.0 percent by weight of a first compound of the formula: ##STR5## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X - is an anion; a second sterile compartment containing a unit dosage in dry powder form of a second compound selected from compounds of the formula: ##STR6## where R and R 1 are lower alkyl groups containing 1-5 carbon atoms and X - is an anion; said second compound having a concentration of 0.1 to 5 percent by weight when dissolved in said solution; and means for combining the contents of the first and second compartments.
Claim 14
Dependent Claim
13 words
A package according to claim 11 in which the containers are physically joined.
Claim 15
Dependent Claim
21 words
A package according to claim 12 in which the containers are joined by an elastomer seal penetrable by a hypodermic needle.
Claim 16
Dependent Claim
31 words
A package according to claim 11 in which R and R 1 are methyl, X - is chloro and R 2 is methyl, n is O and X - is chloro.
Claim 17
Dependent Claim
28 words
A unit dosage package according to claim 11 in which the package is a univial containing an elastomer plug dividing the univial into said first and second compartments.
Claim 18
Dependent Claim
54 words
A topical, ophthalmic, pharmaceutical composition for achieving quick miosis and for controlling intraocular pressure, comprising: 0.1 to 5 percent by weight of a first compound selected from compounds of the formula: ##STR7## where R and R 1 are lower alkyl groups containing 1 to 5 carbon atoms and X - is an anion; and
Claim 19
Dependent Claim
54 words
A topical, ophthalmic, pharmaceutical composition for achieving quick miosis and for controlling intraocular pressure, comprising: 0.1 to 5 percent by weight of a first compound selected from compounds of the formula: ##STR7## where R and R 1 are lower alkyl groups containing 1 to 5 carbon atoms and X - is an anion; and
Claim 20
Dependent Claim
46 words
001 to 1.0 percent by weight of a second compound selected from compounds of the formula: ##STR8## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X - is an anion; and a pharmacologically acceptable carrier.
Claim 21
Dependent Claim
46 words
001 to 1.0 percent by weight of a second compound selected from compounds of the formula: ##STR8## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X - is an anion; and a pharmacologically acceptable carrier.
Claim 22
Dependent Claim
14 words
A composition according to claim 16 in which the carrier is an aqueous carrier.
Claim 23
Dependent Claim
19 words
A composition according to claim 16 in which the first compound is acetylcholine and the second compound is carbachol.
References Cited (Backward Citations)
US3870791A
Cited
US4405627A
Cited
US4459309A
Cited
US4490379A
Cited
US4665094A
Cited
US4853224A
Cited
US5009892A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-19 | 1997-01-18 | 1997-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-19 | 2001-01-18 | 2001-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-19 | 2005-01-18 | 2005-07-20 | $7700.00 | Window Closed / Lapsed |