US4405627A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diphenylpropylamino-pyridine compounds useful as medicines
Assignee: Rbs Pharma (Roger Bellon Schoum) SpA
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Filing: 1981-05-07
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Granted: 1983-09-20
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Expires: 2001-05-07
Abstract
Abstract Novel diphenylpropylamino-pyridine derivatives of general formula: ##STR1## are described and the spasmolytic, miorelaxing and local in vitro and in vivo anesthetic properties of some of them are given on the basis of experimental data as resulting from tests carried out on animals and isolated organs. The synthetized and tested compounds, which are endowed with a low toxicity, reduce the spontaneous motility and the drug-induced contractions, without anticholinergic side-effects at a central level.
Inventors
- 👤 Paolo Masi
- 👤 Angela Monopoli
- 👤 Adone C. Saravalle
- 👤 Cesare Zio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 01:00
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/75
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
119 words
A method of treating spastic syndromes in the muscular tissues of mammals comprising administering to the mammal a unitary dosage of from about 20 to 100 mg per kilogram of body weight of a compound having the formula: ##STR4## wherein the diphenylpropylamino group is bound at position 2 or 3 of the pyridine ring; R is selected from the group consisting of hydrogen, a lower linear or branched alkyl group having from 1 to 4 carbon atoms and arakyl; X is selected from chlorine, bromine and iodine, Y is selected from hydrogen, fluorine, bromine, chlorine and methoxy; Z is Oxygen or H 2 and n is zero or 1, provided that Z is H 2 when n is one.
Claim 2
Independent Claim
119 words
A method of treating spastic syndromes in the muscular tissues of mammals comprising administering to the mammal a unitary dosage of from about 20 to 100 mg per kilogram of body weight of a compound having the formula: ##STR4## wherein the diphenylpropylamino group is bound at position 2 or 3 of the pyridine ring; R is selected from the group consisting of hydrogen, a lower linear or branched alkyl group having from 1 to 4 carbon atoms and arakyl; X is selected from chlorine, bromine and iodine, Y is selected from hydrogen, fluorine, bromine, chlorine and methoxy; Z is Oxygen or H 2 and n is zero or 1, provided that Z is H 2 when n is one.
Claim 3
Dependent Claim
25 words
A method according to claim 1, wherein the said compound has the following formula: ##STR5## and wherein R, X and n are as therein defined.
Claim 4
Dependent Claim
11 words
A method according to claim 1, wherein said compounds is N-(2'-pyridyl)-3,3-diphenylpropylamine.
Claim 5
Dependent Claim
11 words
A method according to claim 1, wherein said compound is N-(3'-pyridyl)-3,3-diphenylpropylamine.
Claim 6
Dependent Claim
12 words
A method according to claim 1, wherein said compound is 2-(3',3'-diphenylpropyl-1'-amino)-1-methylpyridinium iodide.
References Cited (Backward Citations)
US4180670A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |