US5009892A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rapid miosis with control of intraocular pressure
Assignee: Individual
•
Filing: 1989-03-03
•
Granted: 1991-04-23
•
Expires: 2009-03-03
Abstract
Abstract Quick miosis with 24 hour control of intraocular pressure of patients undergoing extracapsular cataract extraction surgery is achieved by applying to the eyes of the patient during surgery acetylcholine as a first miotic agent and carbachol as a second miotic agent. Acetylcholine provides quick miosis while carbachol enhances the miotic effect while providing post-surgery control of intraocular pressure. The two miotic agents can be dissolved in a common saline carrier. The two agents can be combined in a unit dosage package by disposing acetylcholine in powder form in a first compartment and a solution of carbachol in a second compartment. The combined miotic agent of the invention is especially useful when substances which raise IOP such as viscoelastic agents are used during ocular surgery and/or with sensitive patients who enter the surgery with elevated pressure such as those suffering from glaucoma.
Inventors
- 👤 James W. McKinzie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:54
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
144 words
A method of inducing quick miosis while controlling intraocular pressure in a mammal during ocular surgery comprising the steps of: applying to the eye of the mammal during ocular surgery an aqueous solution containing from 0.1 to 5% by weight of a first miotic agent dissolved in a pharmacologically acceptable aqueous carrier, said first agent being selected from compounds of the formula: ##STR3## where R and R 1 are lower alkyl groups containing 1 to 5 carbon atoms and X - is an anion; and applying to the eye during said surgery an aqueous saline solution containing 0.001 to 1.0 percent by weight of a second miotic agent dissolved in pharmacologically acceptable aqueous carrier selected from compounds of the formula: ##STR4## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X is an anion.
Claim 2
Independent Claim
144 words
A method of inducing quick miosis while controlling intraocular pressure in a mammal during ocular surgery comprising the steps of: applying to the eye of the mammal during ocular surgery an aqueous solution containing from 0.1 to 5% by weight of a first miotic agent dissolved in a pharmacologically acceptable aqueous carrier, said first agent being selected from compounds of the formula: ##STR3## where R and R 1 are lower alkyl groups containing 1 to 5 carbon atoms and X - is an anion; and applying to the eye during said surgery an aqueous saline solution containing 0.001 to 1.0 percent by weight of a second miotic agent dissolved in pharmacologically acceptable aqueous carrier selected from compounds of the formula: ##STR4## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X is an anion.
Claim 3
Dependent Claim
19 words
A method according to claim 1 in which R and R 1 are methyl and X - is chloro.
Claim 4
Dependent Claim
19 words
A method according to claim 2 in which R 2 is methyl, n is O and X is chloro.
Claim 5
Dependent Claim
17 words
A method according to claim 3 in which the two agents are applied to the eye sequentially.
Claim 6
Dependent Claim
20 words
A method according to claim 4 in which the first agent is applied to the eye before the second agent.
Claim 7
Dependent Claim
17 words
A method according to claim 3 in which the two agents are applied to the eye simultaneously.
Claim 8
Dependent Claim
14 words
A method according to claim 1 in which X - is a halogen anion.
Claim 9
Dependent Claim
28 words
A method according to claim 1 in which the solution of first agent further includes a lyophilizing material in a weight ratio to agent of 1/1 to 10/1.
Claim 10
Dependent Claim
22 words
A method according to claim 8 in which the lyophilizing material is mannitol present in an amount of about 3% by weight.
Claim 11
Dependent Claim
13 words
A method according to claim 8 in which the lyophilizing agent is mannitol.
Claim 12
Dependent Claim
25 words
A method according to claim 1 in which the second agent is present in the saline solution in an amount of about 0.01% by weight.
Claim 13
Dependent Claim
23 words
A method according to claim 11 in which both miotic agents are dissolved in the pharmacologically acceptable aqueous saline as a common carrier.
Claim 14
Dependent Claim
93 words
A method according to claim 12 in which before applying the agents, the first agent is a dry powder and the lyophilizing agent is a dry powder in unit dosage form are disposed in a first sterile, closed package and a unit dosage of the second agent dissolved in said saline is disposed in a second sterile package and further including the steps of: combining the contents of the two packages to form a solution of the two agents in said saline and then applying said solution to the eye of said mammal.
Claim 15
Dependent Claim
13 words
A method according to claim 1 in which the mammal is a human.
Claim 16
Dependent Claim
22 words
A method according to claim 14 in which the human subject is undergoing extracapsular cataract extraction with the intraocular lens implant surgery.
Claim 17
Dependent Claim
15 words
A method according to claim 15 in which the human subject is suffering from glaucoma.
Claim 18
Dependent Claim
135 words
A unit dosage package of a combination miotic capable of quick miosis while controlling intraocular pressure comprising: a first sterile container containing a unit dosage of an aqueous saline solution comprising 0.001 to 1.0 percent by weight of a first miotic agent of the formula ##STR5## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X is an anion; a second sterile container containing a unit dosage in dry powder form of a second miotic agent selected from compounds of the formula: ##STR6## where R and R 1 are lower alkyl groups of 1-5 carbon atoms and X - is an anion; said second agent forming a solution having a concentration of 0.1 to 5 percent by weight when dissolved in said aqueous saline solution.
Claim 19
Dependent Claim
135 words
A unit dosage package of a combination miotic capable of quick miosis while controlling intraocular pressure comprising: a first sterile container containing a unit dosage of an aqueous saline solution comprising 0.001 to 1.0 percent by weight of a first miotic agent of the formula ##STR5## where R 2 is a lower alkyl group of 1-5 carbon atoms, n is an integer from 0-3 and X is an anion; a second sterile container containing a unit dosage in dry powder form of a second miotic agent selected from compounds of the formula: ##STR6## where R and R 1 are lower alkyl groups of 1-5 carbon atoms and X - is an anion; said second agent forming a solution having a concentration of 0.1 to 5 percent by weight when dissolved in said aqueous saline solution.
Claim 20
Dependent Claim
21 words
A package according to claim 17 in which the containers are joined by an elastomer seal penetrable by a hypodermic needle.
Claim 21
Dependent Claim
19 words
A package according to claim 17 in which R and R 1 are methyl and X - is chloro.
Claim 22
Dependent Claim
20 words
A package according to claim 17 in which R 2 is methyl, n is O and X - is chloro.
Claim 23
Dependent Claim
13 words
A package according to claim 17 in which the containers are physically joined.
Claim 24
Dependent Claim
17 words
A method according to claim 1 in which the agents are applied to the eye by injection.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-04-22 | 1994-10-22 | 1995-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-22 | 1998-10-22 | 1999-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-22 | 2002-10-22 | 2003-04-23 | $7700.00 | Window Closed / Lapsed |