US4459309A
Expired / Lapsed
US
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Compositions and methods of lowering intraocular pressure in the hypertensive mammalian eye
Assignee: Texas A&M University System
•
Filing: 1980-05-05
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Granted: 1984-07-10
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Expires: 2000-05-05
Abstract
Abstract Compositions for treating open-angle glaucoma comprising N,N-dimethylaminoethyl carbamate and method of treating ocular hypertension by topically administering such compound to the hypertensive eye.
Inventors
- 👤 George C. Y. Chiou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 13:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/27
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
44 words
A method of reducing intraocular pressure in mammals having intraocular hypertension comprising topically administering to a hypertensive eye in an ophthalmologically acceptable, effective amount for lowering intraocular pressure of a compound selected from N,N-dimethylaminoethyl carbamate (N-demethylated carbachol) and ophthalmologically acceptable acid addition salts thereof.
Claim 2
Independent Claim
44 words
A method of reducing intraocular pressure in mammals having intraocular hypertension comprising topically administering to a hypertensive eye in an ophthalmologically acceptable, effective amount for lowering intraocular pressure of a compound selected from N,N-dimethylaminoethyl carbamate (N-demethylated carbachol) and ophthalmologically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
37 words
A method according to claim 1 wherein the compound is in the form of a water-soluble ophthalmologically acceptable salt and is applied topically in an aqueous solution containing between about 3% to about 9% of said salt.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein the compound is N,N-dimethylaminoethyl carbamate.
Claim 5
Independent Claim
15 words
A method according to claims 1 or 2 wherein the compound is N,N-dimethylaminoethyl carbamate hydrochloride.
Claim 6
Dependent Claim
20 words
A method according to claim 1 wherein the compound is topically applied in the form of an ointment or lamella.
Claim 7
Dependent Claim
52 words
The method according to claim 1 wherein said compound is topically applied by an ophthalmologically acceptable polymeric ocular insert placed and retained in contact with the eyeball, said compound being diffusible from said insert at a rate sufficient to provide an ophthalmologically acceptable, effective intraocular pressure lowering dose thereof to the eye.
Claim 8
Dependent Claim
35 words
An ophthalmic composition for the topical treatment of open-angle glaucoma comprising in solution an intraocular pressure lowering effective amount of a water-soluble ophthalmologically aceptable acid addition salt of N,N-dimethylaminoethyl carbamate and a liquid ophthalmic carrier.
Claim 9
Dependent Claim
35 words
An ophthalmic composition for the topical treatment of open-angle glaucoma comprising in solution an intraocular pressure lowering effective amount of a water-soluble ophthalmologically aceptable acid addition salt of N,N-dimethylaminoethyl carbamate and a liquid ophthalmic carrier.
Claim 10
Dependent Claim
16 words
An ophthalmic composition according to claim 7 wherein said acid addition salt is N,N-dimethylaminoethyl carbamate hydrochloride.
Claim 11
Dependent Claim
22 words
An ophthalmic composition according to claim 8 wherein the solution comprises from about 3% to about 9% by weight N,N-dimethylaminoethyl carbamate hydrochloride.
Claim 12
Dependent Claim
29 words
A pharmaceutical unit dosage form for the topical treatment of open-angle glaucoma comprising about 4.5 mgs. to about 9.0 mgs. of N,N-dimethylaminoethyl carbamate hydrochloride in an isotonic aqueous solution.
Claim 13
Dependent Claim
29 words
A pharmaceutical unit dosage form for the topical treatment of open-angle glaucoma comprising about 4.5 mgs. to about 9.0 mgs. of N,N-dimethylaminoethyl carbamate hydrochloride in an isotonic aqueous solution.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-10 | 1988-01-09 | 1988-07-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-10 | 1992-01-09 | 1992-07-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-10 | 1996-01-09 | 1996-07-10 | $7700.00 | Window Closed / Lapsed |