US5225183A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicinal aerosol formulations
Assignee: 3M Innovative Properties Co
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Filing: 1991-01-30
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Granted: 1993-07-06
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Expires: 2011-01-30
Abstract
Abstract A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
Inventors
- 👤 Tarlochan S. Purewal
- 👤 David J. Greenleaf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/008; A61K9/10; A61K9/12; A61K9/124
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
103 words
An aerosol formulation comprising: (a) a therapeutically effective amount of a medicament; (b) a propellant substantially free of chlorofluorocarbons, said propellant comprising 1,1,1,2-tetrafluoroethane; (c) a surface active agent in an amount sufficient (i) to stabilize the formulation or (ii) lubricate a valve stem in a metering valve; and (d) at least one compound selected from the group consisting of ethyl alcohol, isopropyl alcohol, n-pentane, isopentane, neopentane, isopropyl, and myristate, said compound being present in an amount such that it is miscible with the 1,1,1,2-tetrafluoroethane and such that said surface active agent is soluble in the formulation in a greater amount than in 1,1,1,2-tetrafluoroethane.
Claim 2
Dependent Claim
103 words
An aerosol formulation comprising: (a) a therapeutically effective amount of a medicament; (b) a propellant substantially free of chlorofluorocarbons, said propellant comprising 1,1,1,2-tetrafluoroethane; (c) a surface active agent in an amount sufficient (i) to stabilize the formulation or (ii) lubricate a valve stem in a metering valve; and (d) at least one compound selected from the group consisting of ethyl alcohol, isopropyl alcohol, n-pentane, isopentane, neopentane, isopropyl, and myristate, said compound being present in an amount such that it is miscible with the 1,1,1,2-tetrafluoroethane and such that said surface active agent is soluble in the formulation in a greater amount than in 1,1,1,2-tetrafluoroethane.
Claim 3
Dependent Claim
22 words
The formulation of claim 1 wherein the weight ratio of 1,1,1,2-tetrafluoroethane to compound (d) is in the range of 50:50 to 99:1.
Claim 4
Dependent Claim
29 words
The formulation of claim 1 wherein said medicament is a member selected from the group consisting of salbutamol, beclomethasone dipropionate, disodium cromoglycate, pirbuterol, isoprenaline, adrenaline, rimiterol, and ipratropium bromide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-05 | 1997-01-04 | 1997-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-05 | 2001-01-04 | 2001-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-05 | 2005-01-04 | 2005-07-06 | $7700.00 | Window Closed / Lapsed |