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US4405598A Expired / Lapsed US ⏱️ 0.0 years remaining

Composition for treating asthma

Assignee: Fisons Ltd
•
Filing: 1981-01-13
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Granted: 1983-09-20
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Expires: 2001-01-13
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Abstract

Abstract There is described a method of treatment of asthma which comprises administration to an asthmatic patient of an effective amount of an inhalation composition consisting essentially of a dispersion or suspension of from 0.2 to 2.0% disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture comprising dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane, in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapor pressure in the range 35 to 70 pounds per square inch gauge. There is also described disodium cromoglycate having a mass median diameter of less than 20 microns, more preferably in the range 0.01 to 10 microns, and most preferably at least 50% by weight of the particles having a diameter of 2 to 5 microns and containing less than 1% by weight of water.

Inventors

  • 👤 Kenneth Brown

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 06:09
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/008; A61K31/00; A61K31/33; A61K31/335; A61K31/35; C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 129 words
A method of treatment of asthma which comprises administration to an asthmatic patient of an effective amount of an inhalation composition comprising a dispersion or suspension of from 0.2 to 2.0% of disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture comprising dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane and containing substantially no trichloromonofluoromethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapour pressure in the range 35 to 70 pounds per square inch gauge.
Claim 2
Independent Claim 129 words
A method of treatment of asthma which comprises administration to an asthmatic patient of an effective amount of an inhalation composition comprising a dispersion or suspension of from 0.2 to 2.0% of disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture comprising dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane and containing substantially no trichloromonofluoromethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapour pressure in the range 35 to 70 pounds per square inch gauge.
Claim 3
Dependent Claim 36 words
A method according to claim 1, wherein at least 50% by weight of the particles of disodium cromoglycate have a diameter of 2 to 5 microns and containing from 0.2 to 1.2% by weight of surfactant.
Claim 4
Dependent Claim 107 words
An inhalation composition comprising a dispersion or suspension of from 0.2 to 2.0% disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture consisting essentially of dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapour pressure in the range 35 to 70 pounds per square inch gauge.
Claim 5
Dependent Claim 107 words
An inhalation composition comprising a dispersion or suspension of from 0.2 to 2.0% disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture consisting essentially of dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapour pressure in the range 35 to 70 pounds per square inch gauge.

References Cited (Backward Citations)

US3560607A Cited
US3282791A Cited
US3897779A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1986-09-19 1987-03-21 1987-09-20 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1990-09-19 1991-03-21 1991-09-20 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1994-09-19 1995-03-21 1995-09-20 $7700.00 Window Closed / Lapsed

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