US4590206A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhalation pharmaceuticals
Assignee: King Pharmaceuticals Inc
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Filing: 1984-05-03
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Granted: 1986-05-20
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Expires: 2004-05-03
Abstract
Abstract There is described a finely divided inhalation drug, e.g. sodium cromoglycate, comprising a therapeutically effective proportion of individual particles capable of penetrating deep into the lung, characterized in that a bulk of the particles which is both unagglomerated and unmixed with a coarse carrier, is sufficiently free flowing to be filled into capsules on an automatic filling machine and to empty from an opened capsule in an inhalation device. A number of the individual drug particles have a spherical, collapsed spherical or ring doughnut shape. There is also described a method of making the fine particles and pharmaceutical formulations containing them.
Inventors
- 👤 Raymond B. Forrester
- 👤 Terence D. Boardman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 15:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/0075; A61K9/14; A61K9/16; A61K9/1682; A61K9/1688; A61P; A61P11/00; A61P37/00; A61P37/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
59 words
A capsule, cartridge, or aerosol container containing an inhalation drug for the treatment of allergic airway disease, said drug consisting essentially of spray-dried sodium cromoglycate in finely divided and unagglomerated form, wherein a substantial proportion of the individual drug particles have a ring doughnut shape, at least 50% by weight of said particles having diameters less than 60 microns.
Claim 2
Dependent Claim
59 words
A capsule, cartridge, or aerosol container containing an inhalation drug for the treatment of allergic airway disease, said drug consisting essentially of spray-dried sodium cromoglycate in finely divided and unagglomerated form, wherein a substantial proportion of the individual drug particles have a ring doughnut shape, at least 50% by weight of said particles having diameters less than 60 microns.
Claim 3
Dependent Claim
25 words
A capsule, cartridge or container in accordance with claim 1, wherein said inhalation drug has a permeametry:BET ratio in the range of 0.5 to 1.0.
Claim 4
Dependent Claim
24 words
A capsule, cartidge or container in accordance with claim 1 wherein the particle density of said drug is 1.3 to 1.7 g/cm 3 .
Claim 5
Dependent Claim
25 words
A capsule, cartridge or container in accordance with claim 1 wherein said drug has a loose bulk density of greater than 0.3 g/cm 3 .
Claim 6
Dependent Claim
25 words
A capsule, cartridge or container in accordance with claim 1 wherein said drug has a packed bulk density of 0.4 to 0.75 g/cm 3 .
Claim 7
Dependent Claim
39 words
A capsule, cartridge or container in accordance with claim 1 wherein more than 90% of said drug particles are less than 60 microns in diameter and said drug has a loose bulk density greater than 0.3 g/cm 3 .
Claim 8
Dependent Claim
39 words
A capsule, cartridge or container in accordance with claim 1 wherein more than 90% of said drug particles are less than 60 microns in diameter and said drug has a packed density of 0.4 to 0.75 g/cm 3 .
Claim 9
Dependent Claim
25 words
A capsule, cartridge or container in accordance with claim 1 wherein at least 50% of said drug particles are less than 10 microns in diameter.
Claim 10
Dependent Claim
100 words
A capsule containing a finely divided inhalation formulation comprising a therapeutically effective proportion of individual particles consisting essentially of sodium cromoglycate, in unagglomerated form and capable of penetrating deep into the lung, at least 50% by weight of said particles having diameters less than 60 microns, said particles being sufficiently free-flowing to be filled into said capsule on an automatic filling machine and to empty from an opened capsule in an inhalation device, a substantial proportion of the individual drug particles having a ring doughnut shape, the permeametry:BET ratio of the particles being in the range of 0.5 to 1.0.
Claim 11
Dependent Claim
100 words
A capsule containing a finely divided inhalation formulation comprising a therapeutically effective proportion of individual particles consisting essentially of sodium cromoglycate, in unagglomerated form and capable of penetrating deep into the lung, at least 50% by weight of said particles having diameters less than 60 microns, said particles being sufficiently free-flowing to be filled into said capsule on an automatic filling machine and to empty from an opened capsule in an inhalation device, a substantial proportion of the individual drug particles having a ring doughnut shape, the permeametry:BET ratio of the particles being in the range of 0.5 to 1.0.
Claim 12
Dependent Claim
34 words
A method of administering sodium cromoglycate to a patient by way of inhalation comprising rotating and vibrating an opened capsule according to claim 1, in an air stream which is inhaled by the patent.
References Cited (Backward Citations)
US3957965A
Cited
US4161516A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-19 | 1989-11-18 | 1990-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-19 | 1993-11-18 | 1994-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-19 | 1997-11-18 | 1998-05-20 | $7700.00 | Window Closed / Lapsed |