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US5203991A
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Packing material for liquid chromatography
Assignee: Shiseido Co Ltd
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Filing: 1991-10-17
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Granted: 1993-04-20
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Expires: 2011-10-17
Abstract
Abstract A packing material for liquid chromatography bears a polyalkylene polyamine moiety linked through a spacer moiety as the pendant group to a porous silica gel coated with a silicone polymer, and optionally is crosslinked by a crosslinking agent on two or more amino group of the different polyalkylene polyamine moieties, and a process for production thereof. Such a packing material is especially useful in the analysis of sugars.
Inventors
- 👤 Hiroshi Kutsuna
- 👤 Yoshihiro Shiojima
- 👤 Tsuneo Suhara
- 👤 Hiroshi Fukui
- 👤 Yutaka Ohtsu
- 👤 Michihiro Yamaguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:33
CPC Classifications
B; B01; B01D; B01D15/00; B01D15/08; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/262; B01J20/265; B01J20/267; B01J20/28; B01J20/28054; B01J20/28078; B01J20/281; B01J20/286; B01J20/289; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3268; B01J20/3272; B01J20/328; B01J20/3282; B01J20/3289; B01J2220/00; B01J2220/50; B01J2220/54; B01J2220/58
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
146 words
A packing material for liquid chromatography comprising a moiety derived from a porous silica gel coated with a silicone polymer containing a SiH group, a spacer moiety having two ends and a polyalkylene polyamine portion having an amino group capable of bonding to the spacer moiety, said packing material wherein: A. the silicon atom derived from a SiH group of the aforesaid silica gel moiety is silicon-carbon covalently bonded to one end of the spacer moiety, and the other end of the spacer moiety is carbon-nitrogen or sulfur-nitrogen covalently bonded to the amino group of the polyalkylene polyamine; and B. the spacer constituting portion between said both bonds is a group having 3 to 15 constituent atoms of a main chain, and comprises a substituted or unsubstituted hydrocarbon chain which is or is not interrupted with at least one oxygen atom, sulfur atom or nitrogen atom.
Claim 2
Dependent Claim
146 words
A packing material for liquid chromatography comprising a moiety derived from a porous silica gel coated with a silicone polymer containing a SiH group, a spacer moiety having two ends and a polyalkylene polyamine portion having an amino group capable of bonding to the spacer moiety, said packing material wherein: A. the silicon atom derived from a SiH group of the aforesaid silica gel moiety is silicon-carbon covalently bonded to one end of the spacer moiety, and the other end of the spacer moiety is carbon-nitrogen or sulfur-nitrogen covalently bonded to the amino group of the polyalkylene polyamine; and B. the spacer constituting portion between said both bonds is a group having 3 to 15 constituent atoms of a main chain, and comprises a substituted or unsubstituted hydrocarbon chain which is or is not interrupted with at least one oxygen atom, sulfur atom or nitrogen atom.
Claim 3
Dependent Claim
45 words
A packing material according to claim 1, wherein the spacer constituting portion is a moiety selected from the group consisting of substituted or unsubstituted alkylene, alkenylene, arylene, alkylene-arylene and dialkylenearyl which are or are not interrupted with at least one oxygen, sulfur or nitrogen atom.
Claim 4
Dependent Claim
36 words
A packing material according to claim 1, wherein the spacer moiety is derived from a compound selected from the group consisting of allylglycidyl ether, epoxy alkenes, halomethyl styrenes, allylhalide, allylisocyanate, allylisothiocyanate, allylacetic acid and allylsulfonic acid.
Claim 5
Dependent Claim
45 words
A packing material according to claim 1, wherein the polyalkylene polyamine is at least one compound selected from the group consisting of compounds having the formula: ##STR2## wherein n is an integer of 2 to 4, and m is an integer of 1 to 10.
Claim 6
Dependent Claim
66 words
A packing material according to claim 1, wherein the spacer moiety is derived from a compound selected from the group consisting of allylglycidyl ether, 1,2-epoxy-5-hexane and chloromethyl styrene, and the polyalkylene polyamine is at least one compound selected from the group consisting of compounds having the formula: ##STR3## wherein n is an integer of 2 to 4, and m is an integer of 1 to 10.
Claim 7
Dependent Claim
45 words
A packing material for liquid chromatography comprising a packing material which is the packing material of claim 1 crosslinked by a crosslinking agent through two or more amino groups of different polyalkylene polyamine moieties bonded to the same silica gel coated with a silicone polymer.
Claim 8
Dependent Claim
42 words
A packing material according to claim 6, wherein a crosslinking agent is a compound selected from the group consisting of formaldehyde, acetoaldehyde, glutaraldehyde, glycerol, diglycidyl ether, ethyleneglycol diglycidyl ether, glycerol triglycidyl ether, oxalic acid, succinic acid, adipic acid, epichlorohydrin and tetramethylene diisocyanate.
Claim 9
Dependent Claim
78 words
A packing material according to claim 7, wherein the packing material to be crosslinked is a packing material of wherein the spacer moiety is derived from a compound selected from the group consisting of allylglycidyl ether, 1,2-epoxy-5-hexane and chloromethyl styrene, and the polyalkylene polyamine is at least one compound selected from the group consisting of compounds having the formula: ##STR4## wherein n is an integer of 2 to 4, and m is an integer of 1 to 10.
Claim 10
Dependent Claim
13 words
A packing material according to claim 8, wherein the crosslinking agent is formaldehyde.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-04-19 | 1996-10-19 | 1997-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-04-19 | 2000-10-19 | 2001-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-19 | 2004-10-19 | 2005-04-20 | $7700.00 | Window Closed / Lapsed |