Patent US5196510A successfully refreshed from Google Patents.
US5196510A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Molecular recognition units
Assignee: Cytogen Corp
•
Filing: 1990-05-07
•
Granted: 1993-03-23
•
Expires: 2010-05-07
Abstract
Abstract A system or method for identifying and/or designing novel peptides and polypeptides comprising an amino acid sequence which mimics the molecular recognition site of either (a) a macromolecule such as an immunoglobulin, an enzyme, a receptor protein, a lectin or other binding protein or (b) a small molecule or a small region of a large molecule which functions as a ligand and is recognized and binds specifically to a macromolecule is disclosed. Novel peptides and polypeptides as well as conjugates of the peptides and polypeptides are also disclosed. Applications for use of the peptides, polypeptides and conjugates in a wide range of fields such as biomedicine; biological control and pest regulation; agriculture; cosmetics; environmental control and waste management; chemistry; catalysis; nutrition and food industries; military uses; climate control, etc. are disclosed.
Inventors
- 👤 John D. Rodwell
- 👤 Thomas J. McKearn
- 👤 Vernon L. Alvarez
- 👤 Robert D. Radcliffe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:24
CPC Classifications
C; C07; C07K; C07K1/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/082; A61K51/088; C07K14/00; C07K14/825; C07K16/00; C07K16/18; C07K16/28; C07K16/46; C07K16/461; C07K19/00; C12; C12Q; C12Q1/00; C12Q1/02; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5008; G01N33/5044; G01N33/5047; G01N33/5052; G01N33/68; G01N33/6854; A61K2123/00; C07K2319/00; C07K2319/33
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
75 words
A compound, comprising a first amino acid sequence having binding activity and affinity for an activated platelet fibrinogen receptor and selected from the group consisting of: SYGRGDVRGDF, SGAYSRGDG, SGAYGSRGDG, SYRGDSK, PSYYRGDGAPSYYRGDGA, PSYYRGDGAPSYYRGDGAPSYYRGDA, ARRSPSYYRGDAGPYYAMDY, attached directly to a second amino acid sequence capable of binding a metal ion selected from the group consisting of: KCTCCA, SCTCTSSCA, ACKACKC, GCSKCAQGCV, CKGAADKCTCCA, GHFPFHW, YKCGLCERSFVEKSALSRHQRVKKN, and such peptides in which either or both the amino or carboxy terminus is blocked.
Claim 2
Dependent Claim
75 words
A compound, comprising a first amino acid sequence having binding activity and affinity for an activated platelet fibrinogen receptor and selected from the group consisting of: SYGRGDVRGDF, SGAYSRGDG, SGAYGSRGDG, SYRGDSK, PSYYRGDGAPSYYRGDGA, PSYYRGDGAPSYYRGDGAPSYYRGDA, ARRSPSYYRGDAGPYYAMDY, attached directly to a second amino acid sequence capable of binding a metal ion selected from the group consisting of: KCTCCA, SCTCTSSCA, ACKACKC, GCSKCAQGCV, CKGAADKCTCCA, GHFPFHW, YKCGLCERSFVEKSALSRHQRVKKN, and such peptides in which either or both the amino or carboxy terminus is blocked.
Claim 3
Dependent Claim
12 words
The compound of claim 1, in which the carboxy terminus is blocked.
Claim 4
Dependent Claim
12 words
The compound of claim 1, in which the amino terminus is blocked.
Claim 5
Dependent Claim
17 words
The compound according to claim 1, in which the amino terminus and the carboxy terminus are blocked.
Claim 6
Dependent Claim
31 words
The compound according to claim 1, in which the first amino acid sequence is SYGRGDVRGDF or the peptide thereof in which either or both the amino and carboxy terminus is blocked.
Claim 7
Dependent Claim
33 words
The compound according to claim 1, in which the second sequence is a peptide of the sequence: KCTCCA or the peptide in which either or both the amino or carboxy terminus is blocked.
Claim 8
Dependent Claim
18 words
The compound according to claim 1, further comprising a metal ion bound to the second amino acid sequence.
Claim 9
Dependent Claim
34 words
The compound according to claim 7, in which the metal ion is a radioactive metal ion, a positron-emitting metal ion, a fluorescent metal ion, a chemiluminescent metal ion or a non-radioactive paramagnetic metal ion.
Claim 10
Dependent Claim
34 words
The compound according to claim 8, in which the radioactive metal ion is selected from the group consisting of radioactive iostopes of zinc, cadmium, lead, copper, silver, mercury, bismuth, cobalt, nickel, technetium and rhenium.
Claim 11
Dependent Claim
35 words
The compound according to claim 1, in which the first amino acid sequence is SYGRGDVRGDF and the second amino acid is sequence KCTCCA or the peptide in which the amino or carboxy terminus is blocked.
Claim 12
Dependent Claim
19 words
The compound according to claim 10, in which the carboxy terminus is amidated and the amino terminus is acetylated.
Claim 13
Dependent Claim
18 words
The compound according to claim 10, further comprising a metal ion bound to the second amino acid sequence.
Claim 14
Dependent Claim
27 words
A peptide selected from the group consisting of: SYGRGDVRGDFKCTCCA, KCTCCAPSYYRGDGAPSYYRGDGAPSYYRGDA, and PSYYRGDGAPSYYRGDAPSYYRGDAKCTCCA and such peptides in which either or both the amino or carboxy terminus is blocked.
Claim 15
Dependent Claim
27 words
A peptide selected from the group consisting of: SYGRGDVRGDFKCTCCA, KCTCCAPSYYRGDGAPSYYRGDGAPSYYRGDA, and PSYYRGDGAPSYYRGDAPSYYRGDAKCTCCA and such peptides in which either or both the amino or carboxy terminus is blocked.
Claim 16
Dependent Claim
16 words
The peptide according to claim 13, further comprising a metal ion bound to the KCTCCA group.
Claim 17
Dependent Claim
34 words
The compound according to claim 13, in which the metal ion is a radioactive metal ion, a positron-emitting metal ion, a fluorescent metal ion, a chemiluminescent metal ion or a non-radioactive paramagnetic metal ion.
Claim 18
Dependent Claim
34 words
The compound according to claim 15, in which the radioactive metal ion is selected from the group consisting of radioactive isotopes of zinc, cadmium, lead, copper, silver, mercury, bisimuth, cobalt, nickel, technetium and rhenium.
References Cited (Backward Citations)
US4517686A
Cited
US4578079A
Cited
US4589881A
Cited
US4614517A
Cited
US4792525A
Cited
US4741900A
Cited
US4629783A
Cited
US4879237A
Cited
US4683291A
Cited
US4683291B1
Cited
WO1988009344A1
Cited
WO1989005150A1
Cited
EP0368684B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-22 | 1996-09-21 | 1997-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-22 | 2000-09-21 | 2001-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-22 | 2004-09-21 | 2005-03-23 | $7700.00 | Window Closed / Lapsed |