Fluoromacrolides having immunosuppressive activity

Claim 2

A compound of Formula I: ##STR196## or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are independently selected from: 1) --N 3 ; 2) --NHCN; 3) --NR 6 R 7 , wherein R 6 and R 7 independently, are a) hydrogen, b) C 1-12 alkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are independently selected from the group consisting of: i) hydrogen, ii) --OH, iii) C 1-6 alkoxy, iv) --O--CO--C 1-6 alkyl, v) --NR 10 R 11 , wherein R 10 and R 11 are independently, hydrogen, or C 1--6 alkyl, unsubstituted or substituted with phenyl vi) --CONR 10 R 11 , vii) --CO 2 H, viii) --CO--O--C 1-6 alkyl, ix) --S--C 1-6 alkyl, x) --SO--C 1-6 alkyl, xi) --SO 2 --C 1-6 alkyl, xii) halo, xiii) --C 3-7 -cycloalkyl, xiv) phenyl, unsubstituted or substituted with X, Y and Z, xv) naphthyl, unsubstituted or substituted with X, Y and Z, xvi) --CF 3 , c) C 3-12 -alkenyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, d) C 3-7 cycloalkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, e) phenyl, unsubstituted or substituted with X, Y and Z, f) naphthyl, unsubstituted or substituted with X, Y and Z, g) --SO 2 -phenyl, wherein phenyl is unsubstituted or substituted with X, Y and Z, h) --SO 2 --C 1-6 alkyl, i) or where R 6 and R 7 and the N to which they are attached may form a heterocyclic ring selected from the group consisting of: morpholine, thiomorpholine, piperidine, and piperazine, and where the substituent(s), attached to the carbon atom(s) in the heterocyclic ring is/are independently selected from the group consisting of: i) hydrogen, ii) --OH, iii) C 1-6 alkoxy, iv) --O--CO--C 1-6 alkyl, v) --NR 10 R 11 , wherein R 10 and R 11 are as defined above, vi) --CONR 10 R 11 , vii) --CO 2 H, viii) --CO--O--C 1-6 alkyl, ix) --SH, x) halo, xi) phenyl, unsubstituted or substituted with X, Y and Z, xii) naphthyl, unsubstituted or substituted with X, Y and Z, xiii) --CF 3 ; 4) --N(R 6 )CO--O--R 12 , wherein R 6 is as defined above and R 12 is C 1-12 alkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above; 5) --N(R 6 )CO--R 13 , wherein R 6 is as defined above and R 13 is a) hydrogen, b) C 1-12 alkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, c) C 3-12 cycloalkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, d) phenyl, unsubstituted or substituted with X, Y and Z, e) naphthyl, unsubstituted or substituted with X, Y and Z, or f) where R 6 and R 13 and the --NCO-- to which they are attached may form an unsubstituted or substituted 5- to 7-membered heterocyclic ring which may include one or two additional heteroatoms independently selected from the group consisting of O, S, or NR 10 , wherein R 10 is as defined above; 6) --N(R 14 )COCH(R 22 )NR 6 R 7 wherein R 6 and R 7 are as defined above, R 14 is selected from the definitions of R 6 , and R 22 is a) hydrogen, b) C 1-4 alkyl, unsubstituted or substituted with R 23 , wherein R 23 is selected from the group consisting of: i) --OH, ii) C 1-6 alkoxy, iii) --O--CO--C 1-6 alkyl, iv) --SH, v) --S--C 1-6 alkyl, vi) --NR 10 R 11 , wherein R 10 and R 11 are as defined above, vii) --CO 2 H, viii) --CONH 2 , ix) imidazolyl, x) indolyl, xi) phenyl, and xii) p-hydroxyphenyl, or c) phenyl; 7) --N(R 14 )CO(CH 2 ) m NR 6 R 7 , wherein m is 0 or 2-6, R 6 and R 7 are as defined above, and R 14 is selected from the definitions of R 6 , or where R 14 and R 6 and the --NCO(CH 2 ) m N-- to which they are attached may form an unsubstituted or substituted 5- to 7-membered heterocyclic ring; 8) --N═C(R 14 )--NR 6 R 7 , wherein R 6 and R 7 are as defined above, and R 14 is selected from the definitions of R 6 , and wherein if either R 6 or R 7 are hydrogen, the tautomeric structure --NHC(R 14 )═NR 6 or 7 is also possible; 9) --N(R 15 ) 3 +A - , wherein R 15 is C 1-6 alkyl, unsubstituted or substituted with phenyl or naphthyl, and wherein A - is a counterion selected from the group consisting of: acetate, adipate, benzoate, benzenesulfonate, bisulfate, butyrate, citrate, camphorate, camphorsulfonate, ethanesulfonate, fumarate, hemisulfate, hemitartrate, heptaonate, hexanoate, chloride, bromide, iodide, methanesulfonate, lactate, maleate, methanesulfonate 2-naphthalenesulfonate, nitrate, oxalate, pamoate, perchlorate, persulfate, picrate, pivalate, propionate, succinate, tartrate, tosylate, and undecanoate; and 10) ##STR197## wherein R 16 and R 17 are independently, a) hydrogen, b) phenyl, unsubstituted or substituted with X, Y and Z, c) naphthyl, unsubstituted or substituted with X, Y and Z, d) --CN, e) --CF 3 , f) --CO--C 1-6 alkyl, or g) --CO--O--C 1-6 alkyl; 11) C 1-10 alkoxy; 12) substituted C 1-10 alkoxy in which one or more substituent(s) is(are) selected from: a) hydroxy, b) C 1-6 alkoxy, c) phenyl C 1-3 alkoxy, d) substituted phenyl C 1-3 alkoxy, in which the substituents on phenyl are X, Y and Z, e) --OCOC 1-6 alkyl, f) --NR 10 R 11 , wherein R 10 and R 11 are as defined above, g) --NR 6 COC 1-6 alkyl, wherein R 6 is as defined above, h) --COOR 6 , wherein R 6 is as defined above, i) --CHO, j) phenyl, k) substituted phenyl in which the substituents are X, Y and Z, l) phenyloxy, m) substituted phenyloxy in which the substituents are X, Y and Z, n) 1- or 2-naphthyl, o) substituted 1- or 2-naphthyl in which the substituents are X, Y and Z, p) biphenyl, and q) substituted biphenyl in which the substituents are X, Y and Z; 13) C 3-10 alkenyloxy; 14) substituted C 3-10 alkenyloxy in which one or more substituent(s) is(are) selected from: a) hydroxy, b) C 1-6 alkoxy, c) --OCO--C 1-6 alkyl, d) C 2-8 alkenyl, e) phenyl, f) substituted phenyl in which the substituents are X, Y and Z, g) 1- or 2-naphthyl, h) substituted 1- or 2-naphthyl in which the substituents are X, Y and Z, i) biphenyl, and j) substituted biphenyl in which the substituents are X, Y and Z; 15) C 3-10 alkynyloxy; and 16) substituted C 3-10 alkynyloxy in which one or more substituent(s) is(are) selected from: a) hydroxy, b) C 1-6 alkoxy, c) --OCO--C 1-6 alkyl, d) phenyl, e) substituted phenyl in which the substituents are X, Y and Z, f) 1- or 2-naphthyl, g) substituted 1- or 2-naphthyl in which the substituents are X, Y and Z, h) biphenyl, and i) substituted biphenyl in which the substituents are X, Y and Z; 17) phenyloxy; 18) substituted phenyloxy in which the substituents are X, Y and Z; 19) 1- or 2- naphthyloxy; 20) substituted 1- or 2-naphthyloxy in which the substituents are X, Y and Z; 21) biphenyloxy; 22) substituted biphenyloxy in which the substituents are X, Y and Z; and 23) hydroxy; or 24) where R 1 and R 2 may be both connected to form a 3- to 7-membered heterocyclic ring of the form; ##STR198## wherein p is zero or one, R 6 is as defined above, and A is a) --CO--, b) --CS--, c) --CO--C 1 -alkyl, d) --CS--C 1 -alkyl, or e) --C 1-2 --alkyl, wherein the alkyl may be unsubstituted or substituted with one or more of the following: i) --OH, ii) C 1-6 alkyl, iii) C 1-6 alkoxy, iv) --O--CO--C 1-6 alkyl, v) --NR 9 R 10 , wherein R 9 and R 10 are as defined above, vi) --CONR 9 R 10 , vii) --CO 2 H, viii) --CO--O--C 1-6 alkyl, ix) --S--C 1-6 alkyl, x) --SO--C 1-6 alkyl, xi) --SO 2 --C 1-6 alkyl, xii) halo, xiii) phenyl, unsubstituted or substituted with X, Y or Z, or xiv) naphthyl unsubstituted or substituted with X, Y or Z; R 3 is hydrogen, hydroxy, or C 1-6 alkoxy; R 4 is hydrogen, or R 3 and R 4 taken together form a double bond; R 5 is methyl, ethyl, propyl or allyl; Q is F or OH, with the proviso that if Q is OH, R 2 is other than OH or OCH 3 ; W is O or (H, OH); X, Y and Z independently are selected from: a) hydrogen, b) C 1-7 alkyl, c) C 2-6 alkenyl, d) halo, such as Cl, Br, F or I, e) --(CH 2 ) t --NR 10 R 11 , wherein R 10 and R 11 are as defined above, and t is 0 or 2, f) --CN, g) --CHO, h) --CF 3 , i) --SR 18 , wherein R 18 is hydrogen, C 1-6 alkyl, or phenyl, j) --SOR 18 , wherein R 18 is as defined above, k) --SO 2 R 18 , wherein R 18 is as defined above, l) --CONR 10 R 11 , wherein R 10 and R 11 are as defined above, m) R 19 O(CH 2 )t--wherein R 19 is hydrogen, C 1-3 alkyl, hydroxy-C 2-3 alkyl, phenyl or naphthyl and t is as defined above; n) --CH(OR 20 )(OR 21 ), wherein R 20 and R 21 are C 1-3 alkyl or taken together form an ethyl or propyl bridge, o) ##STR199## wherein R 19 and t are as defined above; and p) ##STR200## wherein R 19 and t are as defined above; or any two of X, Y and Z may be joined to form a saturated ring selected from dioxolanyl and dioxanyl; and n is 1 or 2.

Claim 3

A compound according to claim 1 wherein the steric configuration of formula I is as defined in formula III: ##STR201##

Claim 4

The compound according to claim 1 wherein: R 1 and R 2 are independently selected from: 1) --N 3 ; 2) --NR 6 R 7 , wherein R 6 and R 7 independently, are, a) hydrogen, b) C 1-12 alkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are independently selected from the group consisting of: i) hydrogen, ii) --OH, iii) --O--CO--C 1-6 alkyl, iv) --NR 10 R 11 , wherein R 10 and R 11 are independently, hydrogen, or C 1-6 alkyl, unsubstituted or substituted with phenyl v) --CONR 10 R 11 , vi) --CO 2 H, vii) --CO--O--C 1-6 alkyl, and viii) phenyl, unsubstituted or substituted with X, Y and Z, c) C 3-12 alkenyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, d) or where R 6 and R 7 and the N to which they are attached may form a heterocyclic ring selected from: morpholine, thiomorpholine, piperidine, and piperizine, and where the substituent(s), attached to the carbon atoms(s) in the heterocyclic ring is/are independently selected from the group consisting of: i) hydrogen, ii) --OH, iii) --O--CO--C 1-6 alkyl, iv) --CONR 10 R 11 , v) --CO 2 H, vi) --CO--O--C 1-6 alkyl, and vii) phenyl, unsubstituted or substituted with X, Y and Z; 3) --N(R 6 )CO--O--R 12 , wherein R 6 is as defined above and R 12 is C 1-12 alkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above; 4) --N(R 6 )CO--R 13 , wherein R 6 is as defined above and R 13 is a) hydrogen, b) C 1-12 alkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, c) C 3-12 cycloalkyl, unsubstituted or substituted with R 8 and R 9 , wherein R 8 and R 9 are as defined above, or d) phenyl, unsubstituted or substituted with X, Y and Z; 5) --N(R 14 )COCH(R 22 )NR 6 R 7 wherein R 6 and R 7 are as defined above, R 14 is selected from the definitions of R 6 , and R 22 is a) hydrogen, b) C 1-4 alkyl, unsubstituted or substituted with R 23 , wherein R 23 is selected from the group consisting of i) --OH, ii) C 1-6 alkoxy, iii) --O--CO--C 1-6 alkyl, iv) --SH, v) --S--C 1-6 alkyl, vi) --NR 10 R 11 , wherein R 10 and R 11 are as defined above, vii) --CO 2 H, viii) --CONH 2 , ix) imidazolyl, x) indolyl, xi) phenyl, and xii) p-hydroxyphenyl, or c) phenyl; 6) --N(R 14 )CO(CH 2 ) m NR 6 R 7 , wherein m is 0 or 2-6, R 6 and R 7 are as defined above, and R 14 is selected from the definitions of R 6 , or wherein R 14 and R 6 and the --NCO(CH 2 ) m N-- to which they are attached may form an unsubstituted or substituted 5- to 7-membered heterocyclic ring, such as 2-imidazolidone; 7) --N═C(R 14 )--NR 6 R 7 , wherein R 6 and R 7 are as defined above, and R 14 is selected from the definitions of R 6 , and wherein if either R 6 or R 7 are hydrogen, the tautomeric structure --NHC(R 14 )═NR 6or7 is also possible; 8) --N(R 15 ) 3 + A - , wherein R 15 is C 1-6 alkyl, unsubstituted or substituted with phenyl or naphthyl, and wherein A - is a counterion selected from the group consisting of: acetate, adipate, benzoate, benzenesulfonate, bisulfate, butyrate, citrate, camphorate, camphorsulfonate, ethanesulfonate, fumarate, hemisulfate, hemitartrate, heptanoate, hexanoate, chloride, bromide, iodide, methanesulfonate, lactate, maleate, methanesulfonate, 2-naphthalene-sulfonate, nitrate, oxalate, pamoate, perchlorate, persulfate, picrate, pivalate, propionate, succinate, tartrate, tosylate, and undecanoate; and 9) ##STR202## wherein R 16 and R 17 are independently, a) hydrogen, b) phenyl, unsubstituted or substituted with X, Y and Z, c) naphthyl, unsubstituted or substituted with X, Y and Z, d) --CN, e) --CF 3 , f) --CO--C 1-6 alkyl, or g) --CO--C 1-6 alkyl; 10) C 1-10 alkoxy; 11) substituted C 1-10 alkoxy in which one or more substituent(s) is(are) selected from: a) hydroxy, b) C 1-6 alkoxy, c) phenyl C 1-3 alkoxy, d) substituted phenyl C 1-3 alkoxy, in which the substituents on phenyl are X, Y and Z, e) --OCOC 1-6 alkyl, f) --NR 10 R 11 , wherein R 10 and R 11 are as defined above, g) --NR 6 CO--C 1-6 alkyl, wherein R 6 is as defined above, h) --COOR 6 , wherein R 6 is as defined above, i) --CHO, j) phenyl, k) substituted phenyl in which the substituents are X, Y and Z, l) phenyloxy, and m) substituted phenyloxy in which the substituents are X, Y and Z; 12) C 3-10 alkenyloxy; 13) substituted C 3-10 alkenyloxy in which one or more substituent(s) is(are) selected from: a) hydroxy, b) C 1-6 alkoxy, c) --OCO--C 1-6 alkyl, d) C 2-8 alkenyl, e) phenyl, and f) substituted phenyl in which the substituents are X, Y and Z; 14) C 3-10 alkynyloxy; 15) substituted C 3-10 alkynyloxy in which one or more substituent(s) is(are) selected from: a) hydroxy, b) C 1-6 alkoxy, c) --OCO--C 1-6 alkyl, d) phenyl, and e) substituted phenyl in which the substituents are X, Y and Z; 16) phenyloxy; 17) substituted phenyloxy in which the substituents are X, Y and Z; 18) 1- or 2-naphtyloxy; 19) substituted 1- or 2-naphthyloxy in which the substituents are X, Y and Z; and 20) hydroxy; or 21) wherein R 1 and R 2 may both connected to form a 3- to 7-membered heterocyclic ring of the form: ##STR203## wherein p is one, R 6 is as defined above, and A is a) --CO--, b) --CO--C 1 -alkyl, or c) C 1-2 -alkyl; R 3 is hydrogen or hydroxy; R 4 is hydrogen; R 5 is ethyl, propyl or allyl; Q is F or OH, with the proviso that if Q is OH, R 2 is other than OH or OCH 3 ; W is O or (H, OH); X, Y and Z independently are selected from: a) hydrogen, b) C 1-7 alkyl, c) C 2-6 alkenyl, d) halo, such as Cl, Br, F or I, e) --CHO, f) --CONR 10 R 11 , wherein R 10 and R 11 are as defined above, g) R 19 O(CH 2 ) t -- wherein R 19 is hydrogen, C 1-3 alkyl, hydroxy-C 2-3 alkyl, phenyl or naphthyl and t is 0 to 2; h) --CH(OR 20 )(OR 21 ), wherein R 20 and R 21 are C 1-3 alkyl or taken together form an ethyl or propyl bridge, i) ##STR204## wherein R 19 and t are as defined above; and j) ##STR205## wherein R 19 and t are as defined above; or any two of X, Y and Z may be joined to form a saturated ring selected from dioxolanyl or dioxanyl; and n is 1 or 2, or a pharmaceutically acceptable salt thereof.

Claim 5

A compound which is selected from the group consisting of: 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-teteeone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3",4"-dihydroxy-cyclohexyl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-dihydroxy-12-[2'-(3",4"-dihydroxy-cyclohexyl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-N-(2-propenyl)-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-N-methylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-methylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-1'"-adamantane-carboxamido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cyclopropanecarboxamid-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-formamido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-(4"-(4'",5'"-dicarboethoxy-1'",2'",3'"-triazole)-3"-methoxycyclohexyl)-1'-methylvinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-methoxy-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-hydroxy-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-amino-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-aminocyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-beta-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-alpha-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-beta-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-alpha-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-methylcarbamate-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylcarbamate-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetamidine-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzamidine-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-formamidine-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(L-phenylalanyl)-amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(L-phenylalanyl)amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2"-(4"-(D-phenylalanyl)-amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(D-phenylalanyl)amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2"-(4"-(aminoacetyl-amino)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(aminoacetylamino)-3"-methoxycyclohexyl)-4'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-hydroxypropyl-amino)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-hydroxypropylamino)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(1-aza-4-oxabicyclo-[4.4.0]dec-6-yl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(1-aza-4-oxabicyclo[4.4.0]-dec-6-yl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trimethylamino-3"methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone Iodide; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-isopropoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-isopropoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Propyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-isopropoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.31.0 4 ,9 ]octacos-18-ene-2,3,20,26-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-[4"-(N'-t-butoxycarbonyl-D-phenylalanine)amido-3"-n-propyloxycyclohexyl]-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetra-methyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-[4"-(N'-t-butoxycarbonyl-L-phenylalanine)amido-3"-n-propyloxycyclohexyl]-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetra-methyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetoxyacetylamino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(1"'-adamantanecarboxamido)-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cyclopropanecarbox-amido-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2-(4"-formamido-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-[4"',5"'-dicarboeth-oxy-1"',2"',3"'-triazole)-3"-n-propyloxycyclohexyl]-1'-methyl-vinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-ethoxycyclo-hexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-benzylamino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trimethylamino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone-Iodide; 17-Ethyl-20-fluoro-1,2,14-trihydroxy-12-[2'-(4"-acetylamino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-3,10,16-trione; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-[4"-(N'-phenylaminocarbonyl)amino-3"-isopropyloxycyclohexy]-1'-methylvinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-[4"-(ethoxycarbonyl)-amino-3"-n-propyloxycyclohexyl]-1'-methylvinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3, 10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-n-propyl-oxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-dimethylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-benzylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-phenyl-2-hydroxyethyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-morpholino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-morpholino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-n-butyloxycyclo-hexyl)-1'-methylvinyl]-23,25-dimethoxy-1,3,19,21,27-tetramethyl-11,18-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-butyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3-methylbutyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(3-methylbutyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2-methylbutyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(2-methylbutyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(N-(2-methyl-3-(4-hydroxy-phenyl)propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-(2-methyl-3-(4-hydroxyphenyl)propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(N-(3-(4-hydroxyphenyl)-propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-(3-(4-hydroxyphenyl)propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 3 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-3-phenylpropenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(N-3-phenylpropenyl)-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(L-Trp)amido-3"-methoxycyclohexyl)-1'-methoxyvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-phenyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-phenyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-phenyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-fluorophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-chlorophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-methylphenyl-oxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-methylphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 .9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-methylphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-phenoxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-phenoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-phenoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-1-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(naphth-1-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-1-yloxy)-3"-hydroxycyclohexyl)-1"-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-napth-2-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(napth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6"'-methoxynaphth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(6"'-methoxynaphth-2-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6"'-methoxynaphth-2-yloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-methoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-methoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(3"'-methoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3"'-methoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-hydroxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-hydroxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6"'-hydroxynaphth-2-yloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(6"'-hydroxynaphth-2-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",4'"-dichlorophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo]22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(phenanthr-9-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",4'"-methylenedioxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2'",3'"-dihydrobenzofuran-5-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(1'",4'"-benzodioxane-6-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,2,14-trihydroxy-12-[2'-(4"-(naphth-2-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-3,10,16-trione; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-allyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-butynyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-methoxy-4"-phenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-allyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-allyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-hydroxy-4"-isopropyloxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-sec-butenyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-sec-butenyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trans-2-butenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo]22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-trans-2-butenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetrane; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-hydroxy-4"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,29,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-hydroxy-4"-(2-methylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-(2-methylpropenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cinnamyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-cinnamyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-sec-butenyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-sec-butenyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-cinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-methoxy-4"-phenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4'"-methoxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'"-methoxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6'"-hydroxynaphth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4'"-hydroxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4'"-methylthiophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,29,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2'"-methylphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,29,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'"-methylphenyloxy)-3"-methoxycyclohexyl-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",4'"-dimethylphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-allyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-butynyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20fluoro-1-hydroxy-12-[2'-(4"-cinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-methoxy-4"-phenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-allyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-allyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-hydroxy-4"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy 13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(trans-2-butenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-(trans-2-butenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-hydroxy-4"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-hydroxy-4"-(2-methylpropenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-(2-methylpropenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-cinnamyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-sec-phenethyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-12,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-methylcinnamyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4-methyl-2,4-hexadienyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(p-methoxycinnamyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'", 4'"-methylenedioxycinnamyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4,4-dimethyl-2-trans-pentenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,4-dihydroxy-12-[2'-(4"-(3-cyclohexyl-2-trans-propenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-p-fluorocinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-chlorocinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-p-bromocinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-methoxy-4"-p-fluorophenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3",4"-diallyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3",4"-dipropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-benzylamino)-ethoxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetra-one; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-benzylamino)-ethoxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacos-18-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(2-benzyloxyethoxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-benzyloxymethoxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yloxy)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(ethoxycarbomethoxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(p-hydroxycinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(p-hydroxycinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",5'"-difluorocinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(3'",5'"-difluorocinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-phenoxy-3"-aminocyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxyphenoxy)cyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-fluorophenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-carboxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-trifluoromethylphenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3'",4'"-dimethoxyphenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-methylphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-methylphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3'"-hydroxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-N-(2-propenyl) amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(acetylamino-3"-(4'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-allyloxy-3"-aminocyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-cinnamyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"amino-3"-cinnamyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-cinnamyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(3"'-phenylpropyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3"'-phenylpropyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(2'"-benzyloxyethoxy)-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2'"-benzyloxyethoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-N-(2-propenyl)amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(L-phenylalanine)-amido-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(D-phenylalanine)-amido-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-cyclopropanecarboxamido-3"-allyloxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-formamido-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"(4'",5'"-dicarboethoxy-1'",2'",3'"-triazole)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-allyl-oxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trimethylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone iodide; 17-Ethyl-20-fluoro-1,2,14-trihydroxy-12-[2'-(4"-acetylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-trione; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-phenyl aminocarbonyl)amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(ethoxycarbonyl)-amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-sec-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-sec-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(3-methyl-2-butenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3-methyl-2-butenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(2-methyl-propenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2-methylpropenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-methoxycinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-fluorocinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; and 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2-butynyloxy)-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; or a pharmaceutically acceptable salt thereof.

Claim 6

A compound which is selected from the group consisting of: 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-teteeone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3",4"-dihydroxy-cyclohexyl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-dihydroxy-12-[2'-(3",4"-dihydroxy-cyclohexyl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-N-(2-propenyl)-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-N-methylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-methylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-1'"-adamantane-carboxamido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cyclopropanecarboxamid-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-formamido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-(4"-(4'",5'"-dicarboethoxy-1'",2'",3'"-triazole)-3"-methoxycyclohexyl)-1'-methylvinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-methoxy-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-hydroxy-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-amino-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-aminocyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-beta-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-alpha-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-beta-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-alpha-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-methylcarbamate-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylcarbamate-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetamidine-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzamidine-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-formamidine-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(L-phenylalanyl)-amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(L-phenylalanyl)amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2"-(4"-(D-phenylalanyl)-amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(D-phenylalanyl)amido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2"-(4"-(aminoacetyl-amino)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(aminoacetylamino)-3"-methoxycyclohexyl)-4'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-hydroxypropyl-amino)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-hydroxypropylamino)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(1-aza-4-oxabicyclo-[4.4.0]dec-6-yl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(1-aza-4-oxabicyclo[4.4.0]-dec-6-yl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trimethylamino-3"methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone Iodide; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-isopropoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-isopropoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Propyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-isopropoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.31.0 4 ,9 ]octacos-18-ene-2,3,20,26-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-[4"-(N'-t-butoxycarbonyl-D-phenylalanine)amido-3"-n-propyloxycyclohexyl]-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetra-methyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-[4"-(N'-t-butoxycarbonyl-L-phenylalanine)amido-3"-n-propyloxycyclohexyl]-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetra-methyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetoxyacetylamino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(1"'-adamantanecarboxamido)-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cyclopropanecarbox-amido-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2-(4"-formamido-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-[4"',5"'-dicarboeth-oxy-1"',2"',3"'-triazole)-3"-n-propyloxycyclohexyl]-1'-methyl-vinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-ethoxycyclo-hexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-benzylamino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trimethylamino-3"-ethoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone-Iodide; 17-Ethyl-20-fluoro-1,2,14-trihydroxy-12-[2'-(4"-acetylamino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-3,10,16-trione; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-[4"-(N'-phenylaminocarbonyl)amino-3"-isopropyloxycyclohexy]-1'-methylvinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-{2'-[4"-(ethoxycarbonyl)-amino-3"-n-propyloxycyclohexyl]-1'-methylvinyl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3, 10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-n-propyl-oxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-dimethylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-benzylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-n-propyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-phenyl-2-hydroxyethyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-morpholino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-morpholino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-n-butyloxycyclo-hexyl)-1'-methylvinyl]-23,25-dimethoxy-1,3,19,21,27-tetramethyl-11,18-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-butyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3-methylbutyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(3-methylbutyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2-methylbutyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(2-methylbutyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(N-(2-methyl-3-(4-hydroxy-phenyl)propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-(2-methyl-3-(4-hydroxyphenyl)propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(N-(3-(4-hydroxyphenyl)-propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-(3-(4-hydroxyphenyl)propenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 3 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-3-phenylpropenyl)amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(N-3-phenylpropenyl)-amino-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(L-Trp)amido-3"-methoxycyclohexyl)-1'-methoxyvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-phenyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-phenyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-phenyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-fluorophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-chlorophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-methylphenyl-oxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-methylphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 .9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-methylphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-phenoxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-phenoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-phenoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-1-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(naphth-1-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-1-yloxy)-3"-hydroxycyclohexyl)-1"-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-napth-2-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(napth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6"'-methoxynaphth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(6"'-methoxynaphth-2-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6"'-methoxynaphth-2-yloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-methoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-methoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(3"'-methoxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3"'-methoxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(4"'-hydroxyphenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4"'-hydroxyphenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6"'-hydroxynaphth-2-yloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-(6"'-hydroxynaphth-2-yloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",4'"-dichlorophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo]22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(phenanthr-9-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",4'"-methylenedioxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2'",3'"-dihydrobenzofuran-5-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(1'",4'"-benzodioxane-6-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,2,14-trihydroxy-12-[2'-(4"-(naphth-2-yl)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-3,10,16-trione; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-allyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-butynyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-methoxy-4"-phenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-allyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-allyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-hydroxy-4"-isopropyloxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-sec-butenyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-sec-butenyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trans-2-butenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo]22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-trans-2-butenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetrane; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-hydroxy-4"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,29,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-hydroxy-4"-(2-methylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-(2-methylpropenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-cinnamyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-cinnamyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-sec-butenyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-sec-butenyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-cinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-methoxy-4"-phenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4'"-methoxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'"-methoxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(6'"-hydroxynaphth-2-yloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4'"-hydroxyphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4'"-methylthiophenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,29,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2'"-methylphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,29,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'"-methylphenyloxy)-3"-methoxycyclohexyl-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",4'"-dimethylphenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-allyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-butynyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20fluoro-1-hydroxy-12-[2'-(4"-cinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-methoxy-4"-phenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-allyloxy-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-allyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-hydroxy-4"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy 13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-isopropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(trans-2-butenyloxy)-3"-hydroxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-(trans-2-butenyloxy)-4"-hydroxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-hydroxy-4"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-(3-methyl-2-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-hydroxy-4"-(2-methylpropenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-hydroxy-3"-(2-methylpropenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3"-cinnamyloxy-4"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-sec-phenethyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-12,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-methylcinnamyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4-methyl-2,4-hexadienyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(p-methoxycinnamyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'", 4'"-methylenedioxycinnamyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(4,4-dimethyl-2-trans-pentenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,4-dihydroxy-12-[2'-(4"-(3-cyclohexyl-2-trans-propenyloxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-p-fluorocinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-chlorocinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-p-bromocinnamyloxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(3"-methoxy-4"-p-fluorophenylpropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3",4"-diallyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(3",4"-dipropyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]-octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(2-benzylamino)-ethoxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetra-one; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(2-benzylamino)-ethoxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacos-18-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(2-benzyloxyethoxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-benzyloxymethoxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(naphth-2-yloxy)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(ethoxycarbomethoxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(p-hydroxycinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(p-hydroxycinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(3'",5'"-difluorocinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(3'",5'"-difluorocinnamyl)oxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-phenoxycyclohexyl-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-phenoxy-3"-aminocyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxyphenoxy)cyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-fluorophenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-carboxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-trifluoromethylphenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3'",4'"-dimethoxyphenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-methylphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-methylphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3'"-hydroxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-N-(2-propenyl) amino-3"-phenoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-(acetylamino-3"-(4'"-methoxyphenoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-allyloxy-3"-aminocyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-cinnamyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"amino-3"-cinnamyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-cinnamyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(3"'-phenylpropyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3"'-phenylpropyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(2'"-benzyloxyethoxy)-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2'"-benzyloxyethoxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Allyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-hydroxycinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-acetylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-acetylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-N-(2-propenyl)amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(L-phenylalanine)-amido-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(D-phenylalanine)-amido-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-cyclopropanecarboxamido-3"-allyloxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-formamido-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"(4'",5'"-dicarboethoxy-1'",2'",3'"-triazole)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-benzylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-dimethylamino-3"-allyl-oxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-trimethylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone iodide; 17-Ethyl-20-fluoro-1,2,14-trihydroxy-12-[2'-(4"-acetylamino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-trione; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(N-phenyl aminocarbonyl)amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-(ethoxycarbonyl)-amino-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-sec-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-sec-butenyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(3-methyl-2-butenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(3-methyl-2-butenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1,14-dihydroxy-12-[2'-(4"-amino-3"-(2-methyl-propenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2-methylpropenyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-methoxycinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(4'"-fluorocinnamyloxy)cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; and 17-Ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-amino-3"-(2-butynyloxy)-cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4 ,9 ]octacos-18-ene-2,3,10,16-tetraone; or a pharmaceutically acceptable salt thereof.

Claim 7

A compound of claim 4 which is: ##STR206##

Claim 8

A compound of claim 4 which is: ##STR207##

Claim 9

A compound of claim 4 which is: ##STR208##

Claim 10

A compound of claim 4 which is: ##STR209##

Claim 11

A compound of claim 4 which is: ##STR210##

Claim 12

A compound of claim 4 which is: ##STR211##

Claim 13

A pharmaceutical composition for the treatment of immunoregulatory disorders or diseases comprising a pharmaceutical carrier and a therapeutically effective amount of the compound of claim 1.

Claim 14

A pharmaceutical composition for the treatment of resistance to transplantation comprising a pharmaceutical carrier and a therapeutically effective amount of the compound of claim 1.

Claim 15

A pharmaceutical composition for the topical treatment of inflammatory and hyperproliferative skin diseases and or cutaneous manifestations of immunologically-mediated illnesses comprising a pharmaceutical carrier and a therapeutically effective amount of the compound of claim 1.

Claim 16

A pharmaceutical composition for the treatment of reversible obstructive airways disease comprising a pharmaceutical carrier and a therapeutically effective amount of the compound of claim 1.

Claim 17

A pharmaceutical composition for the treatment of male pattern alopecia or alopecia senilis a comprising a pharmaceutical carrier and a therapeutically effective amount of the compound of claim 1.

Claim 18

A method for the treatment of immunoregulatory disorders or diseases comprising the administration to a mammalian species in need of such treatment an effective amount of the compound of claim 1.

Claim 19

A method for the treatment of resistance to transplantation comprising the administration to a mammalian species in need of such treatment an effective amount of the compound of claim 1.

Claim 20

A method for the topical treatment of inflammatory and hyperproliferative skin diseases and or cutaneous manifestations of immunologically-mediated illnesses comprising the administration to a mammalian species in need of such treatment of an effective amount of the compound of claim 1.

Claim 21

A method for the treatment of reversible obstructive airways disease comprising the administration to a mammalian species in need of such treatment of an effective amount of the compound of claim 1.

Claim 22

A method for revitalizing hair comprising the administration to a mammalian species in need of such treatment of an effective amount of the compound of claim 1.

Claim 23

A method for the treatment of male pattern alopecia or alopecia senilis comprising the administration to a mammalian species in need of such treatment of an effective amount of the compound of claim 1.