EP0423714A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Hair revitalizing agent
Assignee: Astellas Pharma Inc
•
Filing: 1990-10-16
•
Granted: —
•
Expires: 2010-10-16
Abstract
Abstract A hair revitalizing agent including a compound represented by the formula shown below or a pharmaceutically acceptable salt thereof: <CHEM> (wherein R<1> to R<1><0>, R<1><4> to R<2><3>, X, Y, and n are the same as defined in the present specification).
Inventors
- 👤 Toshiyasu Honbo
- 👤 Takehisa Hata
- 👤 Akihiro Ishino
- 👤 Yoshiharu Tsuji
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 02:19
CPC Classifications
A; A61; A61Q; A61Q7/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61P; A61P17/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
382 words
A hair revitalizing agent containing a compound represented by the formula shown below, or a pharmaceutically acceptable salt thereof: (wherein each adjoining pair of R¹ and R², R³ and R⁴, R⁵ and R⁶ independently, a) represents two adjoining hydrogen atoms, or b) forms another bond with a carbon atom to which it is bonded, and in addition thereto, R² may be an alkyl group; R⁷ represents a hydrogen atom, a hydroxy group, a protected hydroxy group, or an alkyloxy group, or represents an oxo group together with R¹; R⁸ and R⁹ independently represent a hydrogen atom, or a hydroxy group; R¹⁰ represents a hydrogen atom, an alkyl group, an alkyl group substituted with 1 or more hydroxy groups, an alkenyl group, an alkenyl group substituted with 1 or more hydroxy groups, or an alkyl group substituted with an oxo group; X represents an oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom) or a group represented by -CH₂O-; Y represents an oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom), or a group represented by the formula N-NR¹¹R¹² or N-OR¹³; R¹¹ and R¹² independently represent a hydrogen atom, an alkyl group, an aryl group or a tosyl group; R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²² and R²³ independently represent a hydrogen atom or an alkyl group; R²⁰ and R²¹ independently represent an oxo group, or may be each independently (R 20 a , hydrogen atom) and (R 21 a , hydrogen atom); R 20 a and R21 a independently represent a hydroxy group, an alkyloxy group or a group represented by the formula OCH₂OCH₂CH₂OCH₃ , or R 21 a represents a protected hydroxy group, and further, R 20 a and R 21 a taken together form an oxygen atom in an epoxy ring; n represents 1, 2 or 3, and in addition to the above meanings, Y, R¹⁰, and R²³ together with the carbon atoms to which they are bonded may represent a heterocyclic group containing nitrogen atom, sulfur atom or oxygen atom comprising a saturated or unsaturated 5- or 6-membered ring, and the heterocyclic group may be substituted with 1 or more group selected from alkyl groups, hydroxy group, alkyl groups substituted with 1 or more hydroxy group, alkyloxy groups, benzyl group and the group represented by -CH₂Se(C₆H₅).
Claim 2
Dependent Claim
382 words
A hair revitalizing agent containing a compound represented by the formula shown below, or a pharmaceutically acceptable salt thereof: (wherein each adjoining pair of R¹ and R², R³ and R⁴, R⁵ and R⁶ independently, a) represents two adjoining hydrogen atoms, or b) forms another bond with a carbon atom to which it is bonded, and in addition thereto, R² may be an alkyl group; R⁷ represents a hydrogen atom, a hydroxy group, a protected hydroxy group, or an alkyloxy group, or represents an oxo group together with R¹; R⁸ and R⁹ independently represent a hydrogen atom, or a hydroxy group; R¹⁰ represents a hydrogen atom, an alkyl group, an alkyl group substituted with 1 or more hydroxy groups, an alkenyl group, an alkenyl group substituted with 1 or more hydroxy groups, or an alkyl group substituted with an oxo group; X represents an oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom) or a group represented by -CH₂O-; Y represents an oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom), or a group represented by the formula N-NR¹¹R¹² or N-OR¹³; R¹¹ and R¹² independently represent a hydrogen atom, an alkyl group, an aryl group or a tosyl group; R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²² and R²³ independently represent a hydrogen atom or an alkyl group; R²⁰ and R²¹ independently represent an oxo group, or may be each independently (R 20 a , hydrogen atom) and (R 21 a , hydrogen atom); R 20 a and R21 a independently represent a hydroxy group, an alkyloxy group or a group represented by the formula OCH₂OCH₂CH₂OCH₃ , or R 21 a represents a protected hydroxy group, and further, R 20 a and R 21 a taken together form an oxygen atom in an epoxy ring; n represents 1, 2 or 3, and in addition to the above meanings, Y, R¹⁰, and R²³ together with the carbon atoms to which they are bonded may represent a heterocyclic group containing nitrogen atom, sulfur atom or oxygen atom comprising a saturated or unsaturated 5- or 6-membered ring, and the heterocyclic group may be substituted with 1 or more group selected from alkyl groups, hydroxy group, alkyl groups substituted with 1 or more hydroxy group, alkyloxy groups, benzyl group and the group represented by -CH₂Se(C₆H₅).
Claim 3
Dependent Claim
15 words
A use of a compound (I) defined in claim 1 as a hair revitalizing agent.
Claim 4
Dependent Claim
16 words
A use of a compound (I) defined in claims 1 for manufacturing a hair revitalizing agent.
Claim 5
Dependent Claim
20 words
A hair revitalizing agent used in claims 1, 2 and 3 is for treating male pattern alopecia or alopecia senilis.
Claim 6
Dependent Claim
22 words
A method for revitalizing hair which comprises administering an effective amount of a compound (I) defined in claim 1 to a subject.
Claim 7
Dependent Claim
27 words
A method for treating male pattern alopecia or alopecia senilis which comprises administering an effective amount of a compound (I) defined in claim 1 to a subject.
Claim 8
Dependent Claim
15 words
A compound (I) used in claim 1, 2, 3, 4, 5 or 6 is FK-506.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.