EP0315978A2
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EP
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New use of 11,28-dioxa-4-azatricyclo [22.3.1.0 4,9]octacos-18-ene derivatives and pharmaceutical compositions containing them
Assignee: Astellas Pharma Inc
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Filing: 1988-11-09
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Granted: —
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Expires: 2008-11-09
Abstract
Abstract The compounds of formula I, have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.
Inventors
- 👤 Maximilian Grassberger
- 👤 Josef Gottfried Meingassner
- 👤 Anton Stütz
- 👤 Peter Stütz
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 22:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/4353; A61K31/436; A61K31/335; A61K31/35; A61K31/40; A61K31/407; A61K31/445; A61K31/70; A61P; A61P17/00; A61P29/00; A61P37/00; A61P37/08
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
106 words
Use of a compound of formula I, wherein R¹ is optionally protected hydroxy, R² is hydrogen or optionally protected hydroxy, R³ is methyl, ethyl, propyl or allyl, n is 1 or 2 and the symbol of a line and dotted line is a single bond or a double bond, in free form or in pharmaceutically acceptable salt form, in the topical treatment of inflammatory and hyperproliferative skin diseases and of cutaneous manifestations of immunologically-mediated illnesses, such as: psoriasis, atopical dermatitis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinophilias, Lupus erythematosus or Alopecia areata.
Claim 2
Dependent Claim
106 words
Use of a compound of formula I, wherein R¹ is optionally protected hydroxy, R² is hydrogen or optionally protected hydroxy, R³ is methyl, ethyl, propyl or allyl, n is 1 or 2 and the symbol of a line and dotted line is a single bond or a double bond, in free form or in pharmaceutically acceptable salt form, in the topical treatment of inflammatory and hyperproliferative skin diseases and of cutaneous manifestations of immunologically-mediated illnesses, such as: psoriasis, atopical dermatitis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinophilias, Lupus erythematosus or Alopecia areata.
Claim 3
Dependent Claim
30 words
Use according to claim 1 of a compound of formula I as defined in claim 1, in free form or in pharaceutically salt form, in the topical treatment of psoriasis.
Claim 4
Dependent Claim
48 words
Use according to claim 1 or claim 2 of a compound of formula I wherein R¹ and R² are hydroxy, R³ is allyl, n is 2 and the symbol of a line and dotted line is a single bond, in free form or in pharmaceutically acceptable salt form.
Claim 5
Dependent Claim
22 words
Use according to claim 1 or 2 of the compound of formula Ia in free form or in pharaceutically acceptable salt form.
Claim 6
Dependent Claim
71 words
A pharmaceutical composition for use of a compound of formula I as defined in claim 1, in free form or in pharmaceutically acceptable salt form in the topical treatment of inflammatory or hyperproliferative skin diseases or of cutaneous manifestations of immunologically-mediated illnesses, psoriasis, atopical dermatitis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinophilias, Lupus erythematosus or Alopecia areata.
Claim 7
Dependent Claim
10 words
A composition according to claim 5 for use in psoriasis.
Claim 8
Dependent Claim
15 words
A composition according to claim 5 or 6 comprising a 1-3% concentration of active substance.
Claim 9
Dependent Claim
15 words
A composition according to claim 5 or 6 which is a lotion, gel or creme.
Claim 10
Dependent Claim
35 words
Use of a compound of formula I as defined in claim 1 for the preparation of a medicament for the topical treatment of inflammatory or hyperproliferative skin diseases or of cutaneous manifestations of immunologically-induced illnesses.
Claim 11
Dependent Claim
45 words
Use according to claim 9 for the preparation of a medicament for the topical treatment of psoriasis, atopical dermatitis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinophilias, Lupus erythematosus or Alopecia areata.
References Cited (Backward Citations)
No citation records indexed.
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