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US5140043A
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Stable ascorbic acid compositions
Assignee: Duke University
•
Filing: 1989-04-17
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Granted: 1992-08-18
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Expires: 2009-04-17
Abstract
Abstract Stable topical aqueous compositions are provided containing a concentration of L-ascorbic acid above about 1% (W/V) and maintaining a pH below about 3.5.
Inventors
- 👤 Douglas Darr
- 👤 Sheldon R. Pinnell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:13
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375; A61K47/06; A61K47/08; A61K47/10; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/34; A61K8/345; A61K8/39; A61K8/67; A61K8/676; A61K8/72; A61K8/73; A61K8/731; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P17/00; A61P17/16; A61Q; A61Q19/00; A61K2800/00; A61K2800/40; A61K2800/51; A61Q17/00; A61Q17/04; A61Q19/004
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
47 words
A topical composition consisting essentially of from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 2
Dependent Claim
47 words
A topical composition consisting essentially of from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein the carrier comprises an alkylene glycol.
Claim 4
Dependent Claim
12 words
The composition of claim 2 wherein the alkylene glycol is propylene glycol.
Claim 5
Dependent Claim
17 words
The composition of claim 1 wherein the carrier is a combination of an alkylene glycol and hydroxyalkylcellulose.
Claim 6
Dependent Claim
12 words
The composition of claim 4 wherein the alkylene glycol is propylene glycol.
Claim 7
Dependent Claim
19 words
The composition of claim 1 wherein the ratio of water to carrier is from about 2:1 to about 10:1.
Claim 8
Dependent Claim
19 words
The composition of claim 2 wherein the ratio of water to carrier is from about 2:1 to about 10:1.
Claim 9
Dependent Claim
19 words
The composition of claim 3 wherein the ratio of water to carrier is from about 2:1 to about 10:1.
Claim 10
Dependent Claim
50 words
A topical composition consisting essentially of between 3 and 20% ascorbic acid (w/v) and 80% to 97% water and a carrier suitable for topical application wherein the ratio of water to carrier is at lest about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 11
Dependent Claim
50 words
A topical composition consisting essentially of between 3 and 20% ascorbic acid (w/v) and 80% to 97% water and a carrier suitable for topical application wherein the ratio of water to carrier is at lest about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 12
Dependent Claim
17 words
The composition of claim 9 wherein the carrier is a combination of an alkylene glycol and hydroxyalkylcellulose.
Claim 13
Dependent Claim
19 words
The composition of claim 10 wherein the ratio of alkylene glycol to hydroxyalkylcellulose is from about 30:1 to 5:1.
Claim 14
Dependent Claim
17 words
The composition of claim 11 wherien the alkylene glycol is propylene glycol and the hydroxylalkycellulose is hydroxypropylcellulose.
Claim 15
Dependent Claim
21 words
The composition of claim 1 or 9 wherein the composition is a dermatogical composition and the carrier is a dermatological carrier.
Claim 16
Dependent Claim
16 words
The composition of claim 1 or 9 wherein the pH is no more than about 2.5.
Claim 17
Dependent Claim
21 words
The composition of claim 1 wherein the water is selected from the group consisting of distilled, deionized and distilled deionized water.
Claim 18
Dependent Claim
14 words
The composition of claim 15 wherien the pH is no more than about 2.5.
Claim 19
Dependent Claim
51 words
A topical composition consisting essentially of about 5 to 10% ascorbic acid (w/v) and about 90 to 95% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 20
Dependent Claim
51 words
A topical composition consisting essentially of about 5 to 10% ascorbic acid (w/v) and about 90 to 95% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 21
Dependent Claim
17 words
The composition of claim 17 wherein the carrier is a combination of an alkylene glycol and hydroxyalkycellulose.
Claim 22
Dependent Claim
19 words
The composition of claim 18 wherein the ratio of alkylene glycol to hydroxyalkylcellulose is from about 30:1 to 5:1.
Claim 23
Dependent Claim
17 words
The composition of claim 19 wherein the alkylene glycol is propylene glycol and the hydroxyalkylcellulose is hydroxypropycellulose.
Claim 24
Dependent Claim
15 words
The composition of claim 17 wherein the water is distilled, deionized, or distilled deionized water.
Claim 25
Dependent Claim
45 words
A topical composition containing from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 26
Dependent Claim
45 words
A topical composition containing from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 27
Dependent Claim
13 words
The composition of claim 22 wherein the cosmetic carrier comprises an alkylene glycol.
Claim 28
Dependent Claim
14 words
The composition of claim 23 wherein the pH is no more than about 2.5.
Claim 29
Dependent Claim
21 words
The composition of claim 22 wherein the water is selected from the group consisting of distilled, deionized and distilled deionized water.
Claim 30
Dependent Claim
14 words
The composition of claim 25 wherein the Ph is no more than about 2.5.
Claim 31
Dependent Claim
19 words
The composition of claim 22 wherein the composition is a dermatoligical composition and the carrier is a dermatological carrier.
Claim 32
Dependent Claim
19 words
The composition of claim 23 wherein the ratio of water to carrier is from about 2:1 to about 10:1.
Claim 33
Dependent Claim
47 words
A topical composition containing between 3 20% ascorbic acid (w/v) and 80% to 97% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 34
Dependent Claim
47 words
A topical composition containing between 3 20% ascorbic acid (w/v) and 80% to 97% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 35
Dependent Claim
17 words
The composition of claim 29 wherein the carrier is a combination of an alkylene glycol and hydroxyalkylcellulose.
Claim 36
Dependent Claim
49 words
A topical composition containing about 5 to 10% ascorbic acid (w/v) and about 90 to 95% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 37
Dependent Claim
49 words
A topical composition containing about 5 to 10% ascorbic acid (w/v) and about 90 to 95% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 38
Independent Claim
63 words
A method of retarding damage to skin by ultraviolet light which comprises applying a topical composition on the skin consisting essentially of at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1: 1 and wherein composition has a pH of mo more than about 3.5.
Claim 39
Independent Claim
63 words
A method of retarding damage to skin by ultraviolet light which comprises applying a topical composition on the skin consisting essentially of at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1: 1 and wherein composition has a pH of mo more than about 3.5.
Claim 40
Dependent Claim
28 words
The method of claim 32 wherein the topical composition consists essentially of between about 3 and 20% ascorbic acid (w/v) and 80 to 97% water and carrier (v/v).
Claim 41
Dependent Claim
14 words
The method of claim 33 wherein the carrier comprises an alkylene glycol and hydroxyalkylcellulose.
Claim 42
Dependent Claim
17 words
The method of claim 34 wherein the alkylene glycol is propylene glycol and the hydroxyalkylcellulose is hydroxypropylcellulose.
Claim 43
Dependent Claim
20 words
The method of claim 34 wherein the ratio of water to carrier is from about 2: 1 to about 10:1.
Claim 44
Dependent Claim
19 words
The method of claim 35 wherein the ratio of water to carrier is from about 2:1 to about 10:1.
Claim 45
Independent Claim
65 words
A method of preventing damage to skin by ultraviolet light comprising the step of applying a topical composition to the skin consisting essentially of from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 46
Independent Claim
65 words
A method of preventing damage to skin by ultraviolet light comprising the step of applying a topical composition to the skin consisting essentially of from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 47
Dependent Claim
57 words
The method of claim 38 wherein the topically applied composition consists essentially of between 3 and 20% ascorbic acid (w/v) and 80% to 97% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 48
Independent Claim
65 words
A method of treating damage to skin by ultraviolet light comprising the step of applying a topical composition to the skin consisting essentially of from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 49
Independent Claim
65 words
A method of treating damage to skin by ultraviolet light comprising the step of applying a topical composition to the skin consisting essentially of from at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 50
Dependent Claim
57 words
The method of claim 40 wherein the topically applied composition consists essentially of between 3 and 20% ascorbic acid (w/v) and 80% to 97% water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein the composition has a pH of no more than about 3.5.
Claim 51
Independent Claim
60 words
A method of retarding damage to skin by ultraviolet light which comprises applying a topical composition to the skin containing at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein composition has a pH of no more than about 3.5.
Claim 52
Independent Claim
60 words
A method of retarding damage to skin by ultraviolet light which comprises applying a topical composition to the skin containing at least about 1% ascorbic acid (w/v) in water and a carrier suitable for topical application wherein the ratio of water to carrier is at least about 1:1 and wherein composition has a pH of no more than about 3.5.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-18 | 1996-02-17 | 1996-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-18 | 2000-02-17 | 2000-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-18 | 2004-02-17 | 2004-08-18 | $7700.00 | Window Closed / Lapsed |